Entomophthoramycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole

• Main Authors: Antonio Carlos Francesconi do VALLE, Bodo WANKE, Márcia dos Santos LAZÉRA, Paulo Cezar Fialho MONTEIRO, Maria de Lourdes VIEGAS
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2001
• Subjects: Entomophthoramycosis; Zygomycosis; Combination triazole treatment; Rhinoentomophthoramycosis; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doaj.org/article/f05a08dc5c16415e8310ca1c4b08d7a7

Rhinoentomophthoramycosis caused by Conidiobolus coronatus in a 61-year old woman was unsuccessfully treated during 8 years with all the antifungals available in the Brazilian market, including potassium iodide for 1 month, sulfamethoxazole plus trimethoprim for 2 months, amphotericin B, total dose of 1130 mg, cetoconazole, 400 mg/day for 6 months, fluconazole, 200 mg/day, for at least 2 months and, itraconazole, 400 mg/day for 2 months, followed by 200 mg/day for 4 more months. Complete clinical and mycological cure was achieved using itraconazol 400 mg/day in association with fluconazol 200 mg/day during 24 months. After cure she was submitted to plastic surgery to repair her facial deformation. Today she remains clinically and mycologically cured after 59/60 months (5 years!) without any specific antifungal. We thus suggest the use of the combination of itraconazole and fluconazole as an additional option for the treatment of this mycosis.