Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysac...
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MDPI AG
2018
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ftdoajarticles:oai:doaj.org/article:eaff93a032a6469da7a4b3f5927e2136 2023-05-15T16:29:43+02:00 Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats Olga N. Pozharitskaya Alexander N. Shikov Natalya M. Faustova Ekaterina D. Obluchinskaya Vera M. Kosman Heikki Vuorela Valery G. Makarov 2018-04-01T00:00:00Z https://doi.org/10.3390/md16040132 https://doaj.org/article/eaff93a032a6469da7a4b3f5927e2136 EN eng MDPI AG http://www.mdpi.com/1660-3397/16/4/132 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md16040132 https://doaj.org/article/eaff93a032a6469da7a4b3f5927e2136 Marine Drugs, Vol 16, Iss 4, p 132 (2018) anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.3390/md16040132 2022-12-30T23:38:10Z Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC0–t = 10.74 µg·h/g; Cmax = 1.23 µg/g after 5 h), spleen (AUC0–t = 6.89 µg·h/g; Cmax = 0.78 µg/g after 3 h), and liver (AUC0–t = 3.26 µg·h/g; Cmax = 0.53 µg/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. Article in Journal/Newspaper Greenland Directory of Open Access Journals: DOAJ Articles Greenland Pacific Marine Drugs 16 4 132 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen Biology (General) QH301-705.5 |
spellingShingle |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen Biology (General) QH301-705.5 Olga N. Pozharitskaya Alexander N. Shikov Natalya M. Faustova Ekaterina D. Obluchinskaya Vera M. Kosman Heikki Vuorela Valery G. Makarov Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
topic_facet |
anti-Xa activity Fucus vesiculosus fucoidan kidneys liver pharmacokinetic spleen Biology (General) QH301-705.5 |
description |
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus (F.) vesiculosus. The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration. Fucoidan was isolated from F. vesiculosus. The method of measuring anti-activated factor X (anti-Xa) activity by amidolytic assay was used to analyze the plasma and tissue concentrations of fucoidan. The tissue distribution of fucoidan after intragastric administration to the rats was characterized, and it exhibited considerable heterogeneity. Fucoidan preferentially accumulates in the kidneys (AUC0–t = 10.74 µg·h/g; Cmax = 1.23 µg/g after 5 h), spleen (AUC0–t = 6.89 µg·h/g; Cmax = 0.78 µg/g after 3 h), and liver (AUC0–t = 3.26 µg·h/g; Cmax = 0.53 µg/g after 2 h) and shows a relatively long absorption time and extended circulation in the blood, with a mean residence time (MRT) = 6.79 h. The outcome of this study provides additional scientific data for traditional use of fucoidan-containing plants and offers tangible support for the continued development of new effective pharmaceuticals using fucoidan. |
format |
Article in Journal/Newspaper |
author |
Olga N. Pozharitskaya Alexander N. Shikov Natalya M. Faustova Ekaterina D. Obluchinskaya Vera M. Kosman Heikki Vuorela Valery G. Makarov |
author_facet |
Olga N. Pozharitskaya Alexander N. Shikov Natalya M. Faustova Ekaterina D. Obluchinskaya Vera M. Kosman Heikki Vuorela Valery G. Makarov |
author_sort |
Olga N. Pozharitskaya |
title |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_short |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_fullStr |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_full_unstemmed |
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats |
title_sort |
pharmacokinetic and tissue distribution of fucoidan from fucus vesiculosus after oral administration to rats |
publisher |
MDPI AG |
publishDate |
2018 |
url |
https://doi.org/10.3390/md16040132 https://doaj.org/article/eaff93a032a6469da7a4b3f5927e2136 |
geographic |
Greenland Pacific |
geographic_facet |
Greenland Pacific |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
Marine Drugs, Vol 16, Iss 4, p 132 (2018) |
op_relation |
http://www.mdpi.com/1660-3397/16/4/132 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md16040132 https://doaj.org/article/eaff93a032a6469da7a4b3f5927e2136 |
op_doi |
https://doi.org/10.3390/md16040132 |
container_title |
Marine Drugs |
container_volume |
16 |
container_issue |
4 |
container_start_page |
132 |
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1766019428535762944 |