A fatal case series of Rocky Mountain spotted fever in Sonora, México
Introduction: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. Objective: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. M...
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ftdoajarticles:oai:doaj.org/article:ef281cec39c840ceb0220cfde3ecb6b9 2023-05-15T15:11:18+02:00 A fatal case series of Rocky Mountain spotted fever in Sonora, México Jesús Delgado-De la Mora Jesús David Licona-Enríquez Marcia Leyva-Gastélum David Delgado-De la Mora Adela Rascón-Alcantar Gerardo Álvarez-Hernández 2018-03-01T00:00:00Z https://doi.org/10.7705/biomedica.v38i0.3507 https://doaj.org/article/ef281cec39c840ceb0220cfde3ecb6b9 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3507 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i0.3507 https://doaj.org/article/ef281cec39c840ceb0220cfde3ecb6b9 Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 1, Pp 69-76 (2018) Rickettsia rickettsii ticks Rocky Mountain spotted fever/mortality doxycycline México Medicine R Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.7705/biomedica.v38i0.3507 2022-12-31T02:12:20Z Introduction: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. Objective: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. Materials and methods: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence. Clinical and laboratory characteristics were compared stratifying subjects into two groups: pediatric and adult. Results: There were no differences in clinical characteristics between groups; petechial rash was the most frequent sign (96%), followed by headache (70%) and myalgia (67%). Although that doxycycline was administered before the fifth day from the onset of symptoms, death occurred in 55% of patients. In clinical laboratory, thrombocytopenia, and biomarkers of liver acute failure and acute kidney failure were the most frequent. Conclusion: Rocky Mountain spotted fever remains as one of the most lethal infectious diseases, which may be related not only to the lack of diagnostic suspicion and delayed administration of doxycycline, but to genotypic characteristics of Rickettsia rickettsii that may play a role in the variability of the fatality rate that has been reported in other geographical regions where the disease is endemic. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 38 1 69 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
Rickettsia rickettsii ticks Rocky Mountain spotted fever/mortality doxycycline México Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Rickettsia rickettsii ticks Rocky Mountain spotted fever/mortality doxycycline México Medicine R Arctic medicine. Tropical medicine RC955-962 Jesús Delgado-De la Mora Jesús David Licona-Enríquez Marcia Leyva-Gastélum David Delgado-De la Mora Adela Rascón-Alcantar Gerardo Álvarez-Hernández A fatal case series of Rocky Mountain spotted fever in Sonora, México |
topic_facet |
Rickettsia rickettsii ticks Rocky Mountain spotted fever/mortality doxycycline México Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. Objective: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. Materials and methods: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence. Clinical and laboratory characteristics were compared stratifying subjects into two groups: pediatric and adult. Results: There were no differences in clinical characteristics between groups; petechial rash was the most frequent sign (96%), followed by headache (70%) and myalgia (67%). Although that doxycycline was administered before the fifth day from the onset of symptoms, death occurred in 55% of patients. In clinical laboratory, thrombocytopenia, and biomarkers of liver acute failure and acute kidney failure were the most frequent. Conclusion: Rocky Mountain spotted fever remains as one of the most lethal infectious diseases, which may be related not only to the lack of diagnostic suspicion and delayed administration of doxycycline, but to genotypic characteristics of Rickettsia rickettsii that may play a role in the variability of the fatality rate that has been reported in other geographical regions where the disease is endemic. |
format |
Article in Journal/Newspaper |
author |
Jesús Delgado-De la Mora Jesús David Licona-Enríquez Marcia Leyva-Gastélum David Delgado-De la Mora Adela Rascón-Alcantar Gerardo Álvarez-Hernández |
author_facet |
Jesús Delgado-De la Mora Jesús David Licona-Enríquez Marcia Leyva-Gastélum David Delgado-De la Mora Adela Rascón-Alcantar Gerardo Álvarez-Hernández |
author_sort |
Jesús Delgado-De la Mora |
title |
A fatal case series of Rocky Mountain spotted fever in Sonora, México |
title_short |
A fatal case series of Rocky Mountain spotted fever in Sonora, México |
title_full |
A fatal case series of Rocky Mountain spotted fever in Sonora, México |
title_fullStr |
A fatal case series of Rocky Mountain spotted fever in Sonora, México |
title_full_unstemmed |
A fatal case series of Rocky Mountain spotted fever in Sonora, México |
title_sort |
fatal case series of rocky mountain spotted fever in sonora, méxico |
publisher |
Instituto Nacional de Salud |
publishDate |
2018 |
url |
https://doi.org/10.7705/biomedica.v38i0.3507 https://doaj.org/article/ef281cec39c840ceb0220cfde3ecb6b9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 1, Pp 69-76 (2018) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3507 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i0.3507 https://doaj.org/article/ef281cec39c840ceb0220cfde3ecb6b9 |
op_doi |
https://doi.org/10.7705/biomedica.v38i0.3507 |
container_title |
Biomédica |
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38 |
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1 |
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69 |
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1766342184848588800 |