The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group
Abstract Background Dengue virus (DENV) is a member of insect vector-borne viruses, and it causes dengue fever. Southeast Asia is the epi-center of dengue fever in the world. The characterization of the virus is essential to identify the transmission and evolution of DENV. Objectives In 2017, there...
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ftdoajarticles:oai:doaj.org/article:ed611bc94d0442ab84c1c86a5977edb1 2023-05-15T15:10:14+02:00 The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group Taichiro Takemura Co Thach Nguyen Ha Chau Pham Thuy Trang Nguyen Vu Mai Phuong Hoang Le Khanh Hang Nguyen Takeshi Nabeshima Thi Thu Thuy Nguyen Thi Quynh Mai Le Meng Ling Moi Kouichi Morita Futoshi Hasebe 2022-01-01T00:00:00Z https://doi.org/10.1186/s41182-021-00386-0 https://doaj.org/article/ed611bc94d0442ab84c1c86a5977edb1 EN eng BMC https://doi.org/10.1186/s41182-021-00386-0 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00386-0 1349-4147 https://doaj.org/article/ed611bc94d0442ab84c1c86a5977edb1 Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-5 (2022) Dengue virus Vietnam Viral genome Virus circulation Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1186/s41182-021-00386-0 2022-12-30T20:36:36Z Abstract Background Dengue virus (DENV) is a member of insect vector-borne viruses, and it causes dengue fever. Southeast Asia is the epi-center of dengue fever in the world. The characterization of the virus is essential to identify the transmission and evolution of DENV. Objectives In 2017, there was an outbreak of Dengue virus type 1 (DENV1) in northern Vietnam and the neighboring countries. To identify the genetic character of the outbreak virus in the area, we conducted whole-genome sequencing analysis on the samples positive for the DENV1 along with real-time PCR. Study design In total, 1026 blood samples were collected from patients with suspected dengue fever in Ha Nam and Hai Duong province, nearby areas of the capital of Vietnam. After screening by real-time PCR, 40 of DENV1 positive samples were subjected to whole-genome sequencing, and 28 complete coding sequences were obtained. Results All 28 sequences were genotype I of DENV1, which is dominant in the southeast and East Asian countries. The phylogenetic analysis of the E region showed that they fell into a single cluster with the reported sequences from Vietnam between 2009 and 2016, in which the isolates from other countries are very rare. Our results suggested that the 2017 outbreak in the area was caused by locally circulating viruses. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 50 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Dengue virus Vietnam Viral genome Virus circulation Arctic medicine. Tropical medicine RC955-962 |
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Dengue virus Vietnam Viral genome Virus circulation Arctic medicine. Tropical medicine RC955-962 Taichiro Takemura Co Thach Nguyen Ha Chau Pham Thuy Trang Nguyen Vu Mai Phuong Hoang Le Khanh Hang Nguyen Takeshi Nabeshima Thi Thu Thuy Nguyen Thi Quynh Mai Le Meng Ling Moi Kouichi Morita Futoshi Hasebe The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
topic_facet |
Dengue virus Vietnam Viral genome Virus circulation Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Dengue virus (DENV) is a member of insect vector-borne viruses, and it causes dengue fever. Southeast Asia is the epi-center of dengue fever in the world. The characterization of the virus is essential to identify the transmission and evolution of DENV. Objectives In 2017, there was an outbreak of Dengue virus type 1 (DENV1) in northern Vietnam and the neighboring countries. To identify the genetic character of the outbreak virus in the area, we conducted whole-genome sequencing analysis on the samples positive for the DENV1 along with real-time PCR. Study design In total, 1026 blood samples were collected from patients with suspected dengue fever in Ha Nam and Hai Duong province, nearby areas of the capital of Vietnam. After screening by real-time PCR, 40 of DENV1 positive samples were subjected to whole-genome sequencing, and 28 complete coding sequences were obtained. Results All 28 sequences were genotype I of DENV1, which is dominant in the southeast and East Asian countries. The phylogenetic analysis of the E region showed that they fell into a single cluster with the reported sequences from Vietnam between 2009 and 2016, in which the isolates from other countries are very rare. Our results suggested that the 2017 outbreak in the area was caused by locally circulating viruses. |
format |
Article in Journal/Newspaper |
author |
Taichiro Takemura Co Thach Nguyen Ha Chau Pham Thuy Trang Nguyen Vu Mai Phuong Hoang Le Khanh Hang Nguyen Takeshi Nabeshima Thi Thu Thuy Nguyen Thi Quynh Mai Le Meng Ling Moi Kouichi Morita Futoshi Hasebe |
author_facet |
Taichiro Takemura Co Thach Nguyen Ha Chau Pham Thuy Trang Nguyen Vu Mai Phuong Hoang Le Khanh Hang Nguyen Takeshi Nabeshima Thi Thu Thuy Nguyen Thi Quynh Mai Le Meng Ling Moi Kouichi Morita Futoshi Hasebe |
author_sort |
Taichiro Takemura |
title |
The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
title_short |
The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
title_full |
The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
title_fullStr |
The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
title_full_unstemmed |
The 2017 Dengue virus 1 outbreak in northern Vietnam was caused by a locally circulating virus group |
title_sort |
2017 dengue virus 1 outbreak in northern vietnam was caused by a locally circulating virus group |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s41182-021-00386-0 https://doaj.org/article/ed611bc94d0442ab84c1c86a5977edb1 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
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Arctic |
op_source |
Tropical Medicine and Health, Vol 50, Iss 1, Pp 1-5 (2022) |
op_relation |
https://doi.org/10.1186/s41182-021-00386-0 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00386-0 1349-4147 https://doaj.org/article/ed611bc94d0442ab84c1c86a5977edb1 |
op_doi |
https://doi.org/10.1186/s41182-021-00386-0 |
container_title |
Tropical Medicine and Health |
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50 |
container_issue |
1 |
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1766341288015167488 |