Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia
Objective: To compare the reporting pattern of hearing loss and tinnitus across different vaccines brands used in Malaysia (BNT162b2, CoronaVac, ChAdOx1, Ad5.CoV2-S and BBIBP-CorV). Methods: This retrospective study included all reports of hearing loss and tinnitus occurring after COVID-19 vaccinati...
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ftdoajarticles:oai:doaj.org/article:e9c6be04eed741fb819c401c77044c35 2023-11-12T04:13:28+01:00 Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia Sing Chet Lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.380718 https://doaj.org/article/e9c6be04eed741fb819c401c77044c35 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=7;spage=289;epage=295;aulast=Lee https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.380718 https://doaj.org/article/e9c6be04eed741fb819c401c77044c35 Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 7, Pp 289-295 (2023) covid-19 vaccines hearing loss tinnitus adverse events following immunization Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.380718 2023-10-29T00:38:43Z Objective: To compare the reporting pattern of hearing loss and tinnitus across different vaccines brands used in Malaysia (BNT162b2, CoronaVac, ChAdOx1, Ad5.CoV2-S and BBIBP-CorV). Methods: This retrospective study included all reports of hearing loss and tinnitus occurring after COVID-19 vaccination that were received in the national pharmacovigilance database, QUEST, from February 24, 2021 through July 31, 2022. Reports given causality consistent or indeterminate were included. Results: There were 21 cases of hearing loss, with overall reporting rate of 0.29 cases per million doses. The rate was similar across BNT162b2, CoronaVac and ChAdOx1. For tinnitus, 35 cases were reported, with the overall reporting rate of 0.49 cases per million doses, and the highest rate was reported for ChAdOx1. For both events, most cases aged 30 to 49 years. No gender disparity was observed. Both events were mainly reported to have occurred after the primary doses, with a median time-to-onset of two days. There were no statistically significant differences in the reporting patterns for both events across BNT162b2, CoronaVac and ChAdOx1 by age group, gender, race, and dose number. Conclusions: Despite the low reporting rates and insufficient evidence to confirm its relationship, hearing loss and tinnitus following vaccinations should not be ignored due to its disabling potential and impact on one’s quality of life. Continual reporting is encouraged for better signal characterization in the future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Medicine 16 7 289 295 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
covid-19 vaccines hearing loss tinnitus adverse events following immunization Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
covid-19 vaccines hearing loss tinnitus adverse events following immunization Arctic medicine. Tropical medicine RC955-962 Sing Chet Lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
topic_facet |
covid-19 vaccines hearing loss tinnitus adverse events following immunization Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To compare the reporting pattern of hearing loss and tinnitus across different vaccines brands used in Malaysia (BNT162b2, CoronaVac, ChAdOx1, Ad5.CoV2-S and BBIBP-CorV). Methods: This retrospective study included all reports of hearing loss and tinnitus occurring after COVID-19 vaccination that were received in the national pharmacovigilance database, QUEST, from February 24, 2021 through July 31, 2022. Reports given causality consistent or indeterminate were included. Results: There were 21 cases of hearing loss, with overall reporting rate of 0.29 cases per million doses. The rate was similar across BNT162b2, CoronaVac and ChAdOx1. For tinnitus, 35 cases were reported, with the overall reporting rate of 0.49 cases per million doses, and the highest rate was reported for ChAdOx1. For both events, most cases aged 30 to 49 years. No gender disparity was observed. Both events were mainly reported to have occurred after the primary doses, with a median time-to-onset of two days. There were no statistically significant differences in the reporting patterns for both events across BNT162b2, CoronaVac and ChAdOx1 by age group, gender, race, and dose number. Conclusions: Despite the low reporting rates and insufficient evidence to confirm its relationship, hearing loss and tinnitus following vaccinations should not be ignored due to its disabling potential and impact on one’s quality of life. Continual reporting is encouraged for better signal characterization in the future. |
format |
Article in Journal/Newspaper |
author |
Sing Chet Lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli |
author_facet |
Sing Chet Lee Wee Kee Wo Hee Sheong Yeoh Sim Mei Choo Azuana Ramli |
author_sort |
Sing Chet Lee |
title |
Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
title_short |
Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
title_full |
Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
title_fullStr |
Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
title_full_unstemmed |
Hearing loss and tinnitus associated with COVID-19 vaccines: An analysis from the national pharmacovigilance database in Malaysia |
title_sort |
hearing loss and tinnitus associated with covid-19 vaccines: an analysis from the national pharmacovigilance database in malaysia |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.380718 https://doaj.org/article/e9c6be04eed741fb819c401c77044c35 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 7, Pp 289-295 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=7;spage=289;epage=295;aulast=Lee https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.380718 https://doaj.org/article/e9c6be04eed741fb819c401c77044c35 |
op_doi |
https://doi.org/10.4103/1995-7645.380718 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
7 |
container_start_page |
289 |
op_container_end_page |
295 |
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1782331456681410560 |