Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers...
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ftdoajarticles:oai:doaj.org/article:ef39283b09ee495c8def0422be5602e6 2023-05-15T15:01:32+02:00 Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice Erica de Souza Fernandes Virgínia Maria de Barros Lorena Iana Rafaela Fernandes Sales Mônica Camelo Pessoa de Azevedo Albuquerque Yara de Miranda Gomes Vlaudia Maria Assis Costa Valdênia Maria Oliveira de Souza https://doi.org/10.1590/0037-8682-0338-2016 https://doaj.org/article/ef39283b09ee495c8def0422be5602e6 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400546&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0338-2016 https://doaj.org/article/ef39283b09ee495c8def0422be5602e6 Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 4, Pp 546-549 Maternal schistosomiasis Adult offspring Immunomodulation Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0338-2016 2022-12-31T02:55:15Z Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 51 4 546 549 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Maternal schistosomiasis Adult offspring Immunomodulation Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Maternal schistosomiasis Adult offspring Immunomodulation Arctic medicine. Tropical medicine RC955-962 Erica de Souza Fernandes Virgínia Maria de Barros Lorena Iana Rafaela Fernandes Sales Mônica Camelo Pessoa de Azevedo Albuquerque Yara de Miranda Gomes Vlaudia Maria Assis Costa Valdênia Maria Oliveira de Souza Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
topic_facet |
Maternal schistosomiasis Adult offspring Immunomodulation Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined. |
format |
Article in Journal/Newspaper |
author |
Erica de Souza Fernandes Virgínia Maria de Barros Lorena Iana Rafaela Fernandes Sales Mônica Camelo Pessoa de Azevedo Albuquerque Yara de Miranda Gomes Vlaudia Maria Assis Costa Valdênia Maria Oliveira de Souza |
author_facet |
Erica de Souza Fernandes Virgínia Maria de Barros Lorena Iana Rafaela Fernandes Sales Mônica Camelo Pessoa de Azevedo Albuquerque Yara de Miranda Gomes Vlaudia Maria Assis Costa Valdênia Maria Oliveira de Souza |
author_sort |
Erica de Souza Fernandes |
title |
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
title_short |
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
title_full |
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
title_fullStr |
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
title_full_unstemmed |
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
title_sort |
maternal schistosomiasis: il-2, il-10 and regulatory t lymphocytes to unrelated antigen in adult offspring mice |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0338-2016 https://doaj.org/article/ef39283b09ee495c8def0422be5602e6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 4, Pp 546-549 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000400546&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0338-2016 https://doaj.org/article/ef39283b09ee495c8def0422be5602e6 |
op_doi |
https://doi.org/10.1590/0037-8682-0338-2016 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
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51 |
container_issue |
4 |
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546 |
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549 |
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