DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876....

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Published in:RESEARCH RESULT Pharmacology and Clinical Pharmacology
Main Authors: Andrey Buzov, Alexandr Kulikov, Tatyana Avtina, Mikhail Pokrovskii, Ol'ga Osipova
Format: Article in Journal/Newspaper
Language:English
Published: Belgorod National Research University 2016
Subjects:
antidiabetic agent
С7070
the blood plasma of rat
Therapeutics. Pharmacology
RM1-950
Carbonic acid
Online Access:https://doi.org/10.18413/2313-8971-2016-2-1-52-57
https://doaj.org/article/ec29302af6604d10ab8987a2284677a4
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spelling ftdoajarticles:oai:doaj.org/article:ec29302af6604d10ab8987a2284677a4 2024-01-07T09:42:38+01:00 DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION Andrey Buzov Alexandr Kulikov Tatyana Avtina Mikhail Pokrovskii Ol'ga Osipova 2016-03-01T00:00:00Z https://doi.org/10.18413/2313-8971-2016-2-1-52-57 https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 EN eng Belgorod National Research University https://rrpharmacology.pensoft.net/article/31041/download/pdf/ https://rrpharmacology.pensoft.net/article/31041/download/xml/ https://rrpharmacology.pensoft.net/article/31041/ https://doaj.org/toc/2658-381X doi:10.18413/2313-8971-2016-2-1-52-57 2658-381X https://doaj.org/article/ec29302af6604d10ab8987a2284677a4 Research Results in Pharmacology, Vol 2, Iss 1, Pp 52-57 (2016) antidiabetic agent С7070 the blood plasma of rat Therapeutics. Pharmacology RM1-950 article 2016 ftdoajarticles https://doi.org/10.18413/2313-8971-2016-2-1-52-57 2023-12-10T01:53:15Z We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4. Article in Journal/Newspaper Carbonic acid Directory of Open Access Journals: DOAJ Articles RESEARCH RESULT Pharmacology and Clinical Pharmacology 2 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic antidiabetic agent
С7070
the blood plasma of rat
Therapeutics. Pharmacology
RM1-950
spellingShingle antidiabetic agent
С7070
the blood plasma of rat
Therapeutics. Pharmacology
RM1-950
Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
topic_facet antidiabetic agent
С7070
the blood plasma of rat
Therapeutics. Pharmacology
RM1-950
description We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.
format Article in Journal/Newspaper
author Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
author_facet Andrey Buzov
Alexandr Kulikov
Tatyana Avtina
Mikhail Pokrovskii
Ol'ga Osipova
author_sort Andrey Buzov
title DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_short DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_fullStr DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_full_unstemmed DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
title_sort development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection
publisher Belgorod National Research University
publishDate 2016
url https://doi.org/10.18413/2313-8971-2016-2-1-52-57
https://doaj.org/article/ec29302af6604d10ab8987a2284677a4
genre Carbonic acid
genre_facet Carbonic acid
op_source Research Results in Pharmacology, Vol 2, Iss 1, Pp 52-57 (2016)
op_relation https://rrpharmacology.pensoft.net/article/31041/download/pdf/
https://rrpharmacology.pensoft.net/article/31041/download/xml/
https://rrpharmacology.pensoft.net/article/31041/
https://doaj.org/toc/2658-381X
doi:10.18413/2313-8971-2016-2-1-52-57
2658-381X
https://doaj.org/article/ec29302af6604d10ab8987a2284677a4
op_doi https://doi.org/10.18413/2313-8971-2016-2-1-52-57
container_title RESEARCH RESULT Pharmacology and Clinical Pharmacology
container_volume 2
container_issue 1
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