Outcome of life-threatening malaria in African children requiring endotracheal intubation
Abstract Background Little is known about children undergoing critical care for malaria. The purpose of this survey was to evaluate the outcome in African children requiring endotracheal intubation for life-threatening malaria. Methods All children with a primary diagnosis of severe malaria (2000 WH...
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ftdoajarticles:oai:doaj.org/article:e99fcac565a847ae8c0d6862592dace7 2023-05-15T15:14:10+02:00 Outcome of life-threatening malaria in African children requiring endotracheal intubation Ka Amadou S Rogier Christophe Gérardin Patrick Jouvencel Philippe Diatta Bakary Imbert Patrick 2007-04-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-51 https://doaj.org/article/e99fcac565a847ae8c0d6862592dace7 EN eng BMC http://www.malariajournal.com/content/6/1/51 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-51 1475-2875 https://doaj.org/article/e99fcac565a847ae8c0d6862592dace7 Malaria Journal, Vol 6, Iss 1, p 51 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-51 2022-12-31T09:09:37Z Abstract Background Little is known about children undergoing critical care for malaria. The purpose of this survey was to evaluate the outcome in African children requiring endotracheal intubation for life-threatening malaria. Methods All children with a primary diagnosis of severe malaria (2000 WHO definition) requiring endotracheal intubation, hospitalised over a five-year period, within a tertiary-care hospital in Dakar, Senegal, were enrolled in a retrospective cohort study. Results 83 consecutive patients were included (median PRISM h 24 score: 14; IQR: 10–19, multiple organ dysfunctions: 91.5%). The median duration of ventilation was 36 hrs (IQR: 4–72). Indications for intubation were deep coma (Glasgow score ≤7, n = 16), overt cortical or diencephalic injury, i.e, status epilepticus/decorticate posturing (n = 20), severe brainstem involvement, i.e., decerebrate posturing/opisthotonus (n = 15), shock (n = 15), cardiac arrest (n = 13) or acute lung injury (ALI) (PaO 2 /FiO 2 <300 Torr, n = 4). Death occurred in 50 cases (case fatality rate (CFR), 60%) and was associated with multiple organ dysfunctions (median PELOD h24 scores: 12.5 among non-survivors versus 11 among survivors, p = 0.02). Median PRISM h24 score was significantly lower when testing deep coma against other indications (10 vs 15, p < 0.001), ditto for PELOD h24 score (2.5 vs 13, p = 0.02). Multivariate analysis identified deep coma as having a better outcome than other indications (CFR, 12.5% vs 40.0 to 93.3%, p < 0.0001). Decerebrate posturing/opisthotonus (CFR 73.3%, adjusted relative risk (aRR) 10.7, 95% CI 2.3–49.5) were associated with a far worse prognosis than status epilepticus/decorticate posturing (CFR 40.0%, aRR 5.7, 95% CI 1.2–27.1). Thrombocytopaenia (platelet counts <100,000/mm 3 ) was associated with death (aRR 2.6, 95% CI 1.2–5.8) and second-line anticonvulsant use (clonazepam or thiopental) with survival (aRR 0.4, 95% CI 0.2–0.9). Complications, mostly nosocomial infections (n = 20), ALI/ARDS (n = 9) or ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 51 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ka Amadou S Rogier Christophe Gérardin Patrick Jouvencel Philippe Diatta Bakary Imbert Patrick Outcome of life-threatening malaria in African children requiring endotracheal intubation |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Little is known about children undergoing critical care for malaria. The purpose of this survey was to evaluate the outcome in African children requiring endotracheal intubation for life-threatening malaria. Methods All children with a primary diagnosis of severe malaria (2000 WHO definition) requiring endotracheal intubation, hospitalised over a five-year period, within a tertiary-care hospital in Dakar, Senegal, were enrolled in a retrospective cohort study. Results 83 consecutive patients were included (median PRISM h 24 score: 14; IQR: 10–19, multiple organ dysfunctions: 91.5%). The median duration of ventilation was 36 hrs (IQR: 4–72). Indications for intubation were deep coma (Glasgow score ≤7, n = 16), overt cortical or diencephalic injury, i.e, status epilepticus/decorticate posturing (n = 20), severe brainstem involvement, i.e., decerebrate posturing/opisthotonus (n = 15), shock (n = 15), cardiac arrest (n = 13) or acute lung injury (ALI) (PaO 2 /FiO 2 <300 Torr, n = 4). Death occurred in 50 cases (case fatality rate (CFR), 60%) and was associated with multiple organ dysfunctions (median PELOD h24 scores: 12.5 among non-survivors versus 11 among survivors, p = 0.02). Median PRISM h24 score was significantly lower when testing deep coma against other indications (10 vs 15, p < 0.001), ditto for PELOD h24 score (2.5 vs 13, p = 0.02). Multivariate analysis identified deep coma as having a better outcome than other indications (CFR, 12.5% vs 40.0 to 93.3%, p < 0.0001). Decerebrate posturing/opisthotonus (CFR 73.3%, adjusted relative risk (aRR) 10.7, 95% CI 2.3–49.5) were associated with a far worse prognosis than status epilepticus/decorticate posturing (CFR 40.0%, aRR 5.7, 95% CI 1.2–27.1). Thrombocytopaenia (platelet counts <100,000/mm 3 ) was associated with death (aRR 2.6, 95% CI 1.2–5.8) and second-line anticonvulsant use (clonazepam or thiopental) with survival (aRR 0.4, 95% CI 0.2–0.9). Complications, mostly nosocomial infections (n = 20), ALI/ARDS (n = 9) or ... |
format |
Article in Journal/Newspaper |
author |
Ka Amadou S Rogier Christophe Gérardin Patrick Jouvencel Philippe Diatta Bakary Imbert Patrick |
author_facet |
Ka Amadou S Rogier Christophe Gérardin Patrick Jouvencel Philippe Diatta Bakary Imbert Patrick |
author_sort |
Ka Amadou S |
title |
Outcome of life-threatening malaria in African children requiring endotracheal intubation |
title_short |
Outcome of life-threatening malaria in African children requiring endotracheal intubation |
title_full |
Outcome of life-threatening malaria in African children requiring endotracheal intubation |
title_fullStr |
Outcome of life-threatening malaria in African children requiring endotracheal intubation |
title_full_unstemmed |
Outcome of life-threatening malaria in African children requiring endotracheal intubation |
title_sort |
outcome of life-threatening malaria in african children requiring endotracheal intubation |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-51 https://doaj.org/article/e99fcac565a847ae8c0d6862592dace7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 51 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/51 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-51 1475-2875 https://doaj.org/article/e99fcac565a847ae8c0d6862592dace7 |
op_doi |
https://doi.org/10.1186/1475-2875-6-51 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
container_start_page |
51 |
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1766344660722122752 |