Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries.
Background Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of society who are most at...
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ftdoajarticles:oai:doaj.org/article:ea499468232946dd901bf976eb8e1f47 2023-05-15T15:10:16+02:00 Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. Katie Hampson Sarah Cleaveland Deborah Briggs 2011-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000982 https://doaj.org/article/ea499468232946dd901bf976eb8e1f47 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408121/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000982 https://doaj.org/article/ea499468232946dd901bf976eb8e1f47 PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e982 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000982 2022-12-31T10:12:34Z Background Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of society who are most at risk and upon whom the largest burden of rabies falls. Increasing accessibility, reducing costs and preventing delays in delivery of PEP should therefore be prioritized. Methodology/principal findings We analyzed different PEP vaccination regimens and evaluated their relative costs and benefits to bite victims and healthcare providers. We found PEP vaccination to be an extremely cost-effective intervention (from $200 to less than $60/death averted). Switching from intramuscular (IM) administration of PEP to equally efficacious intradermal (ID) regimens was shown to result in significant savings in the volume of vaccine required to treat the same number of patients, which could mitigate vaccine shortages, and would dramatically reduce the costs of implementing PEP. We present financing mechanisms that would make PEP more affordable and accessible, could help subsidize the cost for those most in need, and could even support new and existing rabies control and prevention programs. Conclusions/significance We conclude that a universal switch to ID delivery would improve the affordability and accessibility of PEP for bite victims, leading to a likely reduction in human rabies deaths, as well as being economical for healthcare providers. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 3 e982 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Katie Hampson Sarah Cleaveland Deborah Briggs Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies. Unfortunately, life-saving rabies vaccines and biologicals are often neither accessible nor affordable, particularly to the poorest sectors of society who are most at risk and upon whom the largest burden of rabies falls. Increasing accessibility, reducing costs and preventing delays in delivery of PEP should therefore be prioritized. Methodology/principal findings We analyzed different PEP vaccination regimens and evaluated their relative costs and benefits to bite victims and healthcare providers. We found PEP vaccination to be an extremely cost-effective intervention (from $200 to less than $60/death averted). Switching from intramuscular (IM) administration of PEP to equally efficacious intradermal (ID) regimens was shown to result in significant savings in the volume of vaccine required to treat the same number of patients, which could mitigate vaccine shortages, and would dramatically reduce the costs of implementing PEP. We present financing mechanisms that would make PEP more affordable and accessible, could help subsidize the cost for those most in need, and could even support new and existing rabies control and prevention programs. Conclusions/significance We conclude that a universal switch to ID delivery would improve the affordability and accessibility of PEP for bite victims, leading to a likely reduction in human rabies deaths, as well as being economical for healthcare providers. |
format |
Article in Journal/Newspaper |
author |
Katie Hampson Sarah Cleaveland Deborah Briggs |
author_facet |
Katie Hampson Sarah Cleaveland Deborah Briggs |
author_sort |
Katie Hampson |
title |
Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
title_short |
Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
title_full |
Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
title_fullStr |
Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
title_full_unstemmed |
Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
title_sort |
evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000982 https://doaj.org/article/ea499468232946dd901bf976eb8e1f47 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e982 (2011) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408121/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000982 https://doaj.org/article/ea499468232946dd901bf976eb8e1f47 |
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https://doi.org/10.1371/journal.pntd.0000982 |
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PLoS Neglected Tropical Diseases |
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5 |
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3 |
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e982 |
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