Human papillomavirus variants among Inuit women in northern Quebec, Canada
Background: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their...
Published in: | International Journal of Circumpolar Health |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Taylor & Francis Group
2015
|
Subjects: | |
Online Access: | https://doi.org/10.3402/ijch.v74.29482 https://doaj.org/article/eb40f831058b4b4db407162bf37e7ed2 |
id |
ftdoajarticles:oai:doaj.org/article:eb40f831058b4b4db407162bf37e7ed2 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:eb40f831058b4b4db407162bf37e7ed2 2023-05-15T15:11:23+02:00 Human papillomavirus variants among Inuit women in northern Quebec, Canada Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard 2015-12-01T00:00:00Z https://doi.org/10.3402/ijch.v74.29482 https://doaj.org/article/eb40f831058b4b4db407162bf37e7ed2 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/29482/pdf_57 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.29482 https://doaj.org/article/eb40f831058b4b4db407162bf37e7ed2 International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-7 (2015) infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.3402/ijch.v74.29482 2022-12-31T03:41:29Z Background: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their nucleotide sequences. There is limited information on the distribution of intratypic variants in circumpolar areas. Objective: Our goal was to describe the HPV intratypic variants and associated baseline characteristics. Design: We collected cervical cell samples in 2002–2006 from 676 Inuit women between the ages of 15 and 69 years in Nunavik. DNA isolates from high-risk HPVs were sequenced to determine the intratypic variant. Results: There were 149 women that were positive for HPVs 16, 18, 31, 33, 35, 45, 52, 56 or 58 during follow-up. There were 5 different HPV16 variants, all of European lineage, among the 57 women positive for this type. There were 8 different variants of HPV18 present and all were of European lineage (n=21). The majority of samples of HPV31 (n=52) were of lineage B. The number of isolates and diversity of the other HPV types was low. Age was the only covariate associated with HPV16 variant category. Conclusions: These frequencies are similar to what was seen in another circumpolar region of Canada, although there appears to be less diversity as only European variants were detected. This study shows that most variants were clustered in one lineage for each HPV type. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik Directory of Open Access Journals: DOAJ Articles Arctic Nunavik Canada International Journal of Circumpolar Health 74 1 29482 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer Arctic medicine. Tropical medicine RC955-962 Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard Human papillomavirus variants among Inuit women in northern Quebec, Canada |
topic_facet |
infectious disease aboriginal health viral genetics epidemiology Inuit cervical cancer Arctic medicine. Tropical medicine RC955-962 |
description |
Background: Inuit communities in northern Quebec have high rates of human papillomavirus (HPV) infection, cervical cancer and cervical cancer–related mortality as compared to the Canadian population. HPV types can be further classified as intratypic variants based on the extent of homology in their nucleotide sequences. There is limited information on the distribution of intratypic variants in circumpolar areas. Objective: Our goal was to describe the HPV intratypic variants and associated baseline characteristics. Design: We collected cervical cell samples in 2002–2006 from 676 Inuit women between the ages of 15 and 69 years in Nunavik. DNA isolates from high-risk HPVs were sequenced to determine the intratypic variant. Results: There were 149 women that were positive for HPVs 16, 18, 31, 33, 35, 45, 52, 56 or 58 during follow-up. There were 5 different HPV16 variants, all of European lineage, among the 57 women positive for this type. There were 8 different variants of HPV18 present and all were of European lineage (n=21). The majority of samples of HPV31 (n=52) were of lineage B. The number of isolates and diversity of the other HPV types was low. Age was the only covariate associated with HPV16 variant category. Conclusions: These frequencies are similar to what was seen in another circumpolar region of Canada, although there appears to be less diversity as only European variants were detected. This study shows that most variants were clustered in one lineage for each HPV type. |
format |
Article in Journal/Newspaper |
author |
Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard |
author_facet |
Barbara Gauthier Francois Coutlée Eduardo L. Franco Paul Brassard |
author_sort |
Barbara Gauthier |
title |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_short |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_full |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_fullStr |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_full_unstemmed |
Human papillomavirus variants among Inuit women in northern Quebec, Canada |
title_sort |
human papillomavirus variants among inuit women in northern quebec, canada |
publisher |
Taylor & Francis Group |
publishDate |
2015 |
url |
https://doi.org/10.3402/ijch.v74.29482 https://doaj.org/article/eb40f831058b4b4db407162bf37e7ed2 |
geographic |
Arctic Nunavik Canada |
geographic_facet |
Arctic Nunavik Canada |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health inuit Nunavik |
op_source |
International Journal of Circumpolar Health, Vol 74, Iss 0, Pp 1-7 (2015) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/view/29482/pdf_57 https://doaj.org/toc/2242-3982 2242-3982 doi:10.3402/ijch.v74.29482 https://doaj.org/article/eb40f831058b4b4db407162bf37e7ed2 |
op_doi |
https://doi.org/10.3402/ijch.v74.29482 |
container_title |
International Journal of Circumpolar Health |
container_volume |
74 |
container_issue |
1 |
container_start_page |
29482 |
_version_ |
1766342241497907200 |