First report of a blaNDM-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Cynthia Regina Pedrosa Soares, Jorge Belém Oliveira-Júnior, Elza Ferreira Firmo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2020
• Subjects: Klebsiella aerogenes; bla NDM gene; metallo-betalactamase; Carbapenemase; Multidrug-resistant; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0262-2020; https://doaj.org/article/f044f1a7430d4c6e8db8af21a5534f67

Abstract INTRODUCTION: Carbapenemase-resistant enterobacteria that produce the bla NDM gene are found worldwide. However, this is the first report of blaNDM in Klebsiella aerogenes in Brazil. METHODS: The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. RESULTS: The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the blaNDM gene was detected. CONCLUSIONS: The current report of the blaNDM gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting.