Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Milena Polotto, Tiago Casella, Fernanda Modesto Tolentino, Mayra Mioto Mataruco, Naiady Konno Madela Porto, Mirella Fontana Batista Binhardi, Mara Corrêa Lelles Nogueira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019
• Subjects: Acinetobacter baumannii; Carbapenemases; Aminoglycoside modifying enzymes; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0094-2019; https://doaj.org/article/ea3c339f8de549e4b5bac296a5bc9230

Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla OXA-51-like, the association ISAba1- bla OXA-23-like, and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.