Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners
BACKGROUND: Cytokines secrete all cells when there is a threat of damage to it. Leptin, having all the properties of a cytokine, produces fat cells. It was of interest to identify the ratio of leptin concentrations and cytokines activating preventive inflammatory reactions in the blood of practicall...
Published in: | Obesity and metabolism |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English Russian |
Published: |
Endocrinology Research Centre
2024
|
Subjects: | |
Online Access: | https://doi.org/10.14341/omet12952 https://doaj.org/article/f16fec577b2a4cab8f46f1fcdccea165 |
id |
ftdoajarticles:oai:doaj.org/article:f16fec577b2a4cab8f46f1fcdccea165 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f16fec577b2a4cab8f46f1fcdccea165 2024-09-15T17:54:48+00:00 Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners A. V. Samodova L. K. Dobrodeeva K. O. Pashinskaya N. P. Geshavets 2024-08-01T00:00:00Z https://doi.org/10.14341/omet12952 https://doaj.org/article/f16fec577b2a4cab8f46f1fcdccea165 EN RU eng rus Endocrinology Research Centre https://www.omet-endojournals.ru/jour/article/view/12952 https://doaj.org/toc/2071-8713 https://doaj.org/toc/2306-5524 2071-8713 2306-5524 doi:10.14341/omet12952 https://doaj.org/article/f16fec577b2a4cab8f46f1fcdccea165 Ожирение и метаболизм, Vol 21, Iss 2, Pp 107-115 (2024) leptin pro-inflammatory anti-inflammatory cytokines fat metabolism lipolysis transport forms of blood lipids hyperlipoproteidemia Physiology QP1-981 Biochemistry QD415-436 article 2024 ftdoajarticles https://doi.org/10.14341/omet12952 2024-08-26T15:21:15Z BACKGROUND: Cytokines secrete all cells when there is a threat of damage to it. Leptin, having all the properties of a cytokine, produces fat cells. It was of interest to identify the ratio of leptin concentrations and cytokines activating preventive inflammatory reactions in the blood of practically healthy Northerners with hyperlipoproteidemia.AIM: To identify the ratio of concentrations of leptin and IL-1ß, TNF-α, IL-6 and IL-10 in the blood of practically healthy Northerners with hyperlipoproteidemia.MATERIAL AND METHODS: A survey of 286 practically healthy people aged 35-55 years living in the Arkhangelsk region was conducted. The body mass index in persons of the first group (n=211) was in the range of 19.5-26.8 kg/m2 and corresponded to the norm; and 75 people of the second group (body mass index 31-40 kg/m2). Concentrations of leptin, interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined in the blood by enzyme immunoassay on an automatic Evolis enzyme immunoassay analyzer from Bio-Rad (Germanytotal cholesterol (OH), apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoV), high-density lipoproteins (HDL), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), oxidized low-density lipoproteins (LDL), triglycerides (TG), phospholipids (FL) on the biochemical analyzer «Stat fax 1904 Plus» of the company «Awareness Technology, Inc.» USA.RESULTS: Fasting hyperlipoproteidemia in practically healthy people is associated with an increase in the concentration of leptin in the blood within the physiological content. The closest relationship between an increase in leptin levels and concentrations of proinflammatory cytokines IL-1ß, TNF-α and IL-6 was established (r=0.68, 0.74 and 0.83, respectively; p<0.001). The severity of the reaction of proinflammatory cytokines is regulated by a parallel increase in the secretion of anti-inflammatory IL-10 (r=0.62; p<0.001).CONCLUSION: It should be recognized that the stimulation of ... Article in Journal/Newspaper Arkhangelsk Directory of Open Access Journals: DOAJ Articles Obesity and metabolism 21 2 107 115 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Russian |
topic |
leptin pro-inflammatory anti-inflammatory cytokines fat metabolism lipolysis transport forms of blood lipids hyperlipoproteidemia Physiology QP1-981 Biochemistry QD415-436 |
spellingShingle |
leptin pro-inflammatory anti-inflammatory cytokines fat metabolism lipolysis transport forms of blood lipids hyperlipoproteidemia Physiology QP1-981 Biochemistry QD415-436 A. V. Samodova L. K. Dobrodeeva K. O. Pashinskaya N. P. Geshavets Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
topic_facet |
leptin pro-inflammatory anti-inflammatory cytokines fat metabolism lipolysis transport forms of blood lipids hyperlipoproteidemia Physiology QP1-981 Biochemistry QD415-436 |
description |
BACKGROUND: Cytokines secrete all cells when there is a threat of damage to it. Leptin, having all the properties of a cytokine, produces fat cells. It was of interest to identify the ratio of leptin concentrations and cytokines activating preventive inflammatory reactions in the blood of practically healthy Northerners with hyperlipoproteidemia.AIM: To identify the ratio of concentrations of leptin and IL-1ß, TNF-α, IL-6 and IL-10 in the blood of practically healthy Northerners with hyperlipoproteidemia.MATERIAL AND METHODS: A survey of 286 practically healthy people aged 35-55 years living in the Arkhangelsk region was conducted. The body mass index in persons of the first group (n=211) was in the range of 19.5-26.8 kg/m2 and corresponded to the norm; and 75 people of the second group (body mass index 31-40 kg/m2). Concentrations of leptin, interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined in the blood by enzyme immunoassay on an automatic Evolis enzyme immunoassay analyzer from Bio-Rad (Germanytotal cholesterol (OH), apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoV), high-density lipoproteins (HDL), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), oxidized low-density lipoproteins (LDL), triglycerides (TG), phospholipids (FL) on the biochemical analyzer «Stat fax 1904 Plus» of the company «Awareness Technology, Inc.» USA.RESULTS: Fasting hyperlipoproteidemia in practically healthy people is associated with an increase in the concentration of leptin in the blood within the physiological content. The closest relationship between an increase in leptin levels and concentrations of proinflammatory cytokines IL-1ß, TNF-α and IL-6 was established (r=0.68, 0.74 and 0.83, respectively; p<0.001). The severity of the reaction of proinflammatory cytokines is regulated by a parallel increase in the secretion of anti-inflammatory IL-10 (r=0.62; p<0.001).CONCLUSION: It should be recognized that the stimulation of ... |
format |
Article in Journal/Newspaper |
author |
A. V. Samodova L. K. Dobrodeeva K. O. Pashinskaya N. P. Geshavets |
author_facet |
A. V. Samodova L. K. Dobrodeeva K. O. Pashinskaya N. P. Geshavets |
author_sort |
A. V. Samodova |
title |
Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
title_short |
Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
title_full |
Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
title_fullStr |
Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
title_full_unstemmed |
Relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
title_sort |
relationship of leptin concentrations as part of cytokine response to hyperlipoproteidemia in practically healthy northerners |
publisher |
Endocrinology Research Centre |
publishDate |
2024 |
url |
https://doi.org/10.14341/omet12952 https://doaj.org/article/f16fec577b2a4cab8f46f1fcdccea165 |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_source |
Ожирение и метаболизм, Vol 21, Iss 2, Pp 107-115 (2024) |
op_relation |
https://www.omet-endojournals.ru/jour/article/view/12952 https://doaj.org/toc/2071-8713 https://doaj.org/toc/2306-5524 2071-8713 2306-5524 doi:10.14341/omet12952 https://doaj.org/article/f16fec577b2a4cab8f46f1fcdccea165 |
op_doi |
https://doi.org/10.14341/omet12952 |
container_title |
Obesity and metabolism |
container_volume |
21 |
container_issue |
2 |
container_start_page |
107 |
op_container_end_page |
115 |
_version_ |
1810431096840519680 |