Tick-borne rickettsioses, neglected emerging diseases in rural Senegal.
BACKGROUND: Rickettsioses are one of the most important causes of systemic febrile illness among travelers from developed countries, but little is known about their incidence in indigenous populations, especially in West Africa. METHODOLOGY/PRINCIPAL FINDINGS: Overall seroprevalence evaluated by imm...
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ftdoajarticles:oai:doaj.org/article:ec2e78d461bf4891a7cf9ef10ca72424 2023-05-15T15:16:33+02:00 Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. Oleg Mediannikov Georges Diatta Florence Fenollar Cheikh Sokhna Jean-François Trape Didier Raoult 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000821 https://doaj.org/article/ec2e78d461bf4891a7cf9ef10ca72424 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2939048?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000821 https://doaj.org/article/ec2e78d461bf4891a7cf9ef10ca72424 PLoS Neglected Tropical Diseases, Vol 4, Iss 9, p e1000888 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000821 2022-12-31T10:52:42Z BACKGROUND: Rickettsioses are one of the most important causes of systemic febrile illness among travelers from developed countries, but little is known about their incidence in indigenous populations, especially in West Africa. METHODOLOGY/PRINCIPAL FINDINGS: Overall seroprevalence evaluated by immunofluorescence using six rickettsial antigens (spotted fever and typhus group) in rural populations of two villages of the Sine-Saloum region of Senegal was found to be 21.4% and 51% for spotted fever group rickettsiae for Dielmo and Ndiop villages, respectively. We investigated the role of tick-borne rickettsiae as the cause of acute non-malarial febrile diseases in the same villages. The incidence of rickettsial DNA in 204 blood samples from 134 (62M and 72F) febrile patients negative for malaria was studied. DNA extracted from whole blood was tested by two qPCR systems. Rickettsial DNA was found in nine patients, eight with Rickettsia felis (separately reported). For the first time in West Africa, Rickettsia conorii was diagnosed in one patient. We also tested 2,767 Ixodid ticks collected in two regions of Senegal (Niakhar and Sine-Saloum) from domestic animals (cows, sheep, goats, donkeys and horses) by qPCR and identified five different pathogenic rickettsiae. We found the following: Rickettsia aeschlimannii in Hyalomma marginatum rufipes (51.3% and 44.8% in Niakhar and Sine-Saloum region, respectively), in Hyalomma truncatum (6% and 6.8%) and in Rhipicephalus evertsi evertsi (0.5%, only in Niakhar); R. c. conorii in Rh. e. evertsi (0.4%, only in Sine-Saloum); Rickettsia massiliae in Rhipicephalus guilhoni (22.4%, only in Niakhar); Rickettsia sibirica mongolitimonae in Hyalomma truncatum (13.5%, only in Sine-Saloum); and Rickettsia africae in Rhipicephalus evertsi evertsi (0.7% and 0.4% in Niakhar and Sine-Saloum region, respectively) as well as in Rhipicephalus annulatus (20%, only in Sine-Saloum). We isolated two rickettsial strains from H. truncatum: R. s. mongolitimonae and R. aeschlimannii. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 9 e821 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oleg Mediannikov Georges Diatta Florence Fenollar Cheikh Sokhna Jean-François Trape Didier Raoult Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Rickettsioses are one of the most important causes of systemic febrile illness among travelers from developed countries, but little is known about their incidence in indigenous populations, especially in West Africa. METHODOLOGY/PRINCIPAL FINDINGS: Overall seroprevalence evaluated by immunofluorescence using six rickettsial antigens (spotted fever and typhus group) in rural populations of two villages of the Sine-Saloum region of Senegal was found to be 21.4% and 51% for spotted fever group rickettsiae for Dielmo and Ndiop villages, respectively. We investigated the role of tick-borne rickettsiae as the cause of acute non-malarial febrile diseases in the same villages. The incidence of rickettsial DNA in 204 blood samples from 134 (62M and 72F) febrile patients negative for malaria was studied. DNA extracted from whole blood was tested by two qPCR systems. Rickettsial DNA was found in nine patients, eight with Rickettsia felis (separately reported). For the first time in West Africa, Rickettsia conorii was diagnosed in one patient. We also tested 2,767 Ixodid ticks collected in two regions of Senegal (Niakhar and Sine-Saloum) from domestic animals (cows, sheep, goats, donkeys and horses) by qPCR and identified five different pathogenic rickettsiae. We found the following: Rickettsia aeschlimannii in Hyalomma marginatum rufipes (51.3% and 44.8% in Niakhar and Sine-Saloum region, respectively), in Hyalomma truncatum (6% and 6.8%) and in Rhipicephalus evertsi evertsi (0.5%, only in Niakhar); R. c. conorii in Rh. e. evertsi (0.4%, only in Sine-Saloum); Rickettsia massiliae in Rhipicephalus guilhoni (22.4%, only in Niakhar); Rickettsia sibirica mongolitimonae in Hyalomma truncatum (13.5%, only in Sine-Saloum); and Rickettsia africae in Rhipicephalus evertsi evertsi (0.7% and 0.4% in Niakhar and Sine-Saloum region, respectively) as well as in Rhipicephalus annulatus (20%, only in Sine-Saloum). We isolated two rickettsial strains from H. truncatum: R. s. mongolitimonae and R. aeschlimannii. ... |
format |
Article in Journal/Newspaper |
author |
Oleg Mediannikov Georges Diatta Florence Fenollar Cheikh Sokhna Jean-François Trape Didier Raoult |
author_facet |
Oleg Mediannikov Georges Diatta Florence Fenollar Cheikh Sokhna Jean-François Trape Didier Raoult |
author_sort |
Oleg Mediannikov |
title |
Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
title_short |
Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
title_full |
Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
title_fullStr |
Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
title_full_unstemmed |
Tick-borne rickettsioses, neglected emerging diseases in rural Senegal. |
title_sort |
tick-borne rickettsioses, neglected emerging diseases in rural senegal. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000821 https://doaj.org/article/ec2e78d461bf4891a7cf9ef10ca72424 |
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Arctic |
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Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 9, p e1000888 (2010) |
op_relation |
http://europepmc.org/articles/PMC2939048?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000821 https://doaj.org/article/ec2e78d461bf4891a7cf9ef10ca72424 |
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https://doi.org/10.1371/journal.pntd.0000821 |
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PLoS Neglected Tropical Diseases |
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e821 |
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