In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas )
Pacific oyster ( Crassostrea gigas ), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of t...
Published in: | Molecules |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2023
|
Subjects: | |
Online Access: | https://doi.org/10.3390/molecules28020651 https://doaj.org/article/f16bd7613ff1436aaf858b03ae6c1576 |
id |
ftdoajarticles:oai:doaj.org/article:f16bd7613ff1436aaf858b03ae6c1576 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f16bd7613ff1436aaf858b03ae6c1576 2023-05-15T15:57:34+02:00 In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) Leyi Zhou Rufa L. Mendez Jung Yeon Kwon 2023-01-01T00:00:00Z https://doi.org/10.3390/molecules28020651 https://doaj.org/article/f16bd7613ff1436aaf858b03ae6c1576 EN eng MDPI AG https://www.mdpi.com/1420-3049/28/2/651 https://doaj.org/toc/1420-3049 doi:10.3390/molecules28020651 1420-3049 https://doaj.org/article/f16bd7613ff1436aaf858b03ae6c1576 Molecules, Vol 28, Iss 651, p 651 (2023) in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Organic chemistry QD241-441 article 2023 ftdoajarticles https://doi.org/10.3390/molecules28020651 2023-01-22T01:26:43Z Pacific oyster ( Crassostrea gigas ), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discovery pipeline. To overcome this constraint, in silico-based prospecting is employed to accelerate BAP discovery. Major oyster proteins were digested virtually under a simulated gastrointestinal condition to generate virtual peptide products that were screened against existing databases for peptide bioactivities, toxicity, bitterness, stability in the intestine and in the blood, and novelty. Five peptide candidates were shortlisted showing antidiabetic, anti-inflammatory, antihypertensive, antimicrobial, and anticancer potential. By employing this approach, oyster BAPs were identified at a faster rate, with a wider applicability reach. With the growing market for peptide-based nutraceuticals, this provides an efficient workflow for candidate scouting and end-use investigation for targeted functional product preparation. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific Molecules 28 2 651 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Organic chemistry QD241-441 |
spellingShingle |
in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Organic chemistry QD241-441 Leyi Zhou Rufa L. Mendez Jung Yeon Kwon In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
topic_facet |
in silico prospecting bioactive peptides seafood Crassostrea gigas oyster proteins Organic chemistry QD241-441 |
description |
Pacific oyster ( Crassostrea gigas ), an abundant bivalve consumed across the Pacific, is known to possess a wide range of bioactivities. While there has been some work on its bioactive hydrolysates, the discovery of bioactive peptides (BAPs) remains limited due to the resource-intensive nature of the existing discovery pipeline. To overcome this constraint, in silico-based prospecting is employed to accelerate BAP discovery. Major oyster proteins were digested virtually under a simulated gastrointestinal condition to generate virtual peptide products that were screened against existing databases for peptide bioactivities, toxicity, bitterness, stability in the intestine and in the blood, and novelty. Five peptide candidates were shortlisted showing antidiabetic, anti-inflammatory, antihypertensive, antimicrobial, and anticancer potential. By employing this approach, oyster BAPs were identified at a faster rate, with a wider applicability reach. With the growing market for peptide-based nutraceuticals, this provides an efficient workflow for candidate scouting and end-use investigation for targeted functional product preparation. |
format |
Article in Journal/Newspaper |
author |
Leyi Zhou Rufa L. Mendez Jung Yeon Kwon |
author_facet |
Leyi Zhou Rufa L. Mendez Jung Yeon Kwon |
author_sort |
Leyi Zhou |
title |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
title_short |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
title_full |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
title_fullStr |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
title_full_unstemmed |
In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster ( Crassostrea gigas ) |
title_sort |
in silico prospecting for novel bioactive peptides from seafoods: a case study on pacific oyster ( crassostrea gigas ) |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/molecules28020651 https://doaj.org/article/f16bd7613ff1436aaf858b03ae6c1576 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Molecules, Vol 28, Iss 651, p 651 (2023) |
op_relation |
https://www.mdpi.com/1420-3049/28/2/651 https://doaj.org/toc/1420-3049 doi:10.3390/molecules28020651 1420-3049 https://doaj.org/article/f16bd7613ff1436aaf858b03ae6c1576 |
op_doi |
https://doi.org/10.3390/molecules28020651 |
container_title |
Molecules |
container_volume |
28 |
container_issue |
2 |
container_start_page |
651 |
_version_ |
1766393245071310848 |