Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego
This study evaluated the possibility of inoculation and reinoculation with a trypanosomatid isolated from bats that is morphologically, biologically and molecularly similar to Trypanosoma cruzi, to protect against infection by virulent strains. Non-isogenic mice were divided into 24 groups that rece...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2008
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Online Access: | https://doi.org/10.1590/S0037-86822008000200004 https://doaj.org/article/efe3950b3d6349048dbaee92f3359976 |
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ftdoajarticles:oai:doaj.org/article:efe3950b3d6349048dbaee92f3359976 2023-05-15T15:17:09+02:00 Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego Gabriel Antonio Nogueira Nascentes Wendell Sérgio Ferreira Meira Eliane Lages-Silva Luis Eduardo Ramírez 2008-04-01T00:00:00Z https://doi.org/10.1590/S0037-86822008000200004 https://doaj.org/article/efe3950b3d6349048dbaee92f3359976 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000200004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822008000200004 0037-8682 1678-9849 https://doaj.org/article/efe3950b3d6349048dbaee92f3359976 Revista da Sociedade Brasileira de Medicina Tropical, Vol 41, Iss 2, Pp 152-157 (2008) Trypanosoma cruzi Trypanosoma cruzi-like Tripanossomatídeos de morcego Proteção cruzada Eosinófilos Bat trypanosomatids Cross-protection Eosinophils Arctic medicine. Tropical medicine RC955-962 article 2008 ftdoajarticles https://doi.org/10.1590/S0037-86822008000200004 2022-12-30T21:27:05Z This study evaluated the possibility of inoculation and reinoculation with a trypanosomatid isolated from bats that is morphologically, biologically and molecularly similar to Trypanosoma cruzi, to protect against infection by virulent strains. Non-isogenic mice were divided into 24 groups that received from zero to three inoculations of Trypanosoma cruzi-like strain RM1, in the presence or absence of Freund's adjuvant, and were challenged with the VIC or JG strains of Trypanosoma cruzi. Parasitemia and survival were monitored and animals were sacrificed for histopathological analysis. Animals immunized with Trypanosoma cruzi-like strain RM1 presented decreased parasitemia, independently of the number of inoculations or the presence of adjuvant. In spite of this reduction, these animals did not present any protection against histopathological lesions. Severe eosinophilic infiltrate was observed and was correlated with the number of inoculations of Trypanosoma cruzi-like strain RM1. These findings suggest that prior inoculation with this strain did not protect against infection but, rather, aggravated the tissue inflammatory process. Este trabalho avaliou a possibilidade da inoculação e reinoculação de um tripanossomatídeo isolado de morcego, morfológica, biológica e molecularmente semelhante ao Trypanosoma cruzi, na proteção contra a infecção por cepas virulentas. Camundongos não-isogênicos foram divididos em 24 grupos, que receberam de zero a três inóculos da cepa RM1 de Trypanosoma cruzi-like, na presença ou ausência de adjuvante de Freund e desafiados com as cepas de Trypanosoma cruzi VIC ou JG. Acompanhou-se a parasitemia e a sobrevida e os camundongos foram sacrificados para análise histopatológica. Os animais imunizados com a cepa RM1 de Trypanosoma cruzi-like apresentaram redução da parasitemia, independente do número de inóculos ou presença de adjuvante. Apesar dessa redução, os animais não apresentaram proteção contra lesões histopatológicas e observaram-se intensos infiltrados eosinofílicos que foram ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 41 2 152 157 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Trypanosoma cruzi Trypanosoma cruzi-like Tripanossomatídeos de morcego Proteção cruzada Eosinófilos Bat trypanosomatids Cross-protection Eosinophils Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Trypanosoma cruzi Trypanosoma cruzi-like Tripanossomatídeos de morcego Proteção cruzada Eosinófilos Bat trypanosomatids Cross-protection Eosinophils Arctic medicine. Tropical medicine RC955-962 Gabriel Antonio Nogueira Nascentes Wendell Sérgio Ferreira Meira Eliane Lages-Silva Luis Eduardo Ramírez Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
