Variation in response of Schistosoma mansoni strains to schistosomicides

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Luiz Cândido de Souza Dias, John I. Bruce, Gerald C. Coles
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1988
• Subjects: Schistosoma mansoni; Experimental chemotherapy; resistance to drugs; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651988000200005; https://doaj.org/article/ee36ced695714a00aae30eb1f9879eaf

The BH strain of Schistosoma mansoni was found to be highly susceptible, to hy cant hone (1 x 80 mg/kg), oxamniquine (1 x 100 mg/kg) niridazole (5 x 100 mg/kg), praziquantel (1 x 100 mg/kg), oltipraz (5 x 125 mg/kg) and amoscanate (1 x 300 mg/kg) and is therefore a good reference strain for chemotherapeutic trials. By contrast, the MPR-1 strain was shown to have developed resistance to oxamniquine without ever having been dosed with oxamniquine. Other oxamniquine/hycanthone resistant strains were shown to have maintained their resistance and a strain believed to be partially resistant to oltipraz was evaluated.