Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial
The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be...
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Cambridge University Press
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ftdoajarticles:oai:doaj.org/article:ed930ca987ce421184b66fd422454125 2023-05-15T15:27:49+02:00 Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial Hanna Fjeldheim Dale Caroline Jensen Trygve Hausken Einar Lied Jan Gunnar Hatlebakk Ingeborg Brønstad Dag Arne Lihaug Hoff Gülen Arslan Lied 2018-01-01T00:00:00Z https://doi.org/10.1017/jns.2018.23 https://doaj.org/article/ed930ca987ce421184b66fd422454125 EN eng Cambridge University Press https://www.cambridge.org/core/product/identifier/S204867901800023X/type/journal_article https://doaj.org/toc/2048-6790 doi:10.1017/jns.2018.23 2048-6790 https://doaj.org/article/ed930ca987ce421184b66fd422454125 Journal of Nutritional Science, Vol 7 (2018) Marine protein hydrolysate Fish protein Marine peptides Glucose metabolism Nutrition. Foods and food supply TX341-641 Medicine R article 2018 ftdoajarticles https://doi.org/10.1017/jns.2018.23 2023-03-12T01:31:02Z The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod (Gadus morhua) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial (n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles Journal of Nutritional Science 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Marine protein hydrolysate Fish protein Marine peptides Glucose metabolism Nutrition. Foods and food supply TX341-641 Medicine R |
spellingShingle |
Marine protein hydrolysate Fish protein Marine peptides Glucose metabolism Nutrition. Foods and food supply TX341-641 Medicine R Hanna Fjeldheim Dale Caroline Jensen Trygve Hausken Einar Lied Jan Gunnar Hatlebakk Ingeborg Brønstad Dag Arne Lihaug Hoff Gülen Arslan Lied Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
topic_facet |
Marine protein hydrolysate Fish protein Marine peptides Glucose metabolism Nutrition. Foods and food supply TX341-641 Medicine R |
description |
The increased prevalence of lifestyle diseases, such as the metabolic syndrome and type 2 diabetes mellitus (T2DM), calls for more knowledge on dietary treatments targeting the specific metabolic pathways involved in these conditions. Several studies have shown a protein preload before a meal to be effective in lowering the postprandial glycaemic response in healthy individuals and patients with T2DM. The aim of the present study was to assess the effect of a marine protein hydrolysate (MPH) from Atlantic cod (Gadus morhua) on postprandial glucose metabolism in healthy, middle-aged to elderly subjects. This double-blind cross-over trial (n 41) included two study days with 4–7 d wash-out in between. The intervention consisted of 20 mg of MPH (or casein as control) per kg body weight given before a breakfast meal. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose, insulin and plasma glucagon-like peptide 1 (GLP-1) in 20 min intervals for 180 min. In a mixed-model regression analysis, no differences were observed between MPH and control for postprandial glucose concentration (mean difference: −0·04 (95 % CI –0·17, 0·09) mmol/l; P = 0·573) or GLP-1 concentration (mean difference between geometric means: 1·02 (95 % CI 0·99, 1·06) pmol/l; P = 0·250). The postprandial insulin concentration was significantly lower after MPH compared with control (mean difference between geometric means: 1·067 (95 % CI 1·01, 1·13) mIU/l; P = 0·032). Our findings demonstrate that a single dose of MPH before a breakfast meal reduces postprandial insulin secretion, without affecting blood glucose response or GLP-1 levels, in healthy individuals. Further studies with repeated dosing and in target groups with abnormal glucose control are warranted. |
format |
Article in Journal/Newspaper |
author |
Hanna Fjeldheim Dale Caroline Jensen Trygve Hausken Einar Lied Jan Gunnar Hatlebakk Ingeborg Brønstad Dag Arne Lihaug Hoff Gülen Arslan Lied |
author_facet |
Hanna Fjeldheim Dale Caroline Jensen Trygve Hausken Einar Lied Jan Gunnar Hatlebakk Ingeborg Brønstad Dag Arne Lihaug Hoff Gülen Arslan Lied |
author_sort |
Hanna Fjeldheim Dale |
title |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_short |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_full |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_fullStr |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_full_unstemmed |
Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
title_sort |
effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial |
publisher |
Cambridge University Press |
publishDate |
2018 |
url |
https://doi.org/10.1017/jns.2018.23 https://doaj.org/article/ed930ca987ce421184b66fd422454125 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
Journal of Nutritional Science, Vol 7 (2018) |
op_relation |
https://www.cambridge.org/core/product/identifier/S204867901800023X/type/journal_article https://doaj.org/toc/2048-6790 doi:10.1017/jns.2018.23 2048-6790 https://doaj.org/article/ed930ca987ce421184b66fd422454125 |
op_doi |
https://doi.org/10.1017/jns.2018.23 |
container_title |
Journal of Nutritional Science |
container_volume |
7 |
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1766358227138641920 |