topic_facet |
Trypanosoma cruzi Trypanosoma cruzi-like Tripanossomatídeos de morcego Proteção cruzada Eosinófilos Bat trypanosomatids Cross-protection Eosinophils Arctic medicine. Tropical medicine RC955-962 |
description |
This study evaluated the possibility of inoculation and reinoculation with a trypanosomatid isolated from bats that is morphologically, biologically and molecularly similar to Trypanosoma cruzi, to protect against infection by virulent strains. Non-isogenic mice were divided into 24 groups that received from zero to three inoculations of Trypanosoma cruzi-like strain RM1, in the presence or absence of Freund's adjuvant, and were challenged with the VIC or JG strains of Trypanosoma cruzi. Parasitemia and survival were monitored and animals were sacrificed for histopathological analysis. Animals immunized with Trypanosoma cruzi-like strain RM1 presented decreased parasitemia, independently of the number of inoculations or the presence of adjuvant. In spite of this reduction, these animals did not present any protection against histopathological lesions. Severe eosinophilic infiltrate was observed and was correlated with the number of inoculations of Trypanosoma cruzi-like strain RM1. These findings suggest that prior inoculation with this strain did not protect against infection but, rather, aggravated the tissue inflammatory process. Este trabalho avaliou a possibilidade da inoculação e reinoculação de um tripanossomatídeo isolado de morcego, morfológica, biológica e molecularmente semelhante ao Trypanosoma cruzi, na proteção contra a infecção por cepas virulentas. Camundongos não-isogênicos foram divididos em 24 grupos, que receberam de zero a três inóculos da cepa RM1 de Trypanosoma cruzi-like, na presença ou ausência de adjuvante de Freund e desafiados com as cepas de Trypanosoma cruzi VIC ou JG. Acompanhou-se a parasitemia e a sobrevida e os camundongos foram sacrificados para análise histopatológica. Os animais imunizados com a cepa RM1 de Trypanosoma cruzi-like apresentaram redução da parasitemia, independente do número de inóculos ou presença de adjuvante. Apesar dessa redução, os animais não apresentaram proteção contra lesões histopatológicas e observaram-se intensos infiltrados eosinofílicos que foram ... |
format |
Article in Journal/Newspaper |
author |
Gabriel Antonio Nogueira Nascentes Wendell Sérgio Ferreira Meira Eliane Lages-Silva Luis Eduardo Ramírez |
author_facet |
Gabriel Antonio Nogueira Nascentes Wendell Sérgio Ferreira Meira Eliane Lages-Silva Luis Eduardo Ramírez |
author_sort |
Gabriel Antonio Nogueira Nascentes |
title |
Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
title_short |
Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
title_full |
Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
title_fullStr |
Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
title_full_unstemmed |
Absence of experimental cross-protection induced by a Trypanosoma cruzi-like strain isolated from bats Ausência de proteção cruzada experimental induzida por uma cepa Trypanosoma cruzi-like isolada de morcego |
title_sort |
absence of experimental cross-protection induced by a trypanosoma cruzi-like strain isolated from bats ausência de proteção cruzada experimental induzida por uma cepa trypanosoma cruzi-like isolada de morcego |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2008 |
url |
https://doi.org/10.1590/S0037-86822008000200004 https://doaj.org/article/efe3950b3d6349048dbaee92f3359976 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 41, Iss 2, Pp 152-157 (2008) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000200004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 doi:10.1590/S0037-86822008000200004 0037-8682 1678-9849 https://doaj.org/article/efe3950b3d6349048dbaee92f3359976 |
op_doi |
https://doi.org/10.1590/S0037-86822008000200004 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
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41 |
container_issue |
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152 |
op_container_end_page |
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