Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community.
INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identi...
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ftdoajarticles:oai:doaj.org/article:f1af8f18aa4a4378b53716915a4de7b8 2023-05-15T15:16:05+02:00 Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. Benoit de Thoisy Hervé Bourhy Marguerite Delaval Dominique Pontier Laurent Dacheux Edith Darcissac Damien Donato Amandine Guidez Florence Larrous Rachel Lavenir Arielle Salmier Vincent Lacoste Anne Lavergne 2016-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004378 https://doaj.org/article/f1af8f18aa4a4378b53716915a4de7b8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4726525?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004378 https://doaj.org/article/f1af8f18aa4a4378b53716915a4de7b8 PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004378 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004378 2022-12-31T12:36:22Z INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecological drivers of RABV circulation in neotropical bat communities, we conducted a molecular and serological survey on almost 1,000 bats from 30 species, and a 4-year longitudinal survey in two colonies of vampire bats in French Guiana. RABV was molecularly detected in a common vampire and in a frugivorous bat. The sequences corresponded to haematophagous bat-related strains and were close to viruses circulating in the Brazilian Amazon region. Species' seroprevalence ranged from 0 to 20%, and the risk of seropositivity was higher in bats with a haematophagous diet, living in monospecific colonies and in dense forests. The longitudinal survey showed substantial temporal fluctuations, with individual waves of seroconversions and waning immunity. The high prevalences observed in bat communities, in most habitats and in species that do not share the same microhabitats and bioecological patterns, the temporal variations, and a rather short period of detectable antibodies as observed in recaptured vampires suggest (i) frequent exposure of animals, (ii) an ability of the infected host to control and eliminate the virus, (iii) more relaxed modes of exposure between bats than the commonly assumed infection via direct contact with saliva of infected animals, all of which should be further investigated. CONCLUSIONS / SIGNIFICANCE:We hypothesize that RABV circulation in French Guiana is mainly maintained in the pristine forest habitats that may provide sufficient food resources to allow vampire bats, the main prevalent species, to survive and RABV to be propagated. However, on the forest edge and in disturbed areas, human activities may induce more insidious effects such as defaunation. One of the ecological ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 1 e0004378 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Benoit de Thoisy Hervé Bourhy Marguerite Delaval Dominique Pontier Laurent Dacheux Edith Darcissac Damien Donato Amandine Guidez Florence Larrous Rachel Lavenir Arielle Salmier Vincent Lacoste Anne Lavergne Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:In addition to the commonly accepted importance of the vampire bat in the maintenance and transmission of the rabies virus (RABV) in South America, RABV infection of other species is widely evidenced, challenging their role in the viral cycle. METHODOLOGY / PRINCIPLES FINDINGS:To identify the bioecological drivers of RABV circulation in neotropical bat communities, we conducted a molecular and serological survey on almost 1,000 bats from 30 species, and a 4-year longitudinal survey in two colonies of vampire bats in French Guiana. RABV was molecularly detected in a common vampire and in a frugivorous bat. The sequences corresponded to haematophagous bat-related strains and were close to viruses circulating in the Brazilian Amazon region. Species' seroprevalence ranged from 0 to 20%, and the risk of seropositivity was higher in bats with a haematophagous diet, living in monospecific colonies and in dense forests. The longitudinal survey showed substantial temporal fluctuations, with individual waves of seroconversions and waning immunity. The high prevalences observed in bat communities, in most habitats and in species that do not share the same microhabitats and bioecological patterns, the temporal variations, and a rather short period of detectable antibodies as observed in recaptured vampires suggest (i) frequent exposure of animals, (ii) an ability of the infected host to control and eliminate the virus, (iii) more relaxed modes of exposure between bats than the commonly assumed infection via direct contact with saliva of infected animals, all of which should be further investigated. CONCLUSIONS / SIGNIFICANCE:We hypothesize that RABV circulation in French Guiana is mainly maintained in the pristine forest habitats that may provide sufficient food resources to allow vampire bats, the main prevalent species, to survive and RABV to be propagated. However, on the forest edge and in disturbed areas, human activities may induce more insidious effects such as defaunation. One of the ecological ... |
format |
Article in Journal/Newspaper |
author |
Benoit de Thoisy Hervé Bourhy Marguerite Delaval Dominique Pontier Laurent Dacheux Edith Darcissac Damien Donato Amandine Guidez Florence Larrous Rachel Lavenir Arielle Salmier Vincent Lacoste Anne Lavergne |
author_facet |
Benoit de Thoisy Hervé Bourhy Marguerite Delaval Dominique Pontier Laurent Dacheux Edith Darcissac Damien Donato Amandine Guidez Florence Larrous Rachel Lavenir Arielle Salmier Vincent Lacoste Anne Lavergne |
author_sort |
Benoit de Thoisy |
title |
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
title_short |
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
title_full |
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
title_fullStr |
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
title_full_unstemmed |
Bioecological Drivers of Rabies Virus Circulation in a Neotropical Bat Community. |
title_sort |
bioecological drivers of rabies virus circulation in a neotropical bat community. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004378 https://doaj.org/article/f1af8f18aa4a4378b53716915a4de7b8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004378 (2016) |
op_relation |
http://europepmc.org/articles/PMC4726525?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004378 https://doaj.org/article/f1af8f18aa4a4378b53716915a4de7b8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004378 |
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PLOS Neglected Tropical Diseases |
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10 |
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1 |
container_start_page |
e0004378 |
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