Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century.
Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakut...
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ftdoajarticles:oai:doaj.org/article:ec114af1920343429322fe0eeced0f26 2023-05-15T18:44:33+02:00 Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. Henri Dabernat Catherine Thèves Caroline Bouakaze Dariya Nikolaeva Christine Keyser Igor Mokrousov Annie Géraut Sylvie Duchesne Patrice Gérard Anatoly N Alexeev Eric Crubézy Bertrand Ludes 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0089877 https://doaj.org/article/ec114af1920343429322fe0eeced0f26 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3935942?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0089877 https://doaj.org/article/ec114af1920343429322fe0eeced0f26 PLoS ONE, Vol 9, Iss 2, p e89877 (2014) Medicine R Science Q article 2014 ftdoajarticles https://doi.org/10.1371/journal.pone.0089877 2022-12-31T03:44:25Z Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16(th)-19(th) century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17(th) century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19(th) century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. Article in Journal/Newspaper Yakut Yakutia Siberia Directory of Open Access Journals: DOAJ Articles PLoS ONE 9 2 e89877 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Henri Dabernat Catherine Thèves Caroline Bouakaze Dariya Nikolaeva Christine Keyser Igor Mokrousov Annie Géraut Sylvie Duchesne Patrice Gérard Anatoly N Alexeev Eric Crubézy Bertrand Ludes Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
topic_facet |
Medicine R Science Q |
description |
Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16(th)-19(th) century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17(th) century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19(th) century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. |
format |
Article in Journal/Newspaper |
author |
Henri Dabernat Catherine Thèves Caroline Bouakaze Dariya Nikolaeva Christine Keyser Igor Mokrousov Annie Géraut Sylvie Duchesne Patrice Gérard Anatoly N Alexeev Eric Crubézy Bertrand Ludes |
author_facet |
Henri Dabernat Catherine Thèves Caroline Bouakaze Dariya Nikolaeva Christine Keyser Igor Mokrousov Annie Géraut Sylvie Duchesne Patrice Gérard Anatoly N Alexeev Eric Crubézy Bertrand Ludes |
author_sort |
Henri Dabernat |
title |
Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
title_short |
Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
title_full |
Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
title_fullStr |
Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
title_full_unstemmed |
Tuberculosis epidemiology and selection in an autochthonous Siberian population from the 16th-19th century. |
title_sort |
tuberculosis epidemiology and selection in an autochthonous siberian population from the 16th-19th century. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pone.0089877 https://doaj.org/article/ec114af1920343429322fe0eeced0f26 |
genre |
Yakut Yakutia Siberia |
genre_facet |
Yakut Yakutia Siberia |
op_source |
PLoS ONE, Vol 9, Iss 2, p e89877 (2014) |
op_relation |
http://europepmc.org/articles/PMC3935942?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0089877 https://doaj.org/article/ec114af1920343429322fe0eeced0f26 |
op_doi |
https://doi.org/10.1371/journal.pone.0089877 |
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PLoS ONE |
container_volume |
9 |
container_issue |
2 |
container_start_page |
e89877 |
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