IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY
Background. For the proper diagnosis and optimal prognosis of acute leukemia (AL), a complex of clinical and laboratory methods is used. Among them, chromosomal analysis plays an important role. Cytogenetic markers of leukemic cells are widely used in clinical settings. WHO classification of Tumors...
Published in: | Siberian journal of oncology |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2021
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Online Access: | https://doi.org/10.21294/1814-4861-2021-20-2-13-21 https://doaj.org/article/f0a9481df2964003b101c09dcc2ecd62 |
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ftdoajarticles:oai:doaj.org/article:f0a9481df2964003b101c09dcc2ecd62 2023-05-15T15:23:38+02:00 IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY A. S. Ulanova A. V. Kudryavtsev A. L. Turabova N. A. Grigorieva I. A. Turabov M. Yu. Rykov 2021-05-01T00:00:00Z https://doi.org/10.21294/1814-4861-2021-20-2-13-21 https://doaj.org/article/f0a9481df2964003b101c09dcc2ecd62 RU rus Russian Academy of Sciences, Tomsk National Research Medical Center https://www.siboncoj.ru/jour/article/view/1749 https://doaj.org/toc/1814-4861 https://doaj.org/toc/2312-3168 1814-4861 2312-3168 doi:10.21294/1814-4861-2021-20-2-13-21 https://doaj.org/article/f0a9481df2964003b101c09dcc2ecd62 Сибирский онкологический журнал, Vol 20, Iss 2, Pp 13-21 (2021) острый лимфобластный лейкоз у детей иммунофенотипирование цитогенетическое исследование транслокации Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2021 ftdoajarticles https://doi.org/10.21294/1814-4861-2021-20-2-13-21 2023-03-19T01:38:07Z Background. For the proper diagnosis and optimal prognosis of acute leukemia (AL), a complex of clinical and laboratory methods is used. Among them, chromosomal analysis plays an important role. Cytogenetic markers of leukemic cells are widely used in clinical settings. WHO classification of Tumors of Haematopoietic and Lymphoid Tissues is based on a combined analysis of clinical, cytomorphological, immunophenotypic and cytogenetic findings. Immunophenotyping of blast cells using monoclonal antibodies has significantly improved the diagnosis of leukemia by detecting the grade of tumor differentiation. Aim: based on the results of immunophenotypic and cytogenetic examinations, to describe the structure of AL and to study the effect of cytogenetic abnormalities on the prognosis of acute leukemia in the child population of the Arkhangelsk region.Material and Methods. Archived data were used to analyze the results of cytogenetic and immunophenotypic examinations of all children aged 0–17 years in the Arkhangelsk region, who were diagnosed with AL in the period from January, 2004 to december, 2018. Results. Immunophenotypic examination of bone marrow blast cells in patients with AL revealed that B-linear lymphoblastic leukemia was the most common (74.8 %). Among the quantitative anomalies, hyperploidy was the most common (additional chromosomes 4, 10 and 17 were observed). The t(12; 21) was the most frequent structural chromosomal abnormality. The philadelphia chromosome (ph) (9;22) was found in 6.5 % of cases. The highest risk of death was observed in AL patients with the acute myeloid leukemia phenotype (p<0.001). The overall survival in AL patients significantly improved over the study period (p<0.001). Conclusion. No specific differences in the structure of chromosomal abnormalities were detected. All chromosomal abnormalities which usually have negative effects on the prognosis of the disease also showed negative impacts on the prognosis. Survival of AL patients significantly increased over the study ... Article in Journal/Newspaper Arkhangelsk Directory of Open Access Journals: DOAJ Articles Siberian journal of oncology 20 2 13 21 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
острый лимфобластный лейкоз у детей иммунофенотипирование цитогенетическое исследование транслокации Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
