Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of Aframomum melegueta, Khaya senegalensis and Xylopia aethiopica in hyperreactive onchocerciasis individuals' peripheral blood mononuclear cells.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Gnatoulma Katawa, Essoham Ataba, Manuel Ritter, Oukoe Marthe Amessoudji, Essimanam Rosalie Awesso, Pélagie Edlom Tchadié, Fagdéba David Bara, Fekandine Victoire Douti, Kathrin Arndts, Tchadjobo Tchacondo, Komlan Batawila, Yaovi Ameyapoh, Achim Hoerauf, Simplice D Karou, Laura E Layland
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2022
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Khaya
• Online Access: https://doi.org/10.1371/journal.pntd.0010341; https://doaj.org/article/eba2aa13277f4193b72b5d5444815cc7

Hyperreactive onchocerciasis (HO) is characterized by a severe skin inflammation with elevated Th17-Th2 combined responses. We previously demonstrated the anthelminthic activity of Aframomum melegueta (AM), Xylopia aethiopica (XA) and Khaya senegalensis (KS) used by traditional healers to treat helm...