High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil.
BACKGROUND:Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between...
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Online Access: | https://doi.org/10.1371/journal.pntd.0003691 https://doaj.org/article/edc32dd5b9fd43929b2e9c82d53d4087 |
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ftdoajarticles:oai:doaj.org/article:edc32dd5b9fd43929b2e9c82d53d4087 2023-05-15T15:13:05+02:00 High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. Larissa M Bandeira Silvia N O Uehara Marcel A Asato Gabriela S Aguena Cristiane M Maedo Nikolas H Benites Marco A M Puga Grazielli R Rezende Carolina M Finotti Gabriela A Cesar Tayana S O Tanaka Vivianne O L Castro Koko Otsuki Ana C P Vicente Carlos E Fernandes Ana R C Motta-Castro 2015-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003691 https://doaj.org/article/edc32dd5b9fd43929b2e9c82d53d4087 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4401538?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003691 https://doaj.org/article/edc32dd5b9fd43929b2e9c82d53d4087 PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003691 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003691 2022-12-31T08:53:24Z BACKGROUND:Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan. OBJECTIVE:This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV. STUDY DESIGN:A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing. RESULTS:The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese). CONCLUSION:The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 4 e0003691 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Larissa M Bandeira Silvia N O Uehara Marcel A Asato Gabriela S Aguena Cristiane M Maedo Nikolas H Benites Marco A M Puga Grazielli R Rezende Carolina M Finotti Gabriela A Cesar Tayana S O Tanaka Vivianne O L Castro Koko Otsuki Ana C P Vicente Carlos E Fernandes Ana R C Motta-Castro High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan. OBJECTIVE:This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV. STUDY DESIGN:A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing. RESULTS:The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese). CONCLUSION:The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil. |
format |
Article in Journal/Newspaper |
author |
Larissa M Bandeira Silvia N O Uehara Marcel A Asato Gabriela S Aguena Cristiane M Maedo Nikolas H Benites Marco A M Puga Grazielli R Rezende Carolina M Finotti Gabriela A Cesar Tayana S O Tanaka Vivianne O L Castro Koko Otsuki Ana C P Vicente Carlos E Fernandes Ana R C Motta-Castro |
author_facet |
Larissa M Bandeira Silvia N O Uehara Marcel A Asato Gabriela S Aguena Cristiane M Maedo Nikolas H Benites Marco A M Puga Grazielli R Rezende Carolina M Finotti Gabriela A Cesar Tayana S O Tanaka Vivianne O L Castro Koko Otsuki Ana C P Vicente Carlos E Fernandes Ana R C Motta-Castro |
author_sort |
Larissa M Bandeira |
title |
High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
title_short |
High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
title_full |
High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
title_fullStr |
High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
title_full_unstemmed |
High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil. |
title_sort |
high prevalence of htlv-1 infection among japanese immigrants in non-endemic area of brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003691 https://doaj.org/article/edc32dd5b9fd43929b2e9c82d53d4087 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003691 (2015) |
op_relation |
http://europepmc.org/articles/PMC4401538?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003691 https://doaj.org/article/edc32dd5b9fd43929b2e9c82d53d4087 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003691 |
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PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
4 |
container_start_page |
e0003691 |
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1766343686957826048 |