Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections.
Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also known as the "helminth effect". Man...
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ftdoajarticles:oai:doaj.org/article:eceec56b626c4ed6b55879553d2ea6d6 2023-05-15T15:08:29+02:00 Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. Guangyan Zhou Mary M Stevenson Timothy G Geary Jianguo Xia 2016-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004624 https://doaj.org/article/eceec56b626c4ed6b55879553d2ea6d6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4826001?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004624 https://doaj.org/article/eceec56b626c4ed6b55879553d2ea6d6 PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004624 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004624 2022-12-30T21:54:50Z Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also known as the "helminth effect". Many investigations have been carried out to study host gene expression profiles during helminth infections. The objective of this study is to determine if there is a common transcriptomic signature characteristic of the helminth effect across multiple helminth species and tissue types. To this end, we performed a comprehensive meta-analysis of publicly available gene expression datasets. After data processing and adjusting for study-specific effects, we identified ~700 differentially expressed genes that are changed consistently during helminth infections. Functional enrichment analyses indicate that upregulated genes are predominantly involved in various immune functions, including immunomodulation, immune signaling, inflammation, pathogen recognition and antigen presentation. Down-regulated genes are mainly involved in metabolic process, with only a few of them are involved in immune regulation. This common immune gene signature confirms previous observations and indicates that the helminth effect is robust across different parasite species as well as host tissue types. To the best of our knowledge, this study is the first comprehensive meta-analysis of host transcriptome profiles during helminth infections. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 4 e0004624 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Guangyan Zhou Mary M Stevenson Timothy G Geary Jianguo Xia Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also known as the "helminth effect". Many investigations have been carried out to study host gene expression profiles during helminth infections. The objective of this study is to determine if there is a common transcriptomic signature characteristic of the helminth effect across multiple helminth species and tissue types. To this end, we performed a comprehensive meta-analysis of publicly available gene expression datasets. After data processing and adjusting for study-specific effects, we identified ~700 differentially expressed genes that are changed consistently during helminth infections. Functional enrichment analyses indicate that upregulated genes are predominantly involved in various immune functions, including immunomodulation, immune signaling, inflammation, pathogen recognition and antigen presentation. Down-regulated genes are mainly involved in metabolic process, with only a few of them are involved in immune regulation. This common immune gene signature confirms previous observations and indicates that the helminth effect is robust across different parasite species as well as host tissue types. To the best of our knowledge, this study is the first comprehensive meta-analysis of host transcriptome profiles during helminth infections. |
format |
Article in Journal/Newspaper |
author |
Guangyan Zhou Mary M Stevenson Timothy G Geary Jianguo Xia |
author_facet |
Guangyan Zhou Mary M Stevenson Timothy G Geary Jianguo Xia |
author_sort |
Guangyan Zhou |
title |
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
title_short |
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
title_full |
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
title_fullStr |
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
title_full_unstemmed |
Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections. |
title_sort |
comprehensive transcriptome meta-analysis to characterize host immune responses in helminth infections. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004624 https://doaj.org/article/eceec56b626c4ed6b55879553d2ea6d6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004624 (2016) |
op_relation |
http://europepmc.org/articles/PMC4826001?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004624 https://doaj.org/article/eceec56b626c4ed6b55879553d2ea6d6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004624 |
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PLOS Neglected Tropical Diseases |
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10 |
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4 |
container_start_page |
e0004624 |
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1766339838695440384 |