Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination.
BACKGROUND: Appropriate diagnostics to monitor disease trends and assess the effectiveness and impact of interventions are essential for guiding treatment strategies at different thresholds of schistosomiasis transmission and for certifying elimination. Field validation of these assays is urgently n...
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Online Access: | https://doi.org/10.1371/journal.pntd.0001408 https://doaj.org/article/ed64ec5926d54a1fb87c13b6b93290be |
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ftdoajarticles:oai:doaj.org/article:ed64ec5926d54a1fb87c13b6b93290be 2023-05-15T15:15:23+02:00 Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. Xiao-Nong Zhou Jing Xu Hong-Gen Chen Tian-Ping Wang Xi-Bao Huang Dan-Dan Lin Qi-Zhi Wang Li Tang Jia-Gang Guo Xiao-Hua Wu Ting Feng Jia-Xu Chen Jian Guo Shao-Hong Chen Hao Li Zhong-Dao Wu Rosanna W Peeling 2011-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001408 https://doaj.org/article/ed64ec5926d54a1fb87c13b6b93290be EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3243709?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001408 https://doaj.org/article/ed64ec5926d54a1fb87c13b6b93290be PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1408 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001408 2022-12-31T12:39:58Z BACKGROUND: Appropriate diagnostics to monitor disease trends and assess the effectiveness and impact of interventions are essential for guiding treatment strategies at different thresholds of schistosomiasis transmission and for certifying elimination. Field validation of these assays is urgently needed before they can be adopted to support policy decisions of the national programme for control and elimination of schistosomiasis in P.R. China. We compared the efficacy and utility of different immunoassays in guiding control strategies and monitoring the endemic status of S. japonicum infections towards elimination. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was conducted in seven villages with different transmission intensities settings to assess the performance and utility of three immunoassays, e.g., an indirect hemagglutination assay (IHA_JX), an enzyme linked immunosorbent assay (ELISA_SZ), and a dot immunogold filtration assay (DIGFA_SH). 6,248 individuals aged 6-65 years old who gave consent and supplied their stool and blood samples were included for data analysis. Results showed that ELISA_SZ performed significantly higher sensitivity (95.45%, 95%CI: 92.94-97.97%) than IHA_JX (87.59%, 95%CI: 83.51-91.49%) and DIGFA_SH (79.55%, 95%CI: 74.68-84.41%), especially in subgroups with very low infection intensity. The specificity of ELISA_SZ, IHA_JX, DIGFA_SH in 6-9 year olds with occasional exposure was nearly 90%. DIGFA_SH performed the highest screening efficacy for patients among three assays with overall positive predicative value of 13.07% (95%CI: 11.42-14.72%). We found a positive correlation of antibody positive rate of IHA_JX with results of stool examination in age strata (r = 0.70, P<0.001). Seropositivity of IHA_JX in children aged 6-9 years old showed an excellent correlation with prevalence of schistosome infection in the seven communities (r = 0.77, P<0.05). CONCLUSIONS/SIGNIFICANCE: Studies suggest that ELISA_SZ could be used to guide selective chemotherapy in moderate or low ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 12 e1408 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Xiao-Nong Zhou Jing Xu Hong-Gen Chen Tian-Ping Wang Xi-Bao Huang Dan-Dan Lin Qi-Zhi Wang Li Tang Jia-Gang Guo Xiao-Hua Wu Ting Feng Jia-Xu Chen Jian Guo Shao-Hong Chen Hao Li Zhong-Dao Wu Rosanna W Peeling Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Appropriate diagnostics to monitor disease trends and assess the effectiveness and impact of interventions are essential for guiding treatment strategies at different thresholds of schistosomiasis transmission and for certifying elimination. Field validation of these assays is urgently needed before they can be adopted to support policy decisions of the national programme for control and elimination of schistosomiasis in P.R. China. We compared the efficacy and utility of different immunoassays in guiding control strategies and monitoring the endemic status of S. japonicum infections towards elimination. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional survey was conducted in seven villages with different transmission intensities settings to assess the performance and utility of three immunoassays, e.g., an indirect hemagglutination assay (IHA_JX), an enzyme linked immunosorbent assay (ELISA_SZ), and a dot immunogold filtration assay (DIGFA_SH). 6,248 individuals aged 6-65 years old who gave consent and supplied their stool and blood samples were included for data analysis. Results showed that ELISA_SZ performed significantly higher sensitivity (95.45%, 95%CI: 92.94-97.97%) than IHA_JX (87.59%, 95%CI: 83.51-91.49%) and DIGFA_SH (79.55%, 95%CI: 74.68-84.41%), especially in subgroups with very low infection intensity. The specificity of ELISA_SZ, IHA_JX, DIGFA_SH in 6-9 year olds with occasional exposure was nearly 90%. DIGFA_SH performed the highest screening efficacy for patients among three assays with overall positive predicative value of 13.07% (95%CI: 11.42-14.72%). We found a positive correlation of antibody positive rate of IHA_JX with results of stool examination in age strata (r = 0.70, P<0.001). Seropositivity of IHA_JX in children aged 6-9 years old showed an excellent correlation with prevalence of schistosome infection in the seven communities (r = 0.77, P<0.05). CONCLUSIONS/SIGNIFICANCE: Studies suggest that ELISA_SZ could be used to guide selective chemotherapy in moderate or low ... |
format |
Article in Journal/Newspaper |
author |
Xiao-Nong Zhou Jing Xu Hong-Gen Chen Tian-Ping Wang Xi-Bao Huang Dan-Dan Lin Qi-Zhi Wang Li Tang Jia-Gang Guo Xiao-Hua Wu Ting Feng Jia-Xu Chen Jian Guo Shao-Hong Chen Hao Li Zhong-Dao Wu Rosanna W Peeling |
author_facet |
Xiao-Nong Zhou Jing Xu Hong-Gen Chen Tian-Ping Wang Xi-Bao Huang Dan-Dan Lin Qi-Zhi Wang Li Tang Jia-Gang Guo Xiao-Hua Wu Ting Feng Jia-Xu Chen Jian Guo Shao-Hong Chen Hao Li Zhong-Dao Wu Rosanna W Peeling |
author_sort |
Xiao-Nong Zhou |
title |
Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
title_short |
Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
title_full |
Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
title_fullStr |
Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
title_full_unstemmed |
Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. |
title_sort |
tools to support policy decisions related to treatment strategies and surveillance of schistosomiasis japonica towards elimination. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001408 https://doaj.org/article/ed64ec5926d54a1fb87c13b6b93290be |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1408 (2011) |
op_relation |
http://europepmc.org/articles/PMC3243709?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001408 https://doaj.org/article/ed64ec5926d54a1fb87c13b6b93290be |
op_doi |
https://doi.org/10.1371/journal.pntd.0001408 |
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PLoS Neglected Tropical Diseases |
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5 |
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12 |
container_start_page |
e1408 |
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