Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice
Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crud...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Wolters Kluwer Medknow Publications
2018
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Online Access: | https://doi.org/10.4103/1995-7645.244517 https://doaj.org/article/f26e8d4e6417413b9ac1f05f7947a2f7 |
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ftdoajarticles:oai:doaj.org/article:f26e8d4e6417413b9ac1f05f7947a2f7 2023-05-15T15:08:59+02:00 Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.244517 https://doaj.org/article/f26e8d4e6417413b9ac1f05f7947a2f7 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=10;spage=570;epage=575;aulast=Alemu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.244517 https://doaj.org/article/f26e8d4e6417413b9ac1f05f7947a2f7 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 10, Pp 570-575 (2018) schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.244517 2022-12-31T12:23:53Z Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 10 570 |
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Open Polar |
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op_collection_id |
ftdoajarticles |
language |
English |
topic |
schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia Arctic medicine. Tropical medicine RC955-962 Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
topic_facet |
schistosoma mansoni echinops kebericho hagenia abyssinica crude extract antischistosomal activity ethiopia Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity. |
format |
Article in Journal/Newspaper |
author |
Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman |
author_facet |
Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman |
author_sort |
Yonas Alemu |
title |
Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
title_short |
Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
title_full |
Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
title_fullStr |
Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
title_full_unstemmed |
Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice |
title_sort |
anti-schistosomal activities of echinops kebericho mesfin root and hagenia abyssinica (bruce) j.f gmel flower part crude extracts in swiss albino mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.244517 https://doaj.org/article/f26e8d4e6417413b9ac1f05f7947a2f7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 10, Pp 570-575 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=10;spage=570;epage=575;aulast=Alemu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.244517 https://doaj.org/article/f26e8d4e6417413b9ac1f05f7947a2f7 |
op_doi |
https://doi.org/10.4103/1995-7645.244517 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
10 |
container_start_page |
570 |
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1766340245166489600 |