Comparison of Plasmodium falciparum transfection methods

Abstract The development of an electroporation based transfection method for Plasmodium falciparum has been very successful for the study of some genes but its efficiency remains very low. While alternative approaches have been documented, electroporation of infected red blood cells generally remain...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Trenholme Katharine R, Gardiner Donald L, Hawthorne Paula L, Lawrie Paula M, Skinner-Adams Tina S
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2003
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Online Access:https://doi.org/10.1186/1475-2875-2-19
https://doaj.org/article/ec0a2135204f453788279235dda5651f
Description
Summary:Abstract The development of an electroporation based transfection method for Plasmodium falciparum has been very successful for the study of some genes but its efficiency remains very low. While alternative approaches have been documented, electroporation of infected red blood cells generally remains the method of choice for introducing DNA into P. falciparum . In this paper we compare four published transfection techniques in their ability to achieve stable transfections.

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