Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort.
Background Chikungunya-fever (CHIKF) remains a public health major issue. It is clinically divided into three phases: acute, post-acute and chronic. Chronic cases correspond to 25-40% individuals and, though most of them are characterized by long-lasting arthralgia alone, many of them exhibit persis...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0011037 https://doaj.org/article/ebc2cddf188d496aadd74ca7f4d72ac4 |
id |
ftdoajarticles:oai:doaj.org/article:ebc2cddf188d496aadd74ca7f4d72ac4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ebc2cddf188d496aadd74ca7f4d72ac4 2023-05-15T15:15:08+02:00 Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. Carolina Dos Santos Lázari Mariana Severo Ramundo Felipe Ten-Caten Clarisse S Bressan Ana Maria Bispo de Filippis Erika Regina Manuli Isabella de Moraes Geovana Maria Pereira Marina Farrel Côrtes Darlan da Silva Candido Alexandra L Gerber Ana Paula Guimarães Nuno Rodrigues Faria Helder I Nakaya Ana Tereza R Vasconcelos Patrícia Brasil Gláucia Paranhos-Baccalà Ester Cerdeira Sabino 2023-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011037 https://doaj.org/article/ebc2cddf188d496aadd74ca7f4d72ac4 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011037 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011037 https://doaj.org/article/ebc2cddf188d496aadd74ca7f4d72ac4 PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011037 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011037 2023-03-05T01:33:15Z Background Chikungunya-fever (CHIKF) remains a public health major issue. It is clinically divided into three phases: acute, post-acute and chronic. Chronic cases correspond to 25-40% individuals and, though most of them are characterized by long-lasting arthralgia alone, many of them exhibit persistent or recurrent inflammatory signs that define post-Chikungunya chronic inflammatory joint disease (pCHIKV-CIJD). We aimed to identify early clinical markers of evolution to pCHIKV-CIJD during acute and post-acute phases. Methodology/principal findings We studied a prospective cohort of CHIKF-confirmed volunteers with longitudinal clinical data collection from symptoms onset up to 90 days, including a 21-day visit (D21). Of 169 patients with CHIKF, 86 (50.9%) completed the follow-up, from whom 39 met clinical criteria for pCHIKV-CIJD (45.3%). The relative risk of chronification was higher in women compared to men (RR = 1.52; 95% CI = 1.15-1.99; FDR = 0.03). None of the symptoms or signs presented at D0 behaved as an early predictor of pCHIKV-CIJD, while being symptomatic at D21 was a risk factor for chronification (RR = 1.31; 95% CI = 1.09-1.55; FDR = 0.03). Significance was also observed for joint pain (RR = 1.35; 95% CI = 1.12-1.61; FDR = 0.02), reported edema (RR = 3.61; 95% CI = 1.44-9.06; FDR = 0.03), reported hand and/or feet small joints edema (RR = 4.22; 95% CI = 1.51-11.78; FDR = 0.02), and peri-articular edema observed during physical examination (RR = 2.89; 95% CI = 1.58-5.28; FDR = 0.002). Furthermore, patients with no findings in physical examination at D21 were at lower risk of chronic evolution (RR = 0.41, 95% CI = 0.24-0.70, FDR = 0.01). Twenty-nine pCHIKV-CIJD patients had abnormal articular ultrasonography (90.6% of the examined). The most common findings were synovitis (65.5%) and joint effusion (58.6%). Conclusion This cohort has provided important insights into the prognostic evaluation of CHIKF. Symptomatic sub-acute disease is a relevant predictor of evolution to chronic arthritis with ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 1 e0011037 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Carolina Dos Santos Lázari Mariana Severo Ramundo Felipe Ten-Caten Clarisse S Bressan Ana Maria Bispo de Filippis Erika Regina Manuli Isabella de Moraes Geovana Maria Pereira Marina Farrel Côrtes Darlan da Silva Candido Alexandra L Gerber Ana Paula Guimarães Nuno Rodrigues Faria Helder I Nakaya Ana Tereza R Vasconcelos