Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China
Objective: To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China. Methods: This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with laboratory-confirmed dengue in a tertiary cent...
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ftdoajarticles:oai:doaj.org/article:eda6cb94b6564ccb8f5f11738d89cea6 2023-08-15T12:40:22+02:00 Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.377741 https://doaj.org/article/eda6cb94b6564ccb8f5f11738d89cea6 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=5;spage=204;epage=212;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.377741 https://doaj.org/article/eda6cb94b6564ccb8f5f11738d89cea6 Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 5, Pp 204-212 (2023) dengue severe dengue serum albumin hypoalbuminemia prediction Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.377741 2023-07-23T00:33:55Z Objective: To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China. Methods: This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in mainland China. Serum albumin levels were estimated and compared between patients with severe dengue and non-severe dengue. Additionally, the association between serum albumin levels and severe dengue was evaluated using a generalized linear model [relative risks (RR)]. Multivariate logistic regression analysis was performed to identify the potential predictors of severe dengue. Results: Overall, 1568 patients were included in this study. Of these patients, 34 (2.17%) developed severe dengue. The median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue (33 g/L vs. 37 g/L, P<0.001). After adjustment for age, sex, and comorbidities, hypoalbuminemia (RR 4.877, 95% CI 2.193-11.461, P<0.001) was found to be a predictor of severe dengue. Serum albumin levels (OR 1.303, 95% CI 1.161-1.462, P<0.001)] and age (OR 1.038, 95% CI 1.017-1.061, P<0.001) were significant risk factors for severe dengue. The area under the curve for serum albumin levels to distinguish severe dengue was 0.787. Conclusions: Lower serum albumin levels were significantly associated with disease severity in adult patients with dengue. Hypoalbuminemia on admission resulted in at least a four-fold increased risk of severe dengue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 16 5 204 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
dengue severe dengue serum albumin hypoalbuminemia prediction Arctic medicine. Tropical medicine RC955-962 |
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dengue severe dengue serum albumin hypoalbuminemia prediction Arctic medicine. Tropical medicine RC955-962 Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
topic_facet |
dengue severe dengue serum albumin hypoalbuminemia prediction Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China. Methods: This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in mainland China. Serum albumin levels were estimated and compared between patients with severe dengue and non-severe dengue. Additionally, the association between serum albumin levels and severe dengue was evaluated using a generalized linear model [relative risks (RR)]. Multivariate logistic regression analysis was performed to identify the potential predictors of severe dengue. Results: Overall, 1568 patients were included in this study. Of these patients, 34 (2.17%) developed severe dengue. The median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue (33 g/L vs. 37 g/L, P<0.001). After adjustment for age, sex, and comorbidities, hypoalbuminemia (RR 4.877, 95% CI 2.193-11.461, P<0.001) was found to be a predictor of severe dengue. Serum albumin levels (OR 1.303, 95% CI 1.161-1.462, P<0.001)] and age (OR 1.038, 95% CI 1.017-1.061, P<0.001) were significant risk factors for severe dengue. The area under the curve for serum albumin levels to distinguish severe dengue was 0.787. Conclusions: Lower serum albumin levels were significantly associated with disease severity in adult patients with dengue. Hypoalbuminemia on admission resulted in at least a four-fold increased risk of severe dengue. |
format |
Article in Journal/Newspaper |
author |
Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang |
author_facet |
Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang |
author_sort |
Changtai Wang |
title |
Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
title_short |
Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
title_full |
Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
title_fullStr |
Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
title_full_unstemmed |
Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in mainland China |
title_sort |
association between serum albumin levels and disease severity in adult patients with dengue: a 7-year retrospective cohort study in mainland china |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.377741 https://doaj.org/article/eda6cb94b6564ccb8f5f11738d89cea6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 5, Pp 204-212 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=5;spage=204;epage=212;aulast=Wang https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.377741 https://doaj.org/article/eda6cb94b6564ccb8f5f11738d89cea6 |
op_doi |
https://doi.org/10.4103/1995-7645.377741 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
5 |
container_start_page |
204 |
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1774293143106093056 |