Aspects of the granulomatous reaction in the liver of mice infected and reinfected with two different geographical strains of Schistosoma mansoni

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Pedro Raso, Paulo Marcos Z. Coelho, Nivaldo H. Toppa, Rômulo T. Mello
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1994
• Subjects: Granuloma; Reação granulomatosa; Schistosoma mansoni; Cepas geográficas; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821994000400004; https://doaj.org/article/eda80b59d7394e23aabdbe7924e93b39

In this study, which was undertaken in relation to the histopathologic behavior of two different strains (LE-Belo Horizonte, MG and SJ - São José dos Campos, SP) in infections and reinfections (homologous or heterologous) with Schistosoma mansoni, the authors confirmed a more accentuated pathogenicity of the SJ strain. All the reinfections showed the presence of typical granulomas of the acute phase, when performed either with the same strain (homologous) or with a different strain (heterologous) of the parasite of the primo infection. The possible mechanisms responsible for reactivation of the immunopathologic response in reinfections are discussed.