Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução
From February, 1981 to May, 2001, 63 children under 15 y old (ages 2 - 15 y, median = 8 y, mean ± 1 SD = 8 ± 3 y) presenting 70 episodes of Paracoccidioidomycosis were admitted. The main clinical manifestations and laboratory features observed upon admission were: lymph node enlargement (87.1%), fev...
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ftdoajarticles:oai:doaj.org/article:ea2e4b7d59844fb69199810c9c374474 2023-05-15T15:14:52+02:00 Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução Ricardo Mendes Pereira Fábio Bucaretchi Eliana de Melo Barison Gabriel Hessel Antonia Teresinha Tresoldi 2004-06-01T00:00:00Z https://doi.org/10.1590/S0036-46652004000300002 https://doaj.org/article/ea2e4b7d59844fb69199810c9c374474 EN PT eng por Universidade de São Paulo http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000300002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652004000300002 0036-4665 1678-9946 https://doaj.org/article/ea2e4b7d59844fb69199810c9c374474 Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 3, Pp 127-131 (2004) Paracoccidioidomycosis Paracoccidioides brasiliensis Children Eosinophilia Hypergammaglobulinemia Sulfametoxazole-trimethoprin Arctic medicine. Tropical medicine RC955-962 article 2004 ftdoajarticles https://doi.org/10.1590/S0036-46652004000300002 2023-01-08T01:33:16Z From February, 1981 to May, 2001, 63 children under 15 y old (ages 2 - 15 y, median = 8 y, mean ± 1 SD = 8 ± 3 y) presenting 70 episodes of Paracoccidioidomycosis were admitted. The main clinical manifestations and laboratory features observed upon admission were: lymph node enlargement (87.1%), fever (75.7%), weakness (48.6%), pallor (41.4%), hepatomegaly (40%), splenomegaly (35.7%), anemia (90%), hypergammaglobulinemia (88.5%), eosinophilia (75.5%) and hypoalbuminemia (72.5%). Moderate to severe malnutrition was detected in 35.7% of the episodes (Gomez's criterion). Radiographic and technetium studies showed bone lesions in 20 of the episodes, most of them being multiple lytic lesions, involving both long (70%) and plain bones (30%). First line treatment consisted of an association of sulfametoxazole-trimethoprin, which was used, exclusively, in 50 episodes. Follow-up of hemoglobin levels, number of eosinophils in the peripheral blood, albumin and gammaglobulin serum levels revealed significant sequential improvement one and six months after hospital admission, being quite useful to evaluate treatment effectiveness. Six patients died (9.3%) and four developed sequelae (6.3%) . In conclusion, the juvenile and disseminated forms can be observed in about 70% of the episodes of PCM occurring in children younger than 15 y old, most of them presenting with a febrile lymphoproliferative syndrome associated to anemia, eosinophilia and hypergammaglobulinemia. Foram analisados 70 episódios de Paracoccidioidomicose em 63 crianças com menos de 15 anos de idade (variação de 2 a 15 anos, mediana = 8 anos, média ± 1 DP = 8 ± 3 anos), no período de fevereiro de 1981 a maio de 2001. As principais manifestações clínicas e alterações laboratoriais à admissão foram: linfonodomegalia (87,1%), febre (75,7%), fraqueza (48,6%), palidez (41,4%), hepatomegalia (40,4%), esplenomegalia (35,7%), anemia (90%), hipergamaglobulinemia (88,5%), eosinofilia (75,5%) e hipoalbuminemia 72,5%. À admissão, 35,7% das crianças apresentavam desnutrição ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 46 3 127 131 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Portuguese |
topic |
Paracoccidioidomycosis Paracoccidioides brasiliensis Children Eosinophilia Hypergammaglobulinemia Sulfametoxazole-trimethoprin Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Paracoccidioidomycosis Paracoccidioides brasiliensis Children Eosinophilia Hypergammaglobulinemia Sulfametoxazole-trimethoprin Arctic medicine. Tropical medicine RC955-962 Ricardo Mendes Pereira Fábio Bucaretchi Eliana de Melo Barison Gabriel Hessel Antonia Teresinha Tresoldi Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
topic_facet |
Paracoccidioidomycosis Paracoccidioides brasiliensis Children Eosinophilia Hypergammaglobulinemia Sulfametoxazole-trimethoprin Arctic medicine. Tropical medicine RC955-962 |
description |
From February, 1981 to May, 2001, 63 children under 15 y old (ages 2 - 15 y, median = 8 y, mean ± 1 SD = 8 ± 3 y) presenting 70 episodes of Paracoccidioidomycosis were admitted. The main clinical manifestations and laboratory features observed upon admission were: lymph node enlargement (87.1%), fever (75.7%), weakness (48.6%), pallor (41.4%), hepatomegaly (40%), splenomegaly (35.7%), anemia (90%), hypergammaglobulinemia (88.5%), eosinophilia (75.5%) and hypoalbuminemia (72.5%). Moderate to severe malnutrition was detected in 35.7% of the episodes (Gomez's criterion). Radiographic and technetium studies showed bone lesions in 20 of the episodes, most of them being multiple lytic lesions, involving both long (70%) and plain bones (30%). First line treatment consisted of an association of sulfametoxazole-trimethoprin, which was used, exclusively, in 50 episodes. Follow-up of hemoglobin levels, number of eosinophils in the peripheral blood, albumin and gammaglobulin serum levels revealed significant sequential improvement one and six months after hospital admission, being quite useful to evaluate treatment effectiveness. Six patients died (9.3%) and four developed sequelae (6.3%) . In conclusion, the juvenile and disseminated forms can be observed in about 70% of the episodes of PCM occurring in children younger than 15 y old, most of them presenting with a febrile lymphoproliferative syndrome associated to anemia, eosinophilia and hypergammaglobulinemia. Foram analisados 70 episódios de Paracoccidioidomicose em 63 crianças com menos de 15 anos de idade (variação de 2 a 15 anos, mediana = 8 anos, média ± 1 DP = 8 ± 3 anos), no período de fevereiro de 1981 a maio de 2001. As principais manifestações clínicas e alterações laboratoriais à admissão foram: linfonodomegalia (87,1%), febre (75,7%), fraqueza (48,6%), palidez (41,4%), hepatomegalia (40,4%), esplenomegalia (35,7%), anemia (90%), hipergamaglobulinemia (88,5%), eosinofilia (75,5%) e hipoalbuminemia 72,5%. À admissão, 35,7% das crianças apresentavam desnutrição ... |
format |
Article in Journal/Newspaper |
author |
Ricardo Mendes Pereira Fábio Bucaretchi Eliana de Melo Barison Gabriel Hessel Antonia Teresinha Tresoldi |
author_facet |
Ricardo Mendes Pereira Fábio Bucaretchi Eliana de Melo Barison Gabriel Hessel Antonia Teresinha Tresoldi |
author_sort |
Ricardo Mendes Pereira |
title |
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
title_short |
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
title_full |
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
title_fullStr |
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
title_full_unstemmed |
Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome Paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
title_sort |
paracoccidioidomycosis in children: clinical presentation, follow-up and outcome paracoccidioidomicose em crianças: apresentação clínica, seguimento e evolução |
publisher |
Universidade de São Paulo |
publishDate |
2004 |
url |
https://doi.org/10.1590/S0036-46652004000300002 https://doaj.org/article/ea2e4b7d59844fb69199810c9c374474 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 3, Pp 127-131 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000300002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652004000300002 0036-4665 1678-9946 https://doaj.org/article/ea2e4b7d59844fb69199810c9c374474 |
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https://doi.org/10.1590/S0036-46652004000300002 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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