Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness
Background. Thrombocytopenia is the most common hematological abnormality in patients with acute malaria. This study aimed to determine the role of thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. Method. A cross-sectional health facility-based study was co...
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ftdoajarticles:oai:doaj.org/article:ecd8ec409d6040babc46eb905fa273a4 2024-09-09T19:27:20+00:00 Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness Angesom Gebreweld Yonas Erkihun Daniel Getacher Feleke Gebru Hailu Temesgen Fiseha 2021-01-01T00:00:00Z https://doi.org/10.1155/2021/5585272 https://doaj.org/article/ecd8ec409d6040babc46eb905fa273a4 EN eng Wiley http://dx.doi.org/10.1155/2021/5585272 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2021/5585272 https://doaj.org/article/ecd8ec409d6040babc46eb905fa273a4 Journal of Tropical Medicine, Vol 2021 (2021) Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1155/2021/5585272 2024-08-05T17:48:40Z Background. Thrombocytopenia is the most common hematological abnormality in patients with acute malaria. This study aimed to determine the role of thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. Method. A cross-sectional health facility-based study was conducted on 423 consecutively selected acute febrile patients at Ataye District Hospital from February to May 2019 GC. A complete blood count and malaria microscopy were performed for each acute febrile patient. ROC curve analysis was performed to calculate sensitivity, specificity, positive predictive value, and negative predictive value of platelet count in predicting malaria. A P ≤ 0.05 was considered statistically significant. Result. Out of the 423 acute febrile patients, 73 (17.3%) were microscopically confirmed malaria cases and the rest 350 (82.7%) patients had negative blood film results. Of the microscopically confirmed malaria cases, 55 (75.34%) were P. vivax and 18 (24.66%) were P. falciparum. The prevalence of thrombocytopenia among malaria patients (79.5%) was significantly higher than those in malaria negative acute febrile patients (13.7%), P < 0.001. About 67% malaria-infected patients had mild to moderate thrombocytopenia and 12.3% had severe thrombocytopenia. The ROC analysis demonstrated platelet counts <150,000/μl as an optimal cutoff value with 0.893 area under the curve, 79.5% sensitivity, 86.3% specificity, 95.3% negative predictive value, and 54.7% positive predictive value to predict malaria. Conclusion. Malaria is still among the major public health problems in the country. Thrombocytopenia is a very good discriminatory test for the presence or absence of malaria with 79.5% sensitivity and 86.3% specificity. Therefore, this may be used in addition to the clinical and microscopic parameters to heighten the suspicion of malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2021 1 6 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Angesom Gebreweld Yonas Erkihun Daniel Getacher Feleke Gebru Hailu Temesgen Fiseha Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Thrombocytopenia is the most common hematological abnormality in patients with acute malaria. This study aimed to determine the role of thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. Method. A cross-sectional health facility-based study was conducted on 423 consecutively selected acute febrile patients at Ataye District Hospital from February to May 2019 GC. A complete blood count and malaria microscopy were performed for each acute febrile patient. ROC curve analysis was performed to calculate sensitivity, specificity, positive predictive value, and negative predictive value of platelet count in predicting malaria. A P ≤ 0.05 was considered statistically significant. Result. Out of the 423 acute febrile patients, 73 (17.3%) were microscopically confirmed malaria cases and the rest 350 (82.7%) patients had negative blood film results. Of the microscopically confirmed malaria cases, 55 (75.34%) were P. vivax and 18 (24.66%) were P. falciparum. The prevalence of thrombocytopenia among malaria patients (79.5%) was significantly higher than those in malaria negative acute febrile patients (13.7%), P < 0.001. About 67% malaria-infected patients had mild to moderate thrombocytopenia and 12.3% had severe thrombocytopenia. The ROC analysis demonstrated platelet counts <150,000/μl as an optimal cutoff value with 0.893 area under the curve, 79.5% sensitivity, 86.3% specificity, 95.3% negative predictive value, and 54.7% positive predictive value to predict malaria. Conclusion. Malaria is still among the major public health problems in the country. Thrombocytopenia is a very good discriminatory test for the presence or absence of malaria with 79.5% sensitivity and 86.3% specificity. Therefore, this may be used in addition to the clinical and microscopic parameters to heighten the suspicion of malaria. |
format |
Article in Journal/Newspaper |
author |
Angesom Gebreweld Yonas Erkihun Daniel Getacher Feleke Gebru Hailu Temesgen Fiseha |
author_facet |
Angesom Gebreweld Yonas Erkihun Daniel Getacher Feleke Gebru Hailu Temesgen Fiseha |
author_sort |
Angesom Gebreweld |
title |
Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
title_short |
Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
title_full |
Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
title_fullStr |
Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
title_full_unstemmed |
Thrombocytopenia as a Diagnostic Marker for Malaria in Patients with Acute Febrile Illness |
title_sort |
thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness |
publisher |
Wiley |
publishDate |
2021 |
url |
https://doi.org/10.1155/2021/5585272 https://doaj.org/article/ecd8ec409d6040babc46eb905fa273a4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2021 (2021) |
op_relation |
http://dx.doi.org/10.1155/2021/5585272 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2021/5585272 https://doaj.org/article/ecd8ec409d6040babc46eb905fa273a4 |
op_doi |
https://doi.org/10.1155/2021/5585272 |
container_title |
Journal of Tropical Medicine |
container_volume |
2021 |
container_start_page |
1 |
op_container_end_page |
6 |
_version_ |
1809896782970224640 |