Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study
Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients. Methods A cross-sectional st...
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ftdoajarticles:oai:doaj.org/article:efbce169de55491cbd2b1695ec2a027a 2023-05-15T15:17:17+02:00 Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study Samar Abd ElHafeez Reem Hegazy Yasmine Naga Iman Wahdan Sunny Sallam 2019-01-01T00:00:00Z https://doi.org/10.1186/s42506-018-0005-2 https://doaj.org/article/efbce169de55491cbd2b1695ec2a027a EN eng SpringerOpen http://link.springer.com/article/10.1186/s42506-018-0005-2 https://doaj.org/toc/2090-262X doi:10.1186/s42506-018-0005-2 2090-262X https://doaj.org/article/efbce169de55491cbd2b1695ec2a027a Journal of the Egyptian Public Health Association, Vol 94, Iss 1, Pp 1-8 (2019) NSAIDs CKD Epidemiology Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1186/s42506-018-0005-2 2022-12-31T15:19:23Z Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients. Methods A cross-sectional study was done among 350 CKD adult patients presented to the Main Alexandria University Hospital. Those with end-stage renal disease and diagnosed with acute renal injury and pregnant women were excluded. Demographic and clinical data were collected by interviewing eligible patients. Data about the pattern, history of drug-drug interactions, and knowledge about the NSAID side effects were also gathered. Results Of the enrolled patients, 57.1% were hypertensive, 46% were diabetics, 28% had osteoarthritis, and 18.3% had cardiovascular disease. CKD stages were 3.7%, 40.3%, and 56% in stages 2, 3, and 4, respectively. Almost two thirds (65.7%) were NSAID users. Among them, 82.6% were regular users. Headache was the most reported (68.7%) reason of use. The use of drugs which may have drug-drug interaction with the NSAIDs (as diuretics or renin-angiotensin-aldosterone system inhibitors) was reported in 36%. In multiple logistic regression, the odds of NSAID use decreased by 4% (odds ratio (OR) = 0.96, 95% confidence interval (CI) 0.93–0.99, p = 0.01) for every year increase in the patient’s age and decreased by 3% (OR = 0.97, 95% CI 0.95–0.99, p = 0.01) for every 1 ml/min/1.73 m2 increase in glomerular filtration rate. Conclusion Despite the hazards of NSAID use on the kidney, still high proportion of CKD patients are using them for a long period and they are simultaneously using other drugs with possible drug-drug interactions. This study provided important information that would decrease the gap in knowledge about the use of NSAID in Egypt. It is recommended that NSAIDs should be used with caution among CKD patients and patients should be advised about its adverse health consequences. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of the Egyptian Public Health Association 94 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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NSAIDs CKD Epidemiology Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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NSAIDs CKD Epidemiology Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Samar Abd ElHafeez Reem Hegazy Yasmine Naga Iman Wahdan Sunny Sallam Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
topic_facet |
NSAIDs CKD Epidemiology Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients. Methods A cross-sectional study was done among 350 CKD adult patients presented to the Main Alexandria University Hospital. Those with end-stage renal disease and diagnosed with acute renal injury and pregnant women were excluded. Demographic and clinical data were collected by interviewing eligible patients. Data about the pattern, history of drug-drug interactions, and knowledge about the NSAID side effects were also gathered. Results Of the enrolled patients, 57.1% were hypertensive, 46% were diabetics, 28% had osteoarthritis, and 18.3% had cardiovascular disease. CKD stages were 3.7%, 40.3%, and 56% in stages 2, 3, and 4, respectively. Almost two thirds (65.7%) were NSAID users. Among them, 82.6% were regular users. Headache was the most reported (68.7%) reason of use. The use of drugs which may have drug-drug interaction with the NSAIDs (as diuretics or renin-angiotensin-aldosterone system inhibitors) was reported in 36%. In multiple logistic regression, the odds of NSAID use decreased by 4% (odds ratio (OR) = 0.96, 95% confidence interval (CI) 0.93–0.99, p = 0.01) for every year increase in the patient’s age and decreased by 3% (OR = 0.97, 95% CI 0.95–0.99, p = 0.01) for every 1 ml/min/1.73 m2 increase in glomerular filtration rate. Conclusion Despite the hazards of NSAID use on the kidney, still high proportion of CKD patients are using them for a long period and they are simultaneously using other drugs with possible drug-drug interactions. This study provided important information that would decrease the gap in knowledge about the use of NSAID in Egypt. It is recommended that NSAIDs should be used with caution among CKD patients and patients should be advised about its adverse health consequences. |
format |
Article in Journal/Newspaper |
author |
Samar Abd ElHafeez Reem Hegazy Yasmine Naga Iman Wahdan Sunny Sallam |
author_facet |
Samar Abd ElHafeez Reem Hegazy Yasmine Naga Iman Wahdan Sunny Sallam |
author_sort |
Samar Abd ElHafeez |
title |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
title_short |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
title_full |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
title_fullStr |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
title_full_unstemmed |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
title_sort |
non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study |
publisher |
SpringerOpen |
publishDate |
2019 |
url |
https://doi.org/10.1186/s42506-018-0005-2 https://doaj.org/article/efbce169de55491cbd2b1695ec2a027a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of the Egyptian Public Health Association, Vol 94, Iss 1, Pp 1-8 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s42506-018-0005-2 https://doaj.org/toc/2090-262X doi:10.1186/s42506-018-0005-2 2090-262X https://doaj.org/article/efbce169de55491cbd2b1695ec2a027a |
op_doi |
https://doi.org/10.1186/s42506-018-0005-2 |
container_title |
Journal of the Egyptian Public Health Association |
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94 |
container_issue |
1 |
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1766347542452240384 |