Origin and evolution of dengue virus type 3 in Brazil.
The incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns, there have been very few studies of the molecular epidemiology and time-scale of t...
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ftdoajarticles:oai:doaj.org/article:eeb9c08f8fe2442db65e1ea2bd8b6dff 2023-05-15T15:14:20+02:00 Origin and evolution of dengue virus type 3 in Brazil. Josélio Maria Galvão de Araújo Gonzalo Bello Hector Romero Rita Maria Ribeiro Nogueira 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001784 https://doaj.org/article/eeb9c08f8fe2442db65e1ea2bd8b6dff EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3435237?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001784 1935-2727 1935-2735 https://doaj.org/article/eeb9c08f8fe2442db65e1ea2bd8b6dff PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1784 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001784 2022-12-31T01:46:23Z The incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns, there have been very few studies of the molecular epidemiology and time-scale of this DENV lineage in Brazil. In this study, we investigated the origin and dispersion dynamics of DENV-3 genotype III in Brazil by examining a large number (n=107) of E gene sequences sampled between 2001 and 2009 from diverse Brazilian regions. These Brazilian sequences were combined with 457 DENV-3 genotype III E gene sequences from 29 countries around the world. Our phylogenetic analysis reveals that there have been at least four introductions of the DENV-3 genotype III in Brazil, as signified by the presence of four phylogenetically distinct lineages. Three lineages (BR-I, BR-II, and BR-III) were probably imported from the Lesser Antilles (Caribbean), while the fourth one (BR-IV) was probably introduced from Colombia or Venezuela. While lineages BR-I and BR-II succeeded in getting established and disseminated in Brazil and other countries from the Southern Cone, lineages BR-III and BR-IV were only detected in one single individual each from the North region. The phylogeographic analysis indicates that DENV-3 lineages BR-I and BR-II were most likely introduced into Brazil through the Southeast and North regions around 1999 (95% HPD: 1998-2000) and 2001 (95% HPD: 2000-2002), respectively. These findings show that importation of DENV-3 lineages from the Caribbean islands into Brazil seems to be relatively frequent. Our study further suggests that the North and Southeast Brazilian regions were the most important hubs of introduction and spread of DENV-3 lineages and deserve an intense epidemiological surveillance. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 9 e1784 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Josélio Maria Galvão de Araújo Gonzalo Bello Hector Romero Rita Maria Ribeiro Nogueira Origin and evolution of dengue virus type 3 in Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns, there have been very few studies of the molecular epidemiology and time-scale of this DENV lineage in Brazil. In this study, we investigated the origin and dispersion dynamics of DENV-3 genotype III in Brazil by examining a large number (n=107) of E gene sequences sampled between 2001 and 2009 from diverse Brazilian regions. These Brazilian sequences were combined with 457 DENV-3 genotype III E gene sequences from 29 countries around the world. Our phylogenetic analysis reveals that there have been at least four introductions of the DENV-3 genotype III in Brazil, as signified by the presence of four phylogenetically distinct lineages. Three lineages (BR-I, BR-II, and BR-III) were probably imported from the Lesser Antilles (Caribbean), while the fourth one (BR-IV) was probably introduced from Colombia or Venezuela. While lineages BR-I and BR-II succeeded in getting established and disseminated in Brazil and other countries from the Southern Cone, lineages BR-III and BR-IV were only detected in one single individual each from the North region. The phylogeographic analysis indicates that DENV-3 lineages BR-I and BR-II were most likely introduced into Brazil through the Southeast and North regions around 1999 (95% HPD: 1998-2000) and 2001 (95% HPD: 2000-2002), respectively. These findings show that importation of DENV-3 lineages from the Caribbean islands into Brazil seems to be relatively frequent. Our study further suggests that the North and Southeast Brazilian regions were the most important hubs of introduction and spread of DENV-3 lineages and deserve an intense epidemiological surveillance. |
format |
Article in Journal/Newspaper |
author |
Josélio Maria Galvão de Araújo Gonzalo Bello Hector Romero Rita Maria Ribeiro Nogueira |
author_facet |
Josélio Maria Galvão de Araújo Gonzalo Bello Hector Romero Rita Maria Ribeiro Nogueira |
author_sort |
Josélio Maria Galvão de Araújo |
title |
Origin and evolution of dengue virus type 3 in Brazil. |
title_short |
Origin and evolution of dengue virus type 3 in Brazil. |
title_full |
Origin and evolution of dengue virus type 3 in Brazil. |
title_fullStr |
Origin and evolution of dengue virus type 3 in Brazil. |
title_full_unstemmed |
Origin and evolution of dengue virus type 3 in Brazil. |
title_sort |
origin and evolution of dengue virus type 3 in brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001784 https://doaj.org/article/eeb9c08f8fe2442db65e1ea2bd8b6dff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1784 (2012) |
op_relation |
http://europepmc.org/articles/PMC3435237?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001784 1935-2727 1935-2735 https://doaj.org/article/eeb9c08f8fe2442db65e1ea2bd8b6dff |
op_doi |
https://doi.org/10.1371/journal.pntd.0001784 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
6 |
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9 |
container_start_page |
e1784 |
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