Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners
Background & objectives: Immune activation and inflammation play critical roles in the stressful environmental conditions like high altitude, extreme cold, etc. Human leukocyte antigen-G (HLA-G) is a non classical major histocompatiblity complex class I (MHC class- I) protein, upregulated in the...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:f16551fc420843d3bebbda8fed2c112a 2023-05-15T13:38:28+02:00 Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners K P Mishra A P Yadav Y K Sharma Lilly Ganju S B Singh 2014-01-01T00:00:00Z https://doaj.org/article/f16551fc420843d3bebbda8fed2c112a EN eng Wolters Kluwer Medknow Publications http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=4;spage=520;epage=523;aulast=Mishra https://doaj.org/toc/0971-5916 0971-5916 https://doaj.org/article/f16551fc420843d3bebbda8fed2c112a Indian Journal of Medical Research, Vol 140, Iss 4, Pp 520-523 (2014) Antarctica - expeditioners - HLA-G - inflammation - serum - ship Medicine R article 2014 ftdoajarticles 2022-12-31T13:02:45Z Background & objectives: Immune activation and inflammation play critical roles in the stressful environmental conditions like high altitude, extreme cold, etc. Human leukocyte antigen-G (HLA-G) is a non classical major histocompatiblity complex class I (MHC class- I) protein, upregulated in the context of transplantation, malignancy and inflammation. We hypothesized serum HLA-G as a possible stress biomarker and studied levels of soluble form of HLA-G (sHLA-G) in Indian Antarctic expeditioners. Methods: sHLA-G ELISA was performed in the serum of summer (n=27) and winter (n=22) Indian Antarctic expeditioners. The summer expeditioners were evaluated at three different time points, i.e. before leaving India, after one month ship borne journey, and after staying one month at Indian research base, Maitri in Antarctica, while winter expeditioners were evaluated at five different time points, i.e. before leaving India, and in the month of March, May, August and November at Antarctica. Results: o0 ne month ship borne journey did not cause any significant change in the sHLA-G level as compared to the baseline level of the summer expeditioners. sHLA-G levels were not changed significantly in the months of March, May, August and November as compared to the baseline level of the winter expeditioners. Interpretation & conclusions: Our results indicated that the extreme conditions of Antarctica did not cause any significant change in the sHLA-G level in both summer and winter expeditioners. Article in Journal/Newspaper Antarc* Antarctic Antarctica Directory of Open Access Journals: DOAJ Articles Antarctic Indian Maitri ENVELOPE(11.733,11.733,-70.764,-70.764) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Antarctica - expeditioners - HLA-G - inflammation - serum - ship Medicine R |
spellingShingle |
Antarctica - expeditioners - HLA-G - inflammation - serum - ship Medicine R K P Mishra A P Yadav Y K Sharma Lilly Ganju S B Singh Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
topic_facet |
Antarctica - expeditioners - HLA-G - inflammation - serum - ship Medicine R |
description |
Background & objectives: Immune activation and inflammation play critical roles in the stressful environmental conditions like high altitude, extreme cold, etc. Human leukocyte antigen-G (HLA-G) is a non classical major histocompatiblity complex class I (MHC class- I) protein, upregulated in the context of transplantation, malignancy and inflammation. We hypothesized serum HLA-G as a possible stress biomarker and studied levels of soluble form of HLA-G (sHLA-G) in Indian Antarctic expeditioners. Methods: sHLA-G ELISA was performed in the serum of summer (n=27) and winter (n=22) Indian Antarctic expeditioners. The summer expeditioners were evaluated at three different time points, i.e. before leaving India, after one month ship borne journey, and after staying one month at Indian research base, Maitri in Antarctica, while winter expeditioners were evaluated at five different time points, i.e. before leaving India, and in the month of March, May, August and November at Antarctica. Results: o0 ne month ship borne journey did not cause any significant change in the sHLA-G level as compared to the baseline level of the summer expeditioners. sHLA-G levels were not changed significantly in the months of March, May, August and November as compared to the baseline level of the winter expeditioners. Interpretation & conclusions: Our results indicated that the extreme conditions of Antarctica did not cause any significant change in the sHLA-G level in both summer and winter expeditioners. |
format |
Article in Journal/Newspaper |
author |
K P Mishra A P Yadav Y K Sharma Lilly Ganju S B Singh |
author_facet |
K P Mishra A P Yadav Y K Sharma Lilly Ganju S B Singh |
author_sort |
K P Mishra |
title |
Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
title_short |
Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
title_full |
Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
title_fullStr |
Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
title_full_unstemmed |
Effect of extreme conditions of Antarctica on human leukocyte antigen-G in Indian expeditioners |
title_sort |
effect of extreme conditions of antarctica on human leukocyte antigen-g in indian expeditioners |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doaj.org/article/f16551fc420843d3bebbda8fed2c112a |
long_lat |
ENVELOPE(11.733,11.733,-70.764,-70.764) |
geographic |
Antarctic Indian Maitri |
geographic_facet |
Antarctic Indian Maitri |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Indian Journal of Medical Research, Vol 140, Iss 4, Pp 520-523 (2014) |
op_relation |
http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2014;volume=140;issue=4;spage=520;epage=523;aulast=Mishra https://doaj.org/toc/0971-5916 0971-5916 https://doaj.org/article/f16551fc420843d3bebbda8fed2c112a |
_version_ |
1766106533208260608 |