Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study
Background. Limited information exists on the etiologies, clinical characteristics, and outcomes of meningitis among HIV-infected patients in Africa. We conducted a study to determine the etiology, clinical characteristics, and outcomes of meningitis among HIV-infected adults. Methods. A prospective...
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ftdoajarticles:oai:doaj.org/article:e9bd5272331b4958b78e0a6be95788c8 2023-05-15T15:09:07+02:00 Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study Matobogolo M. Boaz Samuel Kalluvya Jennifer A. Downs Bonaventura C. T. Mpondo Stephen E. Mshana 2016-01-01T00:00:00Z https://doi.org/10.1155/2016/6573672 https://doaj.org/article/e9bd5272331b4958b78e0a6be95788c8 EN eng Hindawi Limited http://dx.doi.org/10.1155/2016/6573672 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/6573672 https://doaj.org/article/e9bd5272331b4958b78e0a6be95788c8 Journal of Tropical Medicine, Vol 2016 (2016) Arctic medicine. Tropical medicine RC955-962 article 2016 ftdoajarticles https://doi.org/10.1155/2016/6573672 2022-12-31T08:30:37Z Background. Limited information exists on the etiologies, clinical characteristics, and outcomes of meningitis among HIV-infected patients in Africa. We conducted a study to determine the etiology, clinical characteristics, and outcomes of meningitis among HIV-infected adults. Methods. A prospective cross-sectional hospital based study was conducted among HIV-infected patients aged ≥18 years admitted to the medical wards with symptoms and signs of meningitis. Sociodemographic and clinical information were collected using a standardized data collection tool. Lumbar puncture was performed to all patients; cerebrospinal fluid samples were sent for analysis. Results. Among 60 HIV-infected adults clinically diagnosed to have meningitis, 55 had CSF profiles consistent with meningitis. Of these, 14 (25.5%) had a laboratory-confirmed etiology while 41 (74.5%) had no isolate identified. Cryptococcus neoformans was the commonest cause of meningitis occurring in 11 (18.3%) of patients followed by Mycobacterium tuberculosis (6.7%). The in-hospital mortality was 20/55 (36.4%). Independent predictors of mortality were low baseline CD4 count and turbid CSF appearance. Conclusion. Cryptococcal meningitis is the most prevalent laboratory-confirmed etiological agent among adult HIV-infected patients with suspected meningitis admitted to medical wards in Western Tanzania. Mortality rate in this population remains unacceptably high. Improving diagnostic capacity and early treatment may help to decrease the mortality rate. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2016 1 7 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Matobogolo M. Boaz Samuel Kalluvya Jennifer A. Downs Bonaventura C. T. Mpondo Stephen E. Mshana Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Limited information exists on the etiologies, clinical characteristics, and outcomes of meningitis among HIV-infected patients in Africa. We conducted a study to determine the etiology, clinical characteristics, and outcomes of meningitis among HIV-infected adults. Methods. A prospective cross-sectional hospital based study was conducted among HIV-infected patients aged ≥18 years admitted to the medical wards with symptoms and signs of meningitis. Sociodemographic and clinical information were collected using a standardized data collection tool. Lumbar puncture was performed to all patients; cerebrospinal fluid samples were sent for analysis. Results. Among 60 HIV-infected adults clinically diagnosed to have meningitis, 55 had CSF profiles consistent with meningitis. Of these, 14 (25.5%) had a laboratory-confirmed etiology while 41 (74.5%) had no isolate identified. Cryptococcus neoformans was the commonest cause of meningitis occurring in 11 (18.3%) of patients followed by Mycobacterium tuberculosis (6.7%). The in-hospital mortality was 20/55 (36.4%). Independent predictors of mortality were low baseline CD4 count and turbid CSF appearance. Conclusion. Cryptococcal meningitis is the most prevalent laboratory-confirmed etiological agent among adult HIV-infected patients with suspected meningitis admitted to medical wards in Western Tanzania. Mortality rate in this population remains unacceptably high. Improving diagnostic capacity and early treatment may help to decrease the mortality rate. |
format |
Article in Journal/Newspaper |
author |
Matobogolo M. Boaz Samuel Kalluvya Jennifer A. Downs Bonaventura C. T. Mpondo Stephen E. Mshana |
author_facet |
Matobogolo M. Boaz Samuel Kalluvya Jennifer A. Downs Bonaventura C. T. Mpondo Stephen E. Mshana |
author_sort |
Matobogolo M. Boaz |
title |
Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
title_short |
Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
title_full |
Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
title_fullStr |
Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
title_full_unstemmed |
Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study |
title_sort |
pattern, clinical characteristics, and outcome of meningitis among hiv-infected adults admitted in a tertiary hospital in north western tanzania: a cross-sectional study |
publisher |
Hindawi Limited |
publishDate |
2016 |
url |
https://doi.org/10.1155/2016/6573672 https://doaj.org/article/e9bd5272331b4958b78e0a6be95788c8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2016 (2016) |
op_relation |
http://dx.doi.org/10.1155/2016/6573672 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2016/6573672 https://doaj.org/article/e9bd5272331b4958b78e0a6be95788c8 |
op_doi |
https://doi.org/10.1155/2016/6573672 |
container_title |
Journal of Tropical Medicine |
container_volume |
2016 |
container_start_page |
1 |
op_container_end_page |
7 |
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1766340347516944384 |