Gallbladder neuron count in cholelithiasis patients with and without Chagas disease Contagem de neurônios da vesícula biliar de pacientes chagásicos e não chagásicos portadores de colelitíase

Various investigators agree that the incidence of cholelithiasis is greater in patients with Chagas disease. The most plausible explanation for this is based on the parasympathetic denervation that occurs over the whole digestive tract due to Chagas disease. In order to analyze the occurrence of thi...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Eduardo Crema, Lara Beatriz Prata Ribeiro, Sheila Jorge Adad, Renata Margarida Ectchebehere, Aiodair Martins Júnior, Alex Augusto Silva
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2007
Subjects:
Doença de Chagas
Vesícula biliar
Colelitíase
Contagem neuronal
Chagas disease
Gallbladder
Cholelithiasis
Neuron count
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doi.org/10.1590/S0037-86822007000100003
https://doaj.org/article/ea5a64fc54cc4b0a9c4fd636daf1ef7d
Description
Summary:Various investigators agree that the incidence of cholelithiasis is greater in patients with Chagas disease. The most plausible explanation for this is based on the parasympathetic denervation that occurs over the whole digestive tract due to Chagas disease. In order to analyze the occurrence of this alteration, gallbladder neuron counts were performed on cholelithiasis patients with and without Chagas disease who were being treated at the Department of Digestive Surgery, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil. In the present study, a notable reduction in the number of neurons in the gallbladder wall was observed in Chagas patients, in comparison with non-Chagas subjects. Vários autores concordam que a incidência de colelitíase encontra-se elevada nos pacientes portadores de doença de Chagas. A explicação mais plausível para este fato baseia-se na desnervação parassimpática existente em todo o tubo digestivo na doença de Chagas. No intuito de analisar a ocorrência desta alteração, foi realizada contagem neuronal da vesícula biliar de pacientes chagásicos e não chagásicos, portadores de colelitíase, tratados na Disciplina de Cirurgia do Aparelho Digestivo, Universidade Federal do Triângulo Mineiro, Uberaba, Brasil. No presente estudo, observou-se uma redução expressiva do número de neurônios na parede da vesícula biliar dos pacientes chagásicos quando comparado com os não chagásicos.

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