Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort
Abstract Background Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. Methods We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had...
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ftdoajarticles:oai:doaj.org/article:e9d7e4ac508b4751ba1af6eb38063ac8 2023-05-15T17:44:29+02:00 Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort Renée T. Fortner Eglé Tolockiene Helena Schock Husam Oda Hans-Åke Lakso Göran Hallmans Rudolf Kaaks Paolo Toniolo Anne Zeleniuch-Jacquotte Kjell Grankvist Eva Lundin 2017-07-01T00:00:00Z https://doi.org/10.1186/s13058-017-0876-8 https://doaj.org/article/e9d7e4ac508b4751ba1af6eb38063ac8 EN eng BMC http://link.springer.com/article/10.1186/s13058-017-0876-8 https://doaj.org/toc/1465-542X doi:10.1186/s13058-017-0876-8 1465-542X https://doaj.org/article/e9d7e4ac508b4751ba1af6eb38063ac8 Breast Cancer Research, Vol 19, Iss 1, Pp 1-8 (2017) Endogenous hormones Early pregnancy Breast cancer Sex steroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2017 ftdoajarticles https://doi.org/10.1186/s13058-017-0876-8 2022-12-31T05:44:44Z Abstract Background Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. Methods We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression. Results Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease. Conclusions Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Breast Cancer Research 19 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Endogenous hormones Early pregnancy Breast cancer Sex steroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
Endogenous hormones Early pregnancy Breast cancer Sex steroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Renée T. Fortner Eglé Tolockiene Helena Schock Husam Oda Hans-Åke Lakso Göran Hallmans Rudolf Kaaks Paolo Toniolo Anne Zeleniuch-Jacquotte Kjell Grankvist Eva Lundin Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
topic_facet |
Endogenous hormones Early pregnancy Breast cancer Sex steroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Abstract Background Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. Methods We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression. Results Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease. Conclusions Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease. |
format |
Article in Journal/Newspaper |
author |
Renée T. Fortner Eglé Tolockiene Helena Schock Husam Oda Hans-Åke Lakso Göran Hallmans Rudolf Kaaks Paolo Toniolo Anne Zeleniuch-Jacquotte Kjell Grankvist Eva Lundin |
author_facet |
Renée T. Fortner Eglé Tolockiene Helena Schock Husam Oda Hans-Åke Lakso Göran Hallmans Rudolf Kaaks Paolo Toniolo Anne Zeleniuch-Jacquotte Kjell Grankvist Eva Lundin |
author_sort |
Renée T. Fortner |
title |
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
title_short |
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
title_full |
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
title_fullStr |
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
title_full_unstemmed |
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the Northern Sweden Maternity Cohort |
title_sort |
early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case–control study in the northern sweden maternity cohort |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s13058-017-0876-8 https://doaj.org/article/e9d7e4ac508b4751ba1af6eb38063ac8 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Breast Cancer Research, Vol 19, Iss 1, Pp 1-8 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s13058-017-0876-8 https://doaj.org/toc/1465-542X doi:10.1186/s13058-017-0876-8 1465-542X https://doaj.org/article/e9d7e4ac508b4751ba1af6eb38063ac8 |
op_doi |
https://doi.org/10.1186/s13058-017-0876-8 |
container_title |
Breast Cancer Research |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766146717321789440 |