Stroke in Chagas disease: from pathophysiology to clinical practice
ABSTRACT Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern. The disease affects approximately 6 million people, of whom 20-40% will develop cardiomyopathy over the years after the init...
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ftdoajarticles:oai:doaj.org/article:e9afed3baabb4ec5b28137316f9bfe92 2023-05-15T15:08:39+02:00 Stroke in Chagas disease: from pathophysiology to clinical practice Thaís Aparecida Reis Lage Julia Teixeira Tupinambás Lucas Bretas de Pádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes 2022-06-01T00:00:00Z https://doi.org/10.1590/0037-8682-0575-2021 https://doaj.org/article/e9afed3baabb4ec5b28137316f9bfe92 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100253&lng=en&tlng=en http://www.scielo.br/pdf/rsbmt/v55/1678-9849-rsbmt-55-e0575-2021.pdf https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0575-2021 https://doaj.org/article/e9afed3baabb4ec5b28137316f9bfe92 Revista da Sociedade Brasileira de Medicina Tropical, Vol 55 (2022) Stroke Chagas disease Pathophysiology Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.1590/0037-8682-0575-2021 2022-12-31T02:46:18Z ABSTRACT Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern. The disease affects approximately 6 million people, of whom 20-40% will develop cardiomyopathy over the years after the initial Trypanosoma cruzi infection. Chagas cardiomyopathy is the most serious and frequent manifestation of Chagas disease. Clinical manifestations vary widely according to the severity of myocardial dysfunction, ranging from asymptomatic to severe forms, including dilated cardiomyopathy with heart failure, arrhythmias, thromboembolism events, and sudden death. Chagas disease is a risk factor for stroke regardless of the severity of cardiomyopathy, which is a leading cause of chronic disability. Classically, stroke etiology in patients with Chagas disease is thought to be cardioembolic and related to apical aneurysm, mural thrombus, and atrial arrhythmias. Although most strokes are thromboembolic, other etiologies have been observed. Small vessel disease, atherosclerosis, and cryptogenic diseases have been reported in patients with Chagas disease and stroke. The potential mechanisms involved in non-embolic strokes include the presence of associated risk factors, pro-inflammatory and prothrombotic disease states, and endothelial dysfunction. However, the contribution of each mechanism to stroke in Chagas disease remains unclear. The review aims to provide an overview of stroke in Chagas disease, highlighting the main pathophysiological mechanisms, clinical presentation, approaches for prevention, and unanswered questions regarding treatment strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 55 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Stroke Chagas disease Pathophysiology Arctic medicine. Tropical medicine RC955-962 |
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Stroke Chagas disease Pathophysiology Arctic medicine. Tropical medicine RC955-962 Thaís Aparecida Reis Lage Julia Teixeira Tupinambás Lucas Bretas de Pádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes Stroke in Chagas disease: from pathophysiology to clinical practice |
topic_facet |
Stroke Chagas disease Pathophysiology Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT Despite substantial progress toward its control, Chagas disease continues to be a major public health problem in Latin America and has become a global health concern. The disease affects approximately 6 million people, of whom 20-40% will develop cardiomyopathy over the years after the initial Trypanosoma cruzi infection. Chagas cardiomyopathy is the most serious and frequent manifestation of Chagas disease. Clinical manifestations vary widely according to the severity of myocardial dysfunction, ranging from asymptomatic to severe forms, including dilated cardiomyopathy with heart failure, arrhythmias, thromboembolism events, and sudden death. Chagas disease is a risk factor for stroke regardless of the severity of cardiomyopathy, which is a leading cause of chronic disability. Classically, stroke etiology in patients with Chagas disease is thought to be cardioembolic and related to apical aneurysm, mural thrombus, and atrial arrhythmias. Although most strokes are thromboembolic, other etiologies have been observed. Small vessel disease, atherosclerosis, and cryptogenic diseases have been reported in patients with Chagas disease and stroke. The potential mechanisms involved in non-embolic strokes include the presence of associated risk factors, pro-inflammatory and prothrombotic disease states, and endothelial dysfunction. However, the contribution of each mechanism to stroke in Chagas disease remains unclear. The review aims to provide an overview of stroke in Chagas disease, highlighting the main pathophysiological mechanisms, clinical presentation, approaches for prevention, and unanswered questions regarding treatment strategies. |
format |
Article in Journal/Newspaper |
author |
Thaís Aparecida Reis Lage Julia Teixeira Tupinambás Lucas Bretas de Pádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes |
author_facet |
Thaís Aparecida Reis Lage Julia Teixeira Tupinambás Lucas Bretas de Pádua Matheus de Oliveira Ferreira Amanda Cambraia Ferreira Antonio Lucio Teixeira Maria Carmo Pereira Nunes |
author_sort |
Thaís Aparecida Reis Lage |
title |
Stroke in Chagas disease: from pathophysiology to clinical practice |
title_short |
Stroke in Chagas disease: from pathophysiology to clinical practice |
title_full |
Stroke in Chagas disease: from pathophysiology to clinical practice |
title_fullStr |
Stroke in Chagas disease: from pathophysiology to clinical practice |
title_full_unstemmed |
Stroke in Chagas disease: from pathophysiology to clinical practice |
title_sort |
stroke in chagas disease: from pathophysiology to clinical practice |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2022 |
url |
https://doi.org/10.1590/0037-8682-0575-2021 https://doaj.org/article/e9afed3baabb4ec5b28137316f9bfe92 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 55 (2022) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100253&lng=en&tlng=en http://www.scielo.br/pdf/rsbmt/v55/1678-9849-rsbmt-55-e0575-2021.pdf https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0575-2021 https://doaj.org/article/e9afed3baabb4ec5b28137316f9bfe92 |
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https://doi.org/10.1590/0037-8682-0575-2021 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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