DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876....
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Belgorod National Research University
2016
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ftdoajarticles:oai:doaj.org/article:ec29302af6604d10ab8987a2284677a4 2024-01-07T09:42:38+01:00 DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION Andrey Buzov Alexandr Kulikov Tatyana Avtina Mikhail Pokrovskii Ol'ga Osipova 2016-03-01T00:00:00Z https://doi.org/10.18413/2313-8971-2016-2-1-52-57 https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 EN eng Belgorod National Research University https://rrpharmacology.pensoft.net/article/31041/download/pdf/ https://rrpharmacology.pensoft.net/article/31041/download/xml/ https://rrpharmacology.pensoft.net/article/31041/ https://doaj.org/toc/2658-381X doi:10.18413/2313-8971-2016-2-1-52-57 2658-381X https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 Research Results in Pharmacology, Vol 2, Iss 1, Pp 52-57 (2016) antidiabetic agent С7070 the blood plasma of rat Therapeutics. Pharmacology RM1-950 article 2016 ftdoajarticles https://doi.org/10.18413/2313-8971-2016-2-1-52-57 2023-12-10T01:53:15Z We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4. Article in Journal/Newspaper Carbonic acid Directory of Open Access Journals: DOAJ Articles RESEARCH RESULT Pharmacology and Clinical Pharmacology 2 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antidiabetic agent С7070 the blood plasma of rat Therapeutics. Pharmacology RM1-950 |
spellingShingle |
antidiabetic agent С7070 the blood plasma of rat Therapeutics. Pharmacology RM1-950 Andrey Buzov Alexandr Kulikov Tatyana Avtina Mikhail Pokrovskii Ol'ga Osipova DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
topic_facet |
antidiabetic agent С7070 the blood plasma of rat Therapeutics. Pharmacology RM1-950 |
description |
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4. |
format |
Article in Journal/Newspaper |
author |
Andrey Buzov Alexandr Kulikov Tatyana Avtina Mikhail Pokrovskii Ol'ga Osipova |
author_facet |
Andrey Buzov Alexandr Kulikov Tatyana Avtina Mikhail Pokrovskii Ol'ga Osipova |
author_sort |
Andrey Buzov |
title |
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
title_short |
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
title_full |
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
title_fullStr |
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
title_full_unstemmed |
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION |
title_sort |
development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection |
publisher |
Belgorod National Research University |
publishDate |
2016 |
url |
https://doi.org/10.18413/2313-8971-2016-2-1-52-57 https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Research Results in Pharmacology, Vol 2, Iss 1, Pp 52-57 (2016) |
op_relation |
https://rrpharmacology.pensoft.net/article/31041/download/pdf/ https://rrpharmacology.pensoft.net/article/31041/download/xml/ https://rrpharmacology.pensoft.net/article/31041/ https://doaj.org/toc/2658-381X doi:10.18413/2313-8971-2016-2-1-52-57 2658-381X https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 |
op_doi |
https://doi.org/10.18413/2313-8971-2016-2-1-52-57 |
container_title |
RESEARCH RESULT Pharmacology and Clinical Pharmacology |
container_volume |
2 |
container_issue |
1 |
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1787423684202332160 |