A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults
Abstract Background Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-9-302 https://doaj.org/article/f096307c2f824df093cc062c9561934b |
id |
ftdoajarticles:oai:doaj.org/article:f096307c2f824df093cc062c9561934b |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:f096307c2f824df093cc062c9561934b 2023-05-15T15:07:36+02:00 A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults Granger Donald L Salwati Ervi Woodberry Tonia Stanley Amanda C Haque Ashraful Amante Fiona H Le Lien McSweeney Karli M Zhou Yonghong de Labastida Rivera Fabian Zhao Zhen Z Piera Kim A Handojo Tjandra Mwaikambo Esther D Tjitra Emiliana Lampah Daniel A Kenangalem Enny Randall Louise M Hobbs Maurine R Price Ric N Weinberg J Brice Montgomery Grant W Anstey Nicholas M Engwerda Christian R 2010-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-302 https://doaj.org/article/f096307c2f824df093cc062c9561934b EN eng BMC http://www.malariajournal.com/content/9/1/302 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-302 1475-2875 https://doaj.org/article/f096307c2f824df093cc062c9561934b Malaria Journal, Vol 9, Iss 1, p 302 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-302 2022-12-31T09:15:25Z Abstract Background Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes. Methods An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated P -values for SNPs spanning the LTA/TNF/LTB locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global P-value of < 0.05 was considered statistically significant. Results No associations between SNPs in the TNF/LTA/LTB locus and susceptibility to SM in highland Papuan children and adults were found. Conclusions These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 302 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Granger Donald L Salwati Ervi Woodberry Tonia Stanley Amanda C Haque Ashraful Amante Fiona H Le Lien McSweeney Karli M Zhou Yonghong de Labastida Rivera Fabian Zhao Zhen Z Piera Kim A Handojo Tjandra Mwaikambo Esther D Tjitra Emiliana Lampah Daniel A Kenangalem Enny Randall Louise M Hobbs Maurine R Price Ric N Weinberg J Brice Montgomery Grant W Anstey Nicholas M Engwerda Christian R A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Severe malaria (SM) syndromes caused by Plasmodium falciparum infection result in major morbidity and mortality each year. However, only a fraction of P. falciparum infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes. Methods An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the TNF, LTA and LTB genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated P -values for SNPs spanning the LTA/TNF/LTB locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global P-value of < 0.05 was considered statistically significant. Results No associations between SNPs in the TNF/LTA/LTB locus and susceptibility to SM in highland Papuan children and adults were found. Conclusions These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility. |
format |
Article in Journal/Newspaper |
author |
Granger Donald L Salwati Ervi Woodberry Tonia Stanley Amanda C Haque Ashraful Amante Fiona H Le Lien McSweeney Karli M Zhou Yonghong de Labastida Rivera Fabian Zhao Zhen Z Piera Kim A Handojo Tjandra Mwaikambo Esther D Tjitra Emiliana Lampah Daniel A Kenangalem Enny Randall Louise M Hobbs Maurine R Price Ric N Weinberg J Brice Montgomery Grant W Anstey Nicholas M Engwerda Christian R |
author_facet |
Granger Donald L Salwati Ervi Woodberry Tonia Stanley Amanda C Haque Ashraful Amante Fiona H Le Lien McSweeney Karli M Zhou Yonghong de Labastida Rivera Fabian Zhao Zhen Z Piera Kim A Handojo Tjandra Mwaikambo Esther D Tjitra Emiliana Lampah Daniel A Kenangalem Enny Randall Louise M Hobbs Maurine R Price Ric N Weinberg J Brice Montgomery Grant W Anstey Nicholas M Engwerda Christian R |
author_sort |
Granger Donald L |
title |
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
title_short |
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
title_full |
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
title_fullStr |
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
title_full_unstemmed |
A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults |
title_sort |
study of the tnf/lta/ltb locus and susceptibility to severe malaria in highland papuan children and adults |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-302 https://doaj.org/article/f096307c2f824df093cc062c9561934b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 302 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/302 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-302 1475-2875 https://doaj.org/article/f096307c2f824df093cc062c9561934b |
op_doi |
https://doi.org/10.1186/1475-2875-9-302 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
container_start_page |
302 |
_version_ |
1766339067553775616 |