Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik
Background: Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, w...
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ftdoajarticles:oai:doaj.org/article:ef62af78509a4e3c82526c4b37e519cd 2023-05-15T15:11:54+02:00 Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik Beatriz Valera Pierre Ayotte Paul Poirier Éric Dewailly 2013-09-01T00:00:00Z https://doi.org/10.1016/j.envint.2013.06.019 https://doaj.org/article/ef62af78509a4e3c82526c4b37e519cd EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S0160412013001372 https://doaj.org/toc/0160-4120 0160-4120 doi:10.1016/j.envint.2013.06.019 https://doaj.org/article/ef62af78509a4e3c82526c4b37e519cd Environment International, Vol 59, Iss , Pp 282-289 (2013) Environmental sciences GE1-350 article 2013 ftdoajarticles https://doi.org/10.1016/j.envint.2013.06.019 2022-12-31T02:15:13Z Background: Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations. Objective: We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada). Methods: A complete set of data was obtained for 315 Inuit ≥ 18 years who participated in the “Santé Québec” health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP ≥ 140 mm Hg, diastolic BP ≥ 90 mm Hg or anti-hypertensive medication) were analyzed using multiple logistic regressions. Results: Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n−3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT), β-hexachlorocyclohexane (HCH) and oxychlordane. Conclusions: Some PCB congeners were associated with higher risk of hypertension in this highly exposed ... Article in Journal/Newspaper Arctic inuit Nunavik Directory of Open Access Journals: DOAJ Articles Arctic Canada Nunavik Environment International 59 282 289 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Environmental sciences GE1-350 |
spellingShingle |
Environmental sciences GE1-350 Beatriz Valera Pierre Ayotte Paul Poirier Éric Dewailly Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
topic_facet |
Environmental sciences GE1-350 |
description |
Background: Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations. Objective: We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada). Methods: A complete set of data was obtained for 315 Inuit ≥ 18 years who participated in the “Santé Québec” health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP ≥ 140 mm Hg, diastolic BP ≥ 90 mm Hg or anti-hypertensive medication) were analyzed using multiple logistic regressions. Results: Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n−3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT), β-hexachlorocyclohexane (HCH) and oxychlordane. Conclusions: Some PCB congeners were associated with higher risk of hypertension in this highly exposed ... |
format |
Article in Journal/Newspaper |
author |
Beatriz Valera Pierre Ayotte Paul Poirier Éric Dewailly |
author_facet |
Beatriz Valera Pierre Ayotte Paul Poirier Éric Dewailly |
author_sort |
Beatriz Valera |
title |
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
title_short |
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
title_full |
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
title_fullStr |
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
title_full_unstemmed |
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik |
title_sort |
associations between plasma persistent organic pollutant levels and blood pressure in inuit adults from nunavik |
publisher |
Elsevier |
publishDate |
2013 |
url |
https://doi.org/10.1016/j.envint.2013.06.019 https://doaj.org/article/ef62af78509a4e3c82526c4b37e519cd |
geographic |
Arctic Canada Nunavik |
geographic_facet |
Arctic Canada Nunavik |
genre |
Arctic inuit Nunavik |
genre_facet |
Arctic inuit Nunavik |
op_source |
Environment International, Vol 59, Iss , Pp 282-289 (2013) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S0160412013001372 https://doaj.org/toc/0160-4120 0160-4120 doi:10.1016/j.envint.2013.06.019 https://doaj.org/article/ef62af78509a4e3c82526c4b37e519cd |
op_doi |
https://doi.org/10.1016/j.envint.2013.06.019 |
container_title |
Environment International |
container_volume |
59 |
container_start_page |
282 |
op_container_end_page |
289 |
_version_ |
1766342677667774464 |