Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil
Abstract INTRODUCTION: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemo...
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ftdoajarticles:oai:doaj.org/article:efff64d946154d7b9b08f91a6ac02dfd 2023-05-15T15:11:29+02:00 Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil Ralph Antonio Xavier Ferreira Claire Fernandes Kubelka Luis Guillermo Coca Velarde Jorge Paulo Strogoff de Matos Laura Cunha Ferreira Mariana Mancebo Reid Sérgio Setúbal Solange Artimos de Oliveira https://doi.org/10.1590/0037-8682-0036-2018 https://doaj.org/article/efff64d946154d7b9b08f91a6ac02dfd EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000600753&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0036-2018 https://doaj.org/article/efff64d946154d7b9b08f91a6ac02dfd Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 6, Pp 753-760 Severe dengue Dengue hemorrhagic fever Predictive factors Children Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0036-2018 2022-12-31T03:21:05Z Abstract INTRODUCTION: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. METHODS: A cross-sectional analytical study was conducted to examine laboratory diagnosis and clinical epidemiologic factors for confirmed dengue cases in patients aged less than 16 years, from January to June 2008, at a municipal hospital in the City of Rio de Janeiro, Brazil. Variables associated with severe outcomes and P values less than .05 were evaluated by means of a logistic regression model. RESULTS: Of the 419 dengue cases studied, 296 were classified as DHF and 123 as classical dengue. Six patients who had DHF died. In multivariate analysis, some laboratory and clinical variables were independently associated with DHF: age 5 years or older (odds ratio [OR], 4.94; 95% confidence interval [CI], 1.30-18.71), abdominal pain (OR, 8.59; 95% CI, 3.17-23.27), hepatomegaly (OR, 15.87; 95% CI, 5.38-46.85), and positive tourniquet test (OR, 10.84; 95% CI, 3.96-29.71). Hypoalbuminemia occurred more frequently than hemoconcentration in DHF cases, and high aminotransferase levels were associated with severity. CONCLUSIONS: Age greater than 5 years, abdominal pain, painful hepatomegaly, and positive tourniquet test were predictors of DHF. The high frequency of hepatic impairment suggests that acetaminophen should be avoided in severe cases of dengue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 51 6 753 760 |
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Directory of Open Access Journals: DOAJ Articles |
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Severe dengue Dengue hemorrhagic fever Predictive factors Children Arctic medicine. Tropical medicine RC955-962 |
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Severe dengue Dengue hemorrhagic fever Predictive factors Children Arctic medicine. Tropical medicine RC955-962 Ralph Antonio Xavier Ferreira Claire Fernandes Kubelka Luis Guillermo Coca Velarde Jorge Paulo Strogoff de Matos Laura Cunha Ferreira Mariana Mancebo Reid Sérgio Setúbal Solange Artimos de Oliveira Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
topic_facet |
Severe dengue Dengue hemorrhagic fever Predictive factors Children Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. METHODS: A cross-sectional analytical study was conducted to examine laboratory diagnosis and clinical epidemiologic factors for confirmed dengue cases in patients aged less than 16 years, from January to June 2008, at a municipal hospital in the City of Rio de Janeiro, Brazil. Variables associated with severe outcomes and P values less than .05 were evaluated by means of a logistic regression model. RESULTS: Of the 419 dengue cases studied, 296 were classified as DHF and 123 as classical dengue. Six patients who had DHF died. In multivariate analysis, some laboratory and clinical variables were independently associated with DHF: age 5 years or older (odds ratio [OR], 4.94; 95% confidence interval [CI], 1.30-18.71), abdominal pain (OR, 8.59; 95% CI, 3.17-23.27), hepatomegaly (OR, 15.87; 95% CI, 5.38-46.85), and positive tourniquet test (OR, 10.84; 95% CI, 3.96-29.71). Hypoalbuminemia occurred more frequently than hemoconcentration in DHF cases, and high aminotransferase levels were associated with severity. CONCLUSIONS: Age greater than 5 years, abdominal pain, painful hepatomegaly, and positive tourniquet test were predictors of DHF. The high frequency of hepatic impairment suggests that acetaminophen should be avoided in severe cases of dengue. |
format |
Article in Journal/Newspaper |
author |
Ralph Antonio Xavier Ferreira Claire Fernandes Kubelka Luis Guillermo Coca Velarde Jorge Paulo Strogoff de Matos Laura Cunha Ferreira Mariana Mancebo Reid Sérgio Setúbal Solange Artimos de Oliveira |
author_facet |
Ralph Antonio Xavier Ferreira Claire Fernandes Kubelka Luis Guillermo Coca Velarde Jorge Paulo Strogoff de Matos Laura Cunha Ferreira Mariana Mancebo Reid Sérgio Setúbal Solange Artimos de Oliveira |
author_sort |
Ralph Antonio Xavier Ferreira |
title |
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
title_short |
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
title_full |
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
title_fullStr |
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
title_full_unstemmed |
Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil |
title_sort |
predictive factors of dengue severity in hospitalized children and adolescents in rio de janeiro, brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0036-2018 https://doaj.org/article/efff64d946154d7b9b08f91a6ac02dfd |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 6, Pp 753-760 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000600753&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0036-2018 https://doaj.org/article/efff64d946154d7b9b08f91a6ac02dfd |
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https://doi.org/10.1590/0037-8682-0036-2018 |
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