Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine.
Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatme...
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ftdoajarticles:oai:doaj.org/article:eeb616478f0b4a30941c4fb365f20f6c 2023-05-15T15:03:17+02:00 Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. Shi-Hsia Hwa Yock Ann Lee Joseph N Brewoo Charalambos D Partidos Jorge E Osorio Joseph D Santangelo 2013-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002538 https://doaj.org/article/eeb616478f0b4a30941c4fb365f20f6c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3820736?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002538 https://doaj.org/article/eeb616478f0b4a30941c4fb365f20f6c PLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2538 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002538 2022-12-31T12:21:00Z Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies against HFMD is of growing importance. We report the immunogenic and safety profile of inactivated, purified EV71 preparations formulated with aluminum hydroxide adjuvant in preclinical studies in mice and rabbits. In mice, the candidate vaccine formulations elicited high neutralizing antibody responses. A toxicology study of the vaccine formulations planned for human use performed in rabbits showed no vaccine-related pathological changes and all animals remained healthy. Based on these preclinical studies, Phase 1 clinical testing of the EV71 inactivated vaccine was initiated. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Pacific PLoS Neglected Tropical Diseases 7 11 e2538 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shi-Hsia Hwa Yock Ann Lee Joseph N Brewoo Charalambos D Partidos Jorge E Osorio Joseph D Santangelo Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies against HFMD is of growing importance. We report the immunogenic and safety profile of inactivated, purified EV71 preparations formulated with aluminum hydroxide adjuvant in preclinical studies in mice and rabbits. In mice, the candidate vaccine formulations elicited high neutralizing antibody responses. A toxicology study of the vaccine formulations planned for human use performed in rabbits showed no vaccine-related pathological changes and all animals remained healthy. Based on these preclinical studies, Phase 1 clinical testing of the EV71 inactivated vaccine was initiated. |
format |
Article in Journal/Newspaper |
author |
Shi-Hsia Hwa Yock Ann Lee Joseph N Brewoo Charalambos D Partidos Jorge E Osorio Joseph D Santangelo |
author_facet |
Shi-Hsia Hwa Yock Ann Lee Joseph N Brewoo Charalambos D Partidos Jorge E Osorio Joseph D Santangelo |
author_sort |
Shi-Hsia Hwa |
title |
Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
title_short |
Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
title_full |
Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
title_fullStr |
Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
title_full_unstemmed |
Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
title_sort |
preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002538 https://doaj.org/article/eeb616478f0b4a30941c4fb365f20f6c |
geographic |
Arctic Pacific |
geographic_facet |
Arctic Pacific |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2538 (2013) |
op_relation |
http://europepmc.org/articles/PMC3820736?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002538 https://doaj.org/article/eeb616478f0b4a30941c4fb365f20f6c |
op_doi |
https://doi.org/10.1371/journal.pntd.0002538 |
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PLoS Neglected Tropical Diseases |
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7 |
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11 |
container_start_page |
e2538 |
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1766335154798723072 |