Patrícia Brasil Gláucia Paranhos-Baccalà Ester Cerdeira Sabino Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Chikungunya-fever (CHIKF) remains a public health major issue. It is clinically divided into three phases: acute, post-acute and chronic. Chronic cases correspond to 25-40% individuals and, though most of them are characterized by long-lasting arthralgia alone, many of them exhibit persistent or recurrent inflammatory signs that define post-Chikungunya chronic inflammatory joint disease (pCHIKV-CIJD). We aimed to identify early clinical markers of evolution to pCHIKV-CIJD during acute and post-acute phases. Methodology/principal findings We studied a prospective cohort of CHIKF-confirmed volunteers with longitudinal clinical data collection from symptoms onset up to 90 days, including a 21-day visit (D21). Of 169 patients with CHIKF, 86 (50.9%) completed the follow-up, from whom 39 met clinical criteria for pCHIKV-CIJD (45.3%). The relative risk of chronification was higher in women compared to men (RR = 1.52; 95% CI = 1.15-1.99; FDR = 0.03). None of the symptoms or signs presented at D0 behaved as an early predictor of pCHIKV-CIJD, while being symptomatic at D21 was a risk factor for chronification (RR = 1.31; 95% CI = 1.09-1.55; FDR = 0.03). Significance was also observed for joint pain (RR = 1.35; 95% CI = 1.12-1.61; FDR = 0.02), reported edema (RR = 3.61; 95% CI = 1.44-9.06; FDR = 0.03), reported hand and/or feet small joints edema (RR = 4.22; 95% CI = 1.51-11.78; FDR = 0.02), and peri-articular edema observed during physical examination (RR = 2.89; 95% CI = 1.58-5.28; FDR = 0.002). Furthermore, patients with no findings in physical examination at D21 were at lower risk of chronic evolution (RR = 0.41, 95% CI = 0.24-0.70, FDR = 0.01). Twenty-nine pCHIKV-CIJD patients had abnormal articular ultrasonography (90.6% of the examined). The most common findings were synovitis (65.5%) and joint effusion (58.6%). Conclusion This cohort has provided important insights into the prognostic evaluation of CHIKF. Symptomatic sub-acute disease is a relevant predictor of evolution to chronic arthritis with ... |
format |
Article in Journal/Newspaper |
author |
Carolina Dos Santos Lázari Mariana Severo Ramundo Felipe Ten-Caten Clarisse S Bressan Ana Maria Bispo de Filippis Erika Regina Manuli Isabella de Moraes Geovana Maria Pereira Marina Farrel Côrtes Darlan da Silva Candido Alexandra L Gerber Ana Paula Guimarães Nuno Rodrigues Faria Helder I Nakaya Ana Tereza R Vasconcelos Patrícia Brasil Gláucia Paranhos-Baccalà Ester Cerdeira Sabino |
author_facet |
Carolina Dos Santos Lázari Mariana Severo Ramundo Felipe Ten-Caten Clarisse S Bressan Ana Maria Bispo de Filippis Erika Regina Manuli Isabella de Moraes Geovana Maria Pereira Marina Farrel Côrtes Darlan da Silva Candido Alexandra L Gerber Ana Paula Guimarães Nuno Rodrigues Faria Helder I Nakaya Ana Tereza R Vasconcelos Patrícia Brasil Gláucia Paranhos-Baccalà Ester Cerdeira Sabino |
author_sort |
Carolina Dos Santos Lázari |
title |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
title_short |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
title_full |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
title_fullStr |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
title_full_unstemmed |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort. |
title_sort |
clinical markers of post-chikungunya chronic inflammatory joint disease: a brazilian cohort. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011037 https://doaj.org/article/ebc2cddf188d496aadd74ca7f4d72ac4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011037 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011037 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011037 https://doaj.org/article/ebc2cddf188d496aadd74ca7f4d72ac4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011037 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
1 |
container_start_page |
e0011037 |
_version_ |
1766345514774691840 |