Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina.
Background Strongyloidiasis and Chagas disease are endemic in northern Argentina. In this study we evaluate the association between S. stercoralis and T. cruzi infections in villages with diverse prevalence levels for these parasites. Further understanding in the relationship between these Neglected...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:ee0ded55b2024ce3891f3d550dd44022 2023-05-15T15:14:13+02:00 Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. Pedro E Fleitas Noelia Floridia-Yapur Elvia E Nieves Adriana Echazu Paola A Vargas Nicolás R Caro Ramiro Aveldaño Walter Lopez Mariana Fernandez Favio Crudo Rubén O Cimino Alejandro J Krolewiecki 2022-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010179 https://doaj.org/article/ee0ded55b2024ce3891f3d550dd44022 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010179 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010179 https://doaj.org/article/ee0ded55b2024ce3891f3d550dd44022 PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010179 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010179 2022-12-31T12:59:45Z Background Strongyloidiasis and Chagas disease are endemic in northern Argentina. In this study we evaluate the association between S. stercoralis and T. cruzi infections in villages with diverse prevalence levels for these parasites. Further understanding in the relationship between these Neglected Tropical Diseases of South America is relevant for the design of integrated control measures as well as exploring potential biologic interactions. Methodology Community based cross-sectional studies were carried in different villages of the Chaco and Yungas regions in Argentina. Individuals were diagnosed by serology for S. stercoralis and T. cruzi. The association between S. stercoralis and T. cruzi, and between anemia and the two parasites was evaluated using two approaches: marginal (Ma) and multilevel regression (Mu). Results A total of 706 individuals from six villages of northern Argentina were included. A total of 37% were positive for S. stercoralis, 14% were positive for T. cruzi and 5% were positive for both. No association was found between infection with S. stercoralis and T. cruzi in any of the models, but we found a negative correlation between the prevalence of these species in the different villages (r = -0.91). Adults (> 15 years) presented association with S. stercoralis (Ma OR = 2.72; Mu OR = 2.84) and T. cruzi (Ma OR = 5.12; Mu OR = 5.48). Also, 12% and 2% of the variance of infection with S. stercoralis and T. cruzi, respectively, could be explained by differences among villages. On the other hand, anemia was associated with infection with S. stercoralis (Ma OR = 1.73; Mu OR = 1.78) and was more prevalent in adults (Ma OR = 2.59; Mu OR = 2.69). Conclusion We found that coinfection between S. stercoralis and T. cruzi is not more frequent than chance in endemic areas. However, the high prevalence for both parasites, raises the need for an integrated strategy for the control of STH and Chagas disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina Chaco ENVELOPE(-60.583,-60.583,-63.033,-63.033) PLOS Neglected Tropical Diseases 16 2 e0010179 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pedro E Fleitas Noelia Floridia-Yapur Elvia E Nieves Adriana Echazu Paola A Vargas Nicolás R Caro Ramiro Aveldaño Walter Lopez Mariana Fernandez Favio Crudo Rubén O Cimino Alejandro J Krolewiecki Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Strongyloidiasis and Chagas disease are endemic in northern Argentina. In this study we evaluate the association between S. stercoralis and T. cruzi infections in villages with diverse prevalence levels for these parasites. Further understanding in the relationship between these Neglected Tropical Diseases of South America is relevant for the design of integrated control measures as well as exploring potential biologic interactions. Methodology Community based cross-sectional studies were carried in different villages of the Chaco and Yungas regions in Argentina. Individuals were diagnosed by serology for S. stercoralis and T. cruzi. The association between S. stercoralis and T. cruzi, and between anemia and the two parasites was evaluated using two approaches: marginal (Ma) and multilevel regression (Mu). Results A total of 706 individuals from six villages of northern Argentina were included. A total of 37% were positive for S. stercoralis, 14% were positive for T. cruzi and 5% were positive for both. No association was found between infection with S. stercoralis and T. cruzi in any of the models, but we found a negative correlation between the prevalence of these species in the different villages (r = -0.91). Adults (> 15 years) presented association with S. stercoralis (Ma OR = 2.72; Mu OR = 2.84) and T. cruzi (Ma OR = 5.12; Mu OR = 5.48). Also, 12% and 2% of the variance of infection with S. stercoralis and T. cruzi, respectively, could be explained by differences among villages. On the other hand, anemia was associated with infection with S. stercoralis (Ma OR = 1.73; Mu OR = 1.78) and was more prevalent in adults (Ma OR = 2.59; Mu OR = 2.69). Conclusion We found that coinfection between S. stercoralis and T. cruzi is not more frequent than chance in endemic areas. However, the high prevalence for both parasites, raises the need for an integrated strategy for the control of STH and Chagas disease. |
format |
Article in Journal/Newspaper |
author |
Pedro E Fleitas Noelia Floridia-Yapur Elvia E Nieves Adriana Echazu Paola A Vargas Nicolás R Caro Ramiro Aveldaño Walter Lopez Mariana Fernandez Favio Crudo Rubén O Cimino Alejandro J Krolewiecki |
author_facet |
Pedro E Fleitas Noelia Floridia-Yapur Elvia E Nieves Adriana Echazu Paola A Vargas Nicolás R Caro Ramiro Aveldaño Walter Lopez Mariana Fernandez Favio Crudo Rubén O Cimino Alejandro J Krolewiecki |
author_sort |
Pedro E Fleitas |
title |
Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
title_short |
Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
title_full |
Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
title_fullStr |
Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
title_full_unstemmed |
Strongyloides stercoralis and Trypanosoma cruzi coinfections in a highly endemic area in Argentina. |
title_sort |
strongyloides stercoralis and trypanosoma cruzi coinfections in a highly endemic area in argentina. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010179 https://doaj.org/article/ee0ded55b2024ce3891f3d550dd44022 |
long_lat |
ENVELOPE(-60.583,-60.583,-63.033,-63.033) |
geographic |
Arctic Argentina Chaco |
geographic_facet |
Arctic Argentina Chaco |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010179 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010179 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010179 https://doaj.org/article/ee0ded55b2024ce3891f3d550dd44022 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010179 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
2 |
container_start_page |
e0010179 |
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1766344694088859648 |