Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats
Objective: To assess the effects of Falcaria vulgaris (F. vulgaris) as an antioxidant on damage to kidney of diabetic rats. Methods: Diabetic rats were established via streptozotocin (60 mg/kg). Various doses of F. vulgaris extracts (50, 100 and 150 mg/kg) and streptozotocin + F. vulgaris extracts w...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2019
|
Subjects: | |
Online Access: | https://doi.org/10.4103/2221-1691.256728 https://doaj.org/article/ee0ed976cecc4cc3a7d8172e8c8b4a52 |
id |
ftdoajarticles:oai:doaj.org/article:ee0ed976cecc4cc3a7d8172e8c8b4a52 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ee0ed976cecc4cc3a7d8172e8c8b4a52 2023-05-15T15:06:56+02:00 Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats Jalili Cyrus Roshankhah Shiva Salahshoor Mohammad Reza 2019-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.256728 https://doaj.org/article/ee0ed976cecc4cc3a7d8172e8c8b4a52 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=4;spage=150;epage=157;aulast=Cyrus https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.256728 https://doaj.org/article/ee0ed976cecc4cc3a7d8172e8c8b4a52 Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 4, Pp 150-157 (2019) antioxidant diabetes falcaria vulgaris kidney Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.4103/2221-1691.256728 2022-12-31T00:33:51Z Objective: To assess the effects of Falcaria vulgaris (F. vulgaris) as an antioxidant on damage to kidney of diabetic rats. Methods: Diabetic rats were established via streptozotocin (60 mg/kg). Various doses of F. vulgaris extracts (50, 100 and 150 mg/kg) and streptozotocin + F. vulgaris extracts were administered via intraperitoneal (i.p) injection to 48 rats (n=8 per group) for 28 d. Subsequently, ferric ion reducing antioxidant power (FRAP) of renal tissue, thiobarbituric acid reactive species, blood glucose concentrations, insulin, nitrite oxide, the weight of animals, glomeruli characteristics and kidney function were evaluated. Results: Compared with the control rats, diabetic rats showed significant increase in malondialdehyde, blood urea nitrogen, creatinine, blood glucose, nitrite oxide contents in renal tissues, and glomerular diameter. Furthermore, tissue FRAP level, body weight, number of glomeruli and plasma insulin were markedly reduced in diabetic rats when compared with the control group (P < 0.05). However, in all F. vulgaris and F. vulgaris + streptozotocin groups, malondialdehyde level, blood urea nitrogen, creatinine, glomerular diameter, nitrite oxide, and glucose levels were decreased significantly; meanwhile, tissue FRAP level, body weight, glomeruli number and insulin serum level were increased, compared to the control diabetic group (P < 0.05). Conclusions: F. vulgaris extract alleviates renal damage in diabetic rats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 9 4 150 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antioxidant diabetes falcaria vulgaris kidney Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
antioxidant diabetes falcaria vulgaris kidney Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Jalili Cyrus Roshankhah Shiva Salahshoor Mohammad Reza Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
topic_facet |
antioxidant diabetes falcaria vulgaris kidney Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess the effects of Falcaria vulgaris (F. vulgaris) as an antioxidant on damage to kidney of diabetic rats. Methods: Diabetic rats were established via streptozotocin (60 mg/kg). Various doses of F. vulgaris extracts (50, 100 and 150 mg/kg) and streptozotocin + F. vulgaris extracts were administered via intraperitoneal (i.p) injection to 48 rats (n=8 per group) for 28 d. Subsequently, ferric ion reducing antioxidant power (FRAP) of renal tissue, thiobarbituric acid reactive species, blood glucose concentrations, insulin, nitrite oxide, the weight of animals, glomeruli characteristics and kidney function were evaluated. Results: Compared with the control rats, diabetic rats showed significant increase in malondialdehyde, blood urea nitrogen, creatinine, blood glucose, nitrite oxide contents in renal tissues, and glomerular diameter. Furthermore, tissue FRAP level, body weight, number of glomeruli and plasma insulin were markedly reduced in diabetic rats when compared with the control group (P < 0.05). However, in all F. vulgaris and F. vulgaris + streptozotocin groups, malondialdehyde level, blood urea nitrogen, creatinine, glomerular diameter, nitrite oxide, and glucose levels were decreased significantly; meanwhile, tissue FRAP level, body weight, glomeruli number and insulin serum level were increased, compared to the control diabetic group (P < 0.05). Conclusions: F. vulgaris extract alleviates renal damage in diabetic rats. |
format |
Article in Journal/Newspaper |
author |
Jalili Cyrus Roshankhah Shiva Salahshoor Mohammad Reza |
author_facet |
Jalili Cyrus Roshankhah Shiva Salahshoor Mohammad Reza |
author_sort |
Jalili Cyrus |
title |
Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
title_short |
Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
title_full |
Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
title_fullStr |
Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
title_full_unstemmed |
Falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
title_sort |
falcaria vulgaris extract attenuates diabetes–induced kidney injury in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/2221-1691.256728 https://doaj.org/article/ee0ed976cecc4cc3a7d8172e8c8b4a52 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 4, Pp 150-157 (2019) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=4;spage=150;epage=157;aulast=Cyrus https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.256728 https://doaj.org/article/ee0ed976cecc4cc3a7d8172e8c8b4a52 |
op_doi |
https://doi.org/10.4103/2221-1691.256728 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
9 |
container_issue |
4 |
container_start_page |
150 |
_version_ |
1766338525568958464 |