Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model
Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam. (M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral obesity. Methods: M. olei...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:eef4b323dff24e429ce4d4ea019c34ab 2023-05-15T15:10:56+02:00 Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model Fateheya Mohamed Metwally Hend Mohamed Rashad Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla 2017-03-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.12.007 https://doaj.org/article/eef4b323dff24e429ce4d4ea019c34ab EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116305238 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.007 https://doaj.org/article/eef4b323dff24e429ce4d4ea019c34ab Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 214-221 (2017) Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.12.007 2022-12-31T11:13:31Z Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam. (M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral obesity. Methods: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the mRNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real time-PCR. Results: The results showed that M. oleifera extract down-regulated mRNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ones. Conclusions: It is reasonable to assume that the anti-obesity, anti-atherogenic and anti-diabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 3 214 221 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Fateheya Mohamed Metwally Hend Mohamed Rashad Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
topic_facet |
Moringa oleifera Lam Visceral adipose tissue Adipokines Gene expression Rats Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To elucidate the molecular mechanisms of the potent anti-obesity effect of Moringa oleifera Lam. (M. oleifera) ethanolic extract and to clarify the link between these mechanisms and the associated metabolic and vascular risks in the experimental model of visceral obesity. Methods: M. oleifera ethanolic extract was orally administered at 600 mg/kg body weight in obese female rats daily for 12 weeks. At the end of treatment, body weight was determined, and the atherogenic index, coronary artery index, glucose level, insulin resistance status, liver and kidney functions were assessed. Also, the mRNA of leptin, adiponectin and resistin in visceral adipose tissue was determined by quantitative real time-PCR. Results: The results showed that M. oleifera extract down-regulated mRNA expression of leptin and resistin, while it up-regulated adiponectin gene expression in obese rats relative to untreated obese control counterparts. This amelioration of genes expression was paralleled by a reduction in body weight and improvement of the atherogenic index and coronary artery index, as well as glucose level and insulin resistance value without adverse effects on liver or kidney functions, versus the untreated obese control ones. Conclusions: It is reasonable to assume that the anti-obesity, anti-atherogenic and anti-diabetic properties of M. oleifera are mechanistically achieved via working directly on the adipokines of the visceral adipose tissue. Therefore, M. oleifera may be a good therapeutic candidate for the symptoms of metabolic syndrome. |
format |
Article in Journal/Newspaper |
author |
Fateheya Mohamed Metwally Hend Mohamed Rashad Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla |
author_facet |
Fateheya Mohamed Metwally Hend Mohamed Rashad Hanaa Hamdy Ahmed Asmaa Ahmed Mahmoud Ehab Ragaa Abdol Raouf Aboelfetoh Mohamed Abdalla |
author_sort |
Fateheya Mohamed Metwally |
title |
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
title_short |
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
title_full |
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
title_fullStr |
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
title_full_unstemmed |
Molecular mechanisms of the anti-obesity potential effect of Moringa oleifera in the experimental model |
title_sort |
molecular mechanisms of the anti-obesity potential effect of moringa oleifera in the experimental model |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2016.12.007 https://doaj.org/article/eef4b323dff24e429ce4d4ea019c34ab |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 214-221 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116305238 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.007 https://doaj.org/article/eef4b323dff24e429ce4d4ea019c34ab |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.12.007 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
3 |
container_start_page |
214 |
op_container_end_page |
221 |
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1766341859453435904 |