Lipid Profile of Children with Malaria by Plasmodium vivax

• Published in: Journal of Tropical Medicine
• Main Authors: Rosa Maria Dias, Jose Luiz Fernandes Vieira, Bianca da Conceição Cabral, Isameriliam Rosaulem Pereira da Silva, Laelia Maria Barra Feio Brasil, Eliete da Cunha Araújo, Marcieni Ataíde de Andrade
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1155/2016/9052612; https://doaj.org/article/ea68a0676a2145d39bd40cf3b314f687

Background. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed to P. vivax. Objective. To evaluate lipid abnormalities in children with P. vivax infection and to assess if parasite count or the history of malaria correlates with lipid levels at admission. Methods. A total of 75 children were included in the study, from which 43 were slide confirmed infection by P. vivax. Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Results. The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients. Conclusion. There are significant lipid abnormalities in children with low level of P. vivax infection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.