Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B
BACKGROUND: The quantitation of serum HBeAg is not commonly used to monitor viral response to therapy in chronic hepatitis B. METHODS: In this study, 21 patients receiving varying therapies were followed and their viral response monitored by concomitant viral load and HBeAg quantitation in order to...
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ftdoajarticles:oai:doaj.org/article:ed27dde5acba4238a211b6e11337d1d8 2024-09-09T19:28:38+00:00 Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B Luiz Caetano da Silva Maria Luiza da Nova Suzane Kioko Ono-Nita João Renato Rebello Pinho Roberta Sitnik Vera Aparecida dos Santos Flair José Carrilho 2009-10-01T00:00:00Z https://doi.org/10.1590/S0036-46652009000500005 https://doaj.org/article/ed27dde5acba4238a211b6e11337d1d8 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000500005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652009000500005 0036-4665 1678-9946 https://doaj.org/article/ed27dde5acba4238a211b6e11337d1d8 Revista do Instituto de Medicina Tropical de São Paulo, Vol 51, Iss 5, Pp 261-268 (2009) Hepatitis B Serological markers Treatment response Treatment follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1590/S0036-46652009000500005 2024-08-05T17:49:30Z BACKGROUND: The quantitation of serum HBeAg is not commonly used to monitor viral response to therapy in chronic hepatitis B. METHODS: In this study, 21 patients receiving varying therapies were followed and their viral response monitored by concomitant viral load and HBeAg quantitation in order to study the meaning and the kinetics of both parameters. RESULTS: It was possible to distinguish between three different patterns of viral response. The first was characterized by a simultaneous decrease in serum HBV DNA and HBeAg. The second pattern was characterized by a decrease in serum HBeAg but persistent detection of HBV DNA. The third pattern was characterized by undetectable HBV DNA with persistent HBeAg positivity, which points to a non-response (Pattern III-B) except when HBeAg levels showed a slow but steady drop, characterizing a "slow responder" patient (Pattern III-A). CONCLUSIONS: The first pattern is compatible with a viral response. A long-term HBeAg seropositivity with a slow and persistent decrease (Pattern III-A) is also compatible with a viral response and calls for a prolongation of anti-viral treatment. INTRODUÇÃO: A quantificação do AgHBe sérico não é habitualmente utilizada para monitorizar a resposta viral ao tratamento da hepatite crônica B. MÉTODOS: Neste estudo, 21 pacientes sob tratamento com diferentes terapias foram acompanhados e a resposta viral monitorizada pela quantificação concomitante da carga viral e do AgHBe a fim de investigar o significado e a cinética de ambos os parâmetros. RESULTADOS: Distinguiram-se três diferentes padrões de resposta viral. O primeiro caracterizou-se pela redução simultânea do HBV DNA e AgHBe séricos. O segundo padrão caracterizou-se por uma redução do AgHBe porém com detecção persistente do HBV DNA. O terceiro padrão caracterizou-se por HBV DNA indetectável com positividade persistente do AgHBe, sugerindo ausência de resposta (Padrão III-B), exceto quando os níveis de AgHBe mostraram uma queda lenta porém persistente, caracterizando um "respondedor ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sob’ ENVELOPE(66.156,66.156,66.322,66.322) Revista do Instituto de Medicina Tropical de São Paulo 51 5 261 268 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hepatitis B Serological markers Treatment response Treatment follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Hepatitis B Serological markers Treatment response Treatment follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Luiz Caetano da Silva Maria Luiza da Nova Suzane Kioko Ono-Nita João Renato Rebello Pinho Roberta Sitnik Vera Aparecida dos Santos Flair José Carrilho Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
topic_facet |
Hepatitis B Serological markers Treatment response Treatment follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
BACKGROUND: The quantitation of serum HBeAg is not commonly used to monitor viral response to therapy in chronic hepatitis B. METHODS: In this study, 21 patients receiving varying therapies were followed and their viral response monitored by concomitant viral load and HBeAg quantitation in order to study the meaning and the kinetics of both parameters. RESULTS: It was possible to distinguish between three different patterns of viral response. The first was characterized by a simultaneous decrease in serum HBV DNA and HBeAg. The second pattern was characterized by a decrease in serum HBeAg but persistent detection of HBV DNA. The third pattern was characterized by undetectable HBV DNA with persistent HBeAg positivity, which points to a non-response (Pattern III-B) except when HBeAg levels showed a slow but steady drop, characterizing a "slow responder" patient (Pattern III-A). CONCLUSIONS: The first pattern is compatible with a viral response. A long-term HBeAg seropositivity with a slow and persistent decrease (Pattern III-A) is also compatible with a viral response and calls for a prolongation of anti-viral treatment. INTRODUÇÃO: A quantificação do AgHBe sérico não é habitualmente utilizada para monitorizar a resposta viral ao tratamento da hepatite crônica B. MÉTODOS: Neste estudo, 21 pacientes sob tratamento com diferentes terapias foram acompanhados e a resposta viral monitorizada pela quantificação concomitante da carga viral e do AgHBe a fim de investigar o significado e a cinética de ambos os parâmetros. RESULTADOS: Distinguiram-se três diferentes padrões de resposta viral. O primeiro caracterizou-se pela redução simultânea do HBV DNA e AgHBe séricos. O segundo padrão caracterizou-se por uma redução do AgHBe porém com detecção persistente do HBV DNA. O terceiro padrão caracterizou-se por HBV DNA indetectável com positividade persistente do AgHBe, sugerindo ausência de resposta (Padrão III-B), exceto quando os níveis de AgHBe mostraram uma queda lenta porém persistente, caracterizando um "respondedor ... |
format |
Article in Journal/Newspaper |
author |
Luiz Caetano da Silva Maria Luiza da Nova Suzane Kioko Ono-Nita João Renato Rebello Pinho Roberta Sitnik Vera Aparecida dos Santos Flair José Carrilho |
author_facet |
Luiz Caetano da Silva Maria Luiza da Nova Suzane Kioko Ono-Nita João Renato Rebello Pinho Roberta Sitnik Vera Aparecida dos Santos Flair José Carrilho |
author_sort |
Luiz Caetano da Silva |
title |
Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
title_short |
Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
title_full |
Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
title_fullStr |
Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
title_full_unstemmed |
Simultaneous quantitation of serum HBV DNA and HBeAg can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis B A quantificação simultânea do DNA VHB e do AgHBe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica B |
title_sort |
simultaneous quantitation of serum hbv dna and hbeag can distinguish between slow and fast viral responses to antiviral therapy in patients with chronic hepatitis b a quantificação simultânea do dna vhb e do aghbe séricos podem distinguir entre resposta viral lenta e rápida à terapêutica anti-viral em pacientes com hepatite crônica b |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2009 |
url |
https://doi.org/10.1590/S0036-46652009000500005 https://doaj.org/article/ed27dde5acba4238a211b6e11337d1d8 |
long_lat |
ENVELOPE(66.156,66.156,66.322,66.322) |
geographic |
Arctic Sob’ |
geographic_facet |
Arctic Sob’ |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 51, Iss 5, Pp 261-268 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000500005 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652009000500005 0036-4665 1678-9946 https://doaj.org/article/ed27dde5acba4238a211b6e11337d1d8 |
op_doi |
https://doi.org/10.1590/S0036-46652009000500005 |
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51 |
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