Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus.
West Nile virus (WNV) is a mosquito-borne flavivirus that infects humans and other mammals. In some cases WNV causes severe neurological disease. During recent years, outbreaks of WNV are increasing in worldwide distribution and novel genetic variants of the virus have been detected. Although a subs...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0002797 https://doaj.org/article/f1488cb1f28344219cd283a660cf2d97 |
id |
ftdoajarticles:oai:doaj.org/article:f1488cb1f28344219cd283a660cf2d97 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f1488cb1f28344219cd283a660cf2d97 2023-05-15T15:08:05+02:00 Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. Babs E Verstrepen Zahra Fagrouch Melanie van Heteren Hester Buitendijk Tom Haaksma Niels Beenhakker Giorgio Palù Justin M Richner Michael S Diamond Willy M Bogers Luisa Barzon Stefan Chabierski Sebastian Ulbert Ivanela Kondova Ernst J Verschoor 2014-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002797 https://doaj.org/article/f1488cb1f28344219cd283a660cf2d97 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3990483?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002797 https://doaj.org/article/f1488cb1f28344219cd283a660cf2d97 PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2797 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002797 2022-12-31T14:11:43Z West Nile virus (WNV) is a mosquito-borne flavivirus that infects humans and other mammals. In some cases WNV causes severe neurological disease. During recent years, outbreaks of WNV are increasing in worldwide distribution and novel genetic variants of the virus have been detected. Although a substantial amount of data exists on WNV infections in rodent models, little is known about early events during WNV infection in primates, including humans. To gain a deeper understanding of this process, we performed experimental infections of rhesus macaques and common marmosets with a virulent European WNV strain (WNV-Ita09) and monitored virological, hematological, and biochemical parameters. WNV-Ita09 productively infected both monkey species, with higher replication and wider tissue distribution in common marmosets compared to rhesus macaques. The animals in this study however, did not develop clinical signs of WNV disease, nor showed substantial deviations in clinical laboratory parameters. In both species, the virus induced a rapid CD56dimCD16bright natural killer response, followed by IgM and IgG antibody responses. The results of this study show that healthy rhesus macaques and common marmosets are promising animal models to study WNV-Ita09 infection. Both models may be particularly of use to evaluate potential vaccine candidates or to investigate WNV pathogenesis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 4 e2797 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Babs E Verstrepen Zahra Fagrouch Melanie van Heteren Hester Buitendijk Tom Haaksma Niels Beenhakker Giorgio Palù Justin M Richner Michael S Diamond Willy M Bogers Luisa Barzon Stefan Chabierski Sebastian Ulbert Ivanela Kondova Ernst J Verschoor Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
West Nile virus (WNV) is a mosquito-borne flavivirus that infects humans and other mammals. In some cases WNV causes severe neurological disease. During recent years, outbreaks of WNV are increasing in worldwide distribution and novel genetic variants of the virus have been detected. Although a substantial amount of data exists on WNV infections in rodent models, little is known about early events during WNV infection in primates, including humans. To gain a deeper understanding of this process, we performed experimental infections of rhesus macaques and common marmosets with a virulent European WNV strain (WNV-Ita09) and monitored virological, hematological, and biochemical parameters. WNV-Ita09 productively infected both monkey species, with higher replication and wider tissue distribution in common marmosets compared to rhesus macaques. The animals in this study however, did not develop clinical signs of WNV disease, nor showed substantial deviations in clinical laboratory parameters. In both species, the virus induced a rapid CD56dimCD16bright natural killer response, followed by IgM and IgG antibody responses. The results of this study show that healthy rhesus macaques and common marmosets are promising animal models to study WNV-Ita09 infection. Both models may be particularly of use to evaluate potential vaccine candidates or to investigate WNV pathogenesis. |
format |
Article in Journal/Newspaper |
author |
Babs E Verstrepen Zahra Fagrouch Melanie van Heteren Hester Buitendijk Tom Haaksma Niels Beenhakker Giorgio Palù Justin M Richner Michael S Diamond Willy M Bogers Luisa Barzon Stefan Chabierski Sebastian Ulbert Ivanela Kondova Ernst J Verschoor |
author_facet |
Babs E Verstrepen Zahra Fagrouch Melanie van Heteren Hester Buitendijk Tom Haaksma Niels Beenhakker Giorgio Palù Justin M Richner Michael S Diamond Willy M Bogers Luisa Barzon Stefan Chabierski Sebastian Ulbert Ivanela Kondova Ernst J Verschoor |
author_sort |
Babs E Verstrepen |
title |
Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
title_short |
Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
title_full |
Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
title_fullStr |
Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
title_full_unstemmed |
Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. |
title_sort |
experimental infection of rhesus macaques and common marmosets with a european strain of west nile virus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0002797 https://doaj.org/article/f1488cb1f28344219cd283a660cf2d97 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 4, p e2797 (2014) |
op_relation |
http://europepmc.org/articles/PMC3990483?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002797 https://doaj.org/article/f1488cb1f28344219cd283a660cf2d97 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002797 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
4 |
container_start_page |
e2797 |
_version_ |
1766339513407242240 |