Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations.
INTRODUCTION:The human malaria parasite, Plasmodium vivax, is proving more difficult to control and eliminate than Plasmodium falciparum in areas of co-transmission. Comparisons of the genetic structure of sympatric parasite populations may provide insight into the mechanisms underlying the resilien...
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ftdoajarticles:oai:doaj.org/article:ee93086f8a6945bca0f0af92db3a918a 2023-05-15T15:15:26+02:00 Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. Charlie Jennison Alicia Arnott Natacha Tessier Livingstone Tavul Cristian Koepfli Ingrid Felger Peter M Siba John C Reeder Melanie Bahlo Ivo Mueller Alyssa E Barry 2015-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003634 https://doaj.org/article/ee93086f8a6945bca0f0af92db3a918a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4398418?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003634 https://doaj.org/article/ee93086f8a6945bca0f0af92db3a918a PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003634 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003634 2022-12-31T12:25:19Z INTRODUCTION:The human malaria parasite, Plasmodium vivax, is proving more difficult to control and eliminate than Plasmodium falciparum in areas of co-transmission. Comparisons of the genetic structure of sympatric parasite populations may provide insight into the mechanisms underlying the resilience of P. vivax and can help guide malaria control programs. METHODOLOGY/PRINCIPLE FINDINGS:P. vivax isolates representing the parasite populations of four areas on the north coast of Papua New Guinea (PNG) were genotyped using microsatellite markers and compared with previously published microsatellite data from sympatric P. falciparum isolates. The genetic diversity of P. vivax (He = 0.83-0.85) was higher than that of P. falciparum (He = 0.64-0.77) in all four populations. Moderate levels of genetic differentiation were found between P. falciparum populations, even over relatively short distances (less than 50 km), with 21-28% private alleles and clear geospatial genetic clustering. Conversely, very low population differentiation was found between P. vivax catchments, with less than 5% private alleles and no genetic clustering observed. In addition, the effective population size of P. vivax (30353; 13043-69142) was larger than that of P. falciparum (18871; 8109-42986). CONCLUSIONS/SIGNIFICANCE:Despite comparably high prevalence, P. vivax had higher diversity and a panmictic population structure compared to sympatric P. falciparum populations, which were fragmented into subpopulations. The results suggest that in comparison to P. falciparum, P. vivax has had a long-term large effective population size, consistent with more intense and stable transmission, and limited impact of past control and elimination efforts. This underlines suggestions that more intensive and sustained interventions will be needed to control and eventually eliminate P. vivax. This research clearly demonstrates how population genetic analyses can reveal deeper insight into transmission patterns than traditional surveillance methods. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 4 e0003634 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Charlie Jennison Alicia Arnott Natacha Tessier Livingstone Tavul Cristian Koepfli Ingrid Felger Peter M Siba John C Reeder Melanie Bahlo Ivo Mueller Alyssa E Barry Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:The human malaria parasite, Plasmodium vivax, is proving more difficult to control and eliminate than Plasmodium falciparum in areas of co-transmission. Comparisons of the genetic structure of sympatric parasite populations may provide insight into the mechanisms underlying the resilience of P. vivax and can help guide malaria control programs. METHODOLOGY/PRINCIPLE FINDINGS:P. vivax isolates representing the parasite populations of four areas on the north coast of Papua New Guinea (PNG) were genotyped using microsatellite markers and compared with previously published microsatellite data from sympatric P. falciparum isolates. The genetic diversity of P. vivax (He = 0.83-0.85) was higher than that of P. falciparum (He = 0.64-0.77) in all four populations. Moderate levels of genetic differentiation were found between P. falciparum populations, even over relatively short distances (less than 50 km), with 21-28% private alleles and clear geospatial genetic clustering. Conversely, very low population differentiation was found between P. vivax catchments, with less than 5% private alleles and no genetic clustering observed. In addition, the effective population size of P. vivax (30353; 13043-69142) was larger than that of P. falciparum (18871; 8109-42986). CONCLUSIONS/SIGNIFICANCE:Despite comparably high prevalence, P. vivax had higher diversity and a panmictic population structure compared to sympatric P. falciparum populations, which were fragmented into subpopulations. The results suggest that in comparison to P. falciparum, P. vivax has had a long-term large effective population size, consistent with more intense and stable transmission, and limited impact of past control and elimination efforts. This underlines suggestions that more intensive and sustained interventions will be needed to control and eventually eliminate P. vivax. This research clearly demonstrates how population genetic analyses can reveal deeper insight into transmission patterns than traditional surveillance methods. |
format |
Article in Journal/Newspaper |
author |
Charlie Jennison Alicia Arnott Natacha Tessier Livingstone Tavul Cristian Koepfli Ingrid Felger Peter M Siba John C Reeder Melanie Bahlo Ivo Mueller Alyssa E Barry |
author_facet |
Charlie Jennison Alicia Arnott Natacha Tessier Livingstone Tavul Cristian Koepfli Ingrid Felger Peter M Siba John C Reeder Melanie Bahlo Ivo Mueller Alyssa E Barry |
author_sort |
Charlie Jennison |
title |
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
title_short |
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
title_full |
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
title_fullStr |
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
title_full_unstemmed |
Plasmodium vivax populations are more genetically diverse and less structured than sympatric Plasmodium falciparum populations. |
title_sort |
plasmodium vivax populations are more genetically diverse and less structured than sympatric plasmodium falciparum populations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003634 https://doaj.org/article/ee93086f8a6945bca0f0af92db3a918a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003634 (2015) |
op_relation |
http://europepmc.org/articles/PMC4398418?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003634 https://doaj.org/article/ee93086f8a6945bca0f0af92db3a918a |
op_doi |
https://doi.org/10.1371/journal.pntd.0003634 |
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PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
4 |
container_start_page |
e0003634 |
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1766345799471464448 |