острый лимфобластный лейкоз у детей иммунофенотипирование цитогенетическое исследование транслокации Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 A. S. Ulanova A. V. Kudryavtsev A. L. Turabova N. A. Grigorieva I. A. Turabov M. Yu. Rykov IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
topic_facet |
острый лимфобластный лейкоз у детей иммунофенотипирование цитогенетическое исследование транслокации Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Background. For the proper diagnosis and optimal prognosis of acute leukemia (AL), a complex of clinical and laboratory methods is used. Among them, chromosomal analysis plays an important role. Cytogenetic markers of leukemic cells are widely used in clinical settings. WHO classification of Tumors of Haematopoietic and Lymphoid Tissues is based on a combined analysis of clinical, cytomorphological, immunophenotypic and cytogenetic findings. Immunophenotyping of blast cells using monoclonal antibodies has significantly improved the diagnosis of leukemia by detecting the grade of tumor differentiation. Aim: based on the results of immunophenotypic and cytogenetic examinations, to describe the structure of AL and to study the effect of cytogenetic abnormalities on the prognosis of acute leukemia in the child population of the Arkhangelsk region.Material and Methods. Archived data were used to analyze the results of cytogenetic and immunophenotypic examinations of all children aged 0–17 years in the Arkhangelsk region, who were diagnosed with AL in the period from January, 2004 to december, 2018. Results. Immunophenotypic examination of bone marrow blast cells in patients with AL revealed that B-linear lymphoblastic leukemia was the most common (74.8 %). Among the quantitative anomalies, hyperploidy was the most common (additional chromosomes 4, 10 and 17 were observed). The t(12; 21) was the most frequent structural chromosomal abnormality. The philadelphia chromosome (ph) (9;22) was found in 6.5 % of cases. The highest risk of death was observed in AL patients with the acute myeloid leukemia phenotype (p<0.001). The overall survival in AL patients significantly improved over the study period (p<0.001). Conclusion. No specific differences in the structure of chromosomal abnormalities were detected. All chromosomal abnormalities which usually have negative effects on the prognosis of the disease also showed negative impacts on the prognosis. Survival of AL patients significantly increased over the study ... |
format |
Article in Journal/Newspaper |
author |
A. S. Ulanova A. V. Kudryavtsev A. L. Turabova N. A. Grigorieva I. A. Turabov M. Yu. Rykov |
author_facet |
A. S. Ulanova A. V. Kudryavtsev A. L. Turabova N. A. Grigorieva I. A. Turabov M. Yu. Rykov |
author_sort |
A. S. Ulanova |
title |
IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
title_short |
IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
title_full |
IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
title_fullStr |
IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
title_full_unstemmed |
IMMUNOPHENOTYPIC AND CYTOGENETIC FEATURES OF ACUTE LEUKEMIA IN CHILDREN OF THE ARKHANGELSK REGION: A RETROSPECTIVE STUDYN: A RETROSPECTIVE STUDY |
title_sort |
immunophenotypic and cytogenetic features of acute leukemia in children of the arkhangelsk region: a retrospective studyn: a retrospective study |
publisher |
Russian Academy of Sciences, Tomsk National Research Medical Center |
publishDate |
2021 |
url |
https://doi.org/10.21294/1814-4861-2021-20-2-13-21 https://doaj.org/article/f0a9481df2964003b101c09dcc2ecd62 |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_source |
Сибирский онкологический журнал, Vol 20, Iss 2, Pp 13-21 (2021) |
op_relation |
https://www.siboncoj.ru/jour/article/view/1749 https://doaj.org/toc/1814-4861 https://doaj.org/toc/2312-3168 1814-4861 2312-3168 doi:10.21294/1814-4861-2021-20-2-13-21 https://doaj.org/article/f0a9481df2964003b101c09dcc2ecd62 |
op_doi |
https://doi.org/10.21294/1814-4861-2021-20-2-13-21 |
container_title |
Siberian journal of oncology |
container_volume |
20 |
container_issue |
2 |
container_start_page |
13 |
op_container_end_page |
21 |
_version_ |
1766354294890561